Medicine and Health Sciences Commons^™

Csrp1 Expression Is Associated With A Mesenchymal, Stroma-Rich Tumor Profile And Poor Prognosis In Colon Cancer, Seçi̇l Demi̇rkol Canli

Turkish Journal of Medical Sciences

Background/aim: Cysteine and glycine-rich protein 1 (CSRP1) is involved in the cysteine-rich protein family and is a marker of smooth muscle lineages. In colon cancer, the expression of this gene is associated with poor prognosis. In this study, the aim was to reevaluate its prognostic relationship in independent cohorts and explore potential underlying biological processes that are linked to aggressive behavior in tumors with high CSRP1 expression, such as epithelial-to-mesenchymal transition (EMT), stromal fractions in the tumor microenvironment, and consensus molecular subtypes (CMSs). Materials and methods: RNA sequencing (RNAseq)-, microarray-, and single-cell RNAseq (scRNAseq)-based transcriptomic data were obtained from public …

Management And Prognosis Of Patients With Cancer Of Unknown Primary: 20 Years Of Experience, Murat Bardakçi, Efnan Algin, Büşra Dügeroğlu, Öznur Bal, Fahri̇ye Tuğba Köş, Doğan Uncu

Turkish Journal of Medical Sciences

Background/aim: Cancer of unknown primary (CUP) is a difficult clinical entity to manage. The aim of the study was to investigate the sociodemographic and pathological characteristics, treatment options, and factors affecting overall survival (OS) in CUP patients whose primary tumor was not detected during follow-up. Materials and methods: A total of 243 CUP patients whose primary tumors could not be detected during follow-up were included in the study. Their demographic characteristics, survival outcomes, and prognostic factors were investigated. Results: Of the 243 patients included in this study, 61.7% were male and 38.3% were female, and the median age was 61 …

Comprehensive Comparison Of Clinicoradiological, Laboratory, And Prognostic Factors Of Community-Acquired Pneumonia In Diabetic And Nondiabetic Hospitalized Patients, Seyyed Hamid Hashemi, Fatemeh Saki, Shiva Borzouei, Rashed Bawand, Alireza Soltanian

Turkish Journal of Medical Sciences

Background/aim: Community-acquired pneumonia (CAP) is one of the leading infectious causes of mortality, and diabetes mellitus is a globally prevalent disease. Consequently, the cooccurrence of these two disorders can be common and create challenging medical conditions. Therefore, it was aimed to compare the various aspects of CAP in diabetic and nondiabetic patients, in order to have a comprehensive and comparative picture of the differences. Materials and methods: In this cross-sectional study, CAP patients with and without diabetes were assessed for clinicoradiological signs, laboratory features, disease severity, and pneumonia outcomes. Results: Analyzed herein were 172 CAP patients (77 had diabetes and …

Tripartite Motif Protein 6 Promotes Hepatocellular Carcinoma Progression Via Multiple Pathways, Yifeng Zhang, Lin Yuan, Shanshan Cui, Song Wu

Turkish Journal of Medical Sciences

Background/aim: Hepatocellular carcinoma (HCC) ranks among the most prevalent malignancies worldwide and the third leading cause of cancer-related death. The TRIM (tripartite motif-containing) protein family members had been reported to be involved in carcinogenesis and tumor progression. Here we aimed to explore the expression profile of TRIM6 in HCC and investigate its clinical significance as well as underlying mechanisms. Materials and methods: We retrospectively enrolled 138 HCC patients that underwent surgical resection in our hospital and tested protein expression level of TRIM6 through immunohistochemical staining. The correlation between TRIM6 and patients? characteristics was assessed by Chi-square test. Log-rank test and …

Predictors Of Two-Year Mortality In Patients With Dementia With Lewy Bodies, Nesli̇han Kayahan Satiş, Mehmet İlki̇n Naharci

Turkish Journal of Medical Sciences

Background/aim: Data on adverse prognostic factors for mortality in patients with dementia with Lewy bodies (DLB) are limited. The objective of this study was to evaluate two-year mortality predictors in patients with DLB. Materials and methods: Individuals aged ≥ 60 years with a diagnosis of DLB, followed by a tertiary-referral geriatric outpatient clinic from 2006 to 2021, were assessed retrospectively using medical or patient records. The mortality status of the patients in the second year after diagnosis was determined. Demographic and clinical characteristics were reviewed to determine their impact on mortality prediction. Results: A total of 108 patients with DLB …

The Possible Relation Between Temporal Muscle Mass And Glioblastoma Multiforme Prognosis Via Sarcopenia Perspective, Osman Sütcüoğlu, Zeynep Sezgi̇ Erdal, Orhun Akdoğan, Emrah Çelti̇kçi̇, Nuri̇ye Özdemi̇r, Ahmet Özet, Murat Uçar, Ozan Yazici

Turkish Journal of Medical Sciences

Background and aim: The optimal sarcopenia measurement method in patients with a diagnosis of glioblastoma multiforme (GBM) is unknown. It has been found that temporal muscle thickness (TMT) may reflect sarcopenia and be associated with survival, but the relationship between temporal muscle area (TMA) and GBM prognosis has never been evaluated before. The primary outcome of the study was to evaluate the relationship between TMA/TMT and overall survival (OS) time in newly diagnosed GBM patients. Materials and methods: The data of patients who presented at the university hospital between January 2009 and January 2019 with a confirmed diagnosis of glioblastoma …

Crm1 Expression: Association With High Prognostic Value In Laryngeal Cancer, Tali̇h Özdaş, Si̇bel Özdaş, İpek Canatar, Erdal Coşgun, Eli̇f Burcu Şenyurt, Orhan Görgülü

Turkish Journal of Medical Sciences

Background/aim: Laryngeal cancer is a very common malignant tumor of the head and neck. While laryngeal cancer does not show any obvious early symptoms, it tends to have a poor prognosis in advanced clinical stages. Chromosome region maintenance 1 (CRM1) mediates the nuclear export of some RNAs, major and tumor suppressor proteins and has been associated with the pathogenesis of many tumors. However, the clinicopathological significance of CRM1 gene expression in laryngeal cancer has not been clarified yet. Therefore, this study aims to detect the expression of CRM1 in laryngeal cancer and to investigate its relationship with clinicopathological parameters and …

Serum Alpha-1-Antitrypsin Level In The Severity Prognosis Of Systemic Lupus Erythematosus Patients: Systematic Exploration Of Novel Biomarker, Supaporn Khamchun Dr., Chunyanuch Thakaeng Miss, Rattikan Na Lampang Miss

BioMedicine

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affecting multi-organs injury and failure. The rapid, precision, and specificity prognosis by laboratory investigations could prevent active stage and severity in the disease.

Aims: To systematically explore and investigate the candidate serum protein for development into the novel biomarker for severity prognosis of SLE patients.

Methods: The proteins previously reported in abnormal level in serum/plasma of SLE patients since 2014-2020 were comprehensive collected. Thereafter, these serum proteins that found in other diseases were excluded. The association with molecules related to SLE severity of these candidate proteins were then …

Circular Rna Circprmt5 Is Upregulated In Breast Cancer And Is Required For Cellproliferation And Migration, Xiaofeng Li, Dairong Zhang, Zuxi Feng, Xiangjing Xu, Jihong Zhang, Aiping Yu, Li Zhu, Jie Xiao, Junhua Du, Min Chen

Turkish Journal of Medical Sciences

Background/aim: To evaluate the role of cyclic protein arginine methyltransferase 5 (circPRMT5) in the occurrence and development of breast cancer (BC). Materials and methods: A total of 90 BC patients who underwent radical mastectomy and 40 age-matched healthy female controls were recruited in the Second People's Hospital of China Three Gorges University, Yichang Second People's Hospital from 2017 to 2020. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to detect the expression levels of circPRMT5 in BC tissues, serum, normal breast cell line (MCF-10A), and BC cell line (T47D, MCF-7, BT549, Hs-578T, and MDA-MB-231, MDAMB-468). The associations between circPRMT5 …

Clinically Mild Encephalitis/Encephalopathy With A Reversible Splenial Lesion Of Thecorpus Callosum In Childhood: A Single-Center Experience, Hali̇l Çeli̇k, Betül Emi̇ne Deri̇nkuyu, Erhan Aksoy, Ülkühan Öztoprak, Nesri̇n Ceylan, Ebru Azapağasi, Suna Özdem, Melahat Melek Oğuz, Deni̇z Yüksel

Turkish Journal of Medical Sciences

Background/aim: Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a rare clinicoradiological syndrome that typically presents with central nervous system symptoms such as loss of consciousness, seizure, headache, and ophthalmoparesis. Materials and methods: Here, we highlight the characteristics of this syndrome together with the clinical and MRI findings of 6 pediatric patients with MERS. Results: Between January 2017 and October 2020, 6 patients with MERS (3 boys and 3 girls) presented to our center. The mean age was 122 ± 54.6 (min-max: 44-180) months. None of the patients had a chronic disease. In our study, infectious agents were detected …

Pd-L1 And Ebv Lmp1 Expressions In Classic Hodgkin Lymphomas And Its Correlation With Clinicopathological Parameters And Prognosis, Süleyman Özdemi̇r, Özlem Ton, Fevzi̇ye Kabukcuoğlu

Turkish Journal of Medical Sciences

Background/aim: Programmed death pathway leads to T cell anergy. Wide range of malignancies take advantage of this pathway by programmed death-ligand 1 (PD-L1) expression either on neoplastic cells or on the nonneoplastic cells of tumour microenvironment. New therapeutic approaches have been directed against this pathway. We studied PD-L1 expression on both neoplastic Hodgkin and Reed-Sternberg (HRS) cells and cells of tumour microenvironment in classic Hodgkin lymphoma (CHL) patients and compared it with Ebstein-Barr virus (EBV) positivity, clinical data, and survival rates. Materials and methods: Lymph node excision materials of 56 CHL patients diagnosed between 2007 and 2017 were included in …

Effect Of Perioperative Factors On The Prognosis Of Patients With Hepatocellular Carcinoma Who Underwent Hepatectomy, Lining Xu, Yingying Xu, Guiping Li, Bo Yang

Turkish Journal of Medical Sciences

Background/aim: Hepatic resection is a potentially curative treatment for patients with hepatocellular carcinoma (HCC). Controversy persists regarding preoperative and intraoperative characteristics related to patient survival in various medical institutes. This study aimed to evaluate the impact of preoperative and intraoperative factors on the long-term survival of patients with HCC who underwent hepatectomy. Materials and methods: Data on 455 patients with HCC who underwent hepatectomy over a 20-year period were retrospectively reviewed. Univariate and multivariate Cox regression analyses were performed for preoperative- and intraoperative-related prognostic factors. Results: The 1-, 3-, 5-, and 10-year overall survival rates of patients with HCC who …

Cha2ds2-Vasc Score As A Prognostic Indicator In Patients With Atrial Fibrillation Undergoing Coronary Stenting, Jian-Yong Zheng, Dong-Tao Li, Yi-Gang Qiu, Yi-Xiong Huang, Zheng-Ming Xu, Li Zhao, Yu Chen, Yi Cao, Yi-Da Tang, Cheng-Jun Guo, Zhi-Min Ma, Yong-Quan Wu, Yan Jiao, Tian-Chang Li

Turkish Journal of Medical Sciences

Background/aim: Patients with atrial fibrillation (AF) and coronary stenting had a poor prognosis. This study aimed to assess the accuracy of CHA2 DS2 -VASc score for predicting and grading adverse clinical outcomes in this population. Materials and methods: We reviewed the clinical data of all patients with previously documented nonvalvular AF who underwent coronary stenting between January 2010 and June 2015 in 12 hospitals of Beijing, China. The study population was divided into three groups: 1) Low CHA2 DS2 -VASc score, ≦ 2 points, 2) Intermediate score, 3-4 points, and 3) High score, ≧ 5 points. Major adverse cardiac/cerebrovascular events …

Cerebrospinal Fluid Level Of Neurofilament Light Chain Is Associated With Increased Disease Activity In Neuro-Behçet's Disease, Zerri̇n Karaaslan, Eli̇f Şanli, Özlem Ti̇mi̇rci̇ Kahraman, Vuslat Yilmaz, Ece Akbayir, Gi̇zem Koral, Sema İçöz, Tuncay Gündüz, Cem İsmai̇l Küçükali̇, Murat Kürtüncü, Erdem Tüzün

Turkish Journal of Medical Sciences

Background/aim: Clinical exacerbations characterized with neurological symptoms are observed in around 10% of Behçet's disease (BD) patients and may culminate in severe disability. Although certain immunological factors have been associated with disease activity in neuro-Behçet's disease (NBD), biomarkers for monitoring the clinical outcome of NBD have not been properly investigated. Materials and methods: Levels of neurofilament light chain (NFL), homeobox protein Hox-B3 (HoxB3), and YKL-40 were measured in cerebrospinal fluid (CSF) samples of 23 parenchymal (n = 16) and nonparenchymal (n = 7) NBD patients obtained during NBD attacks by ELISA. Parameters of clinical progression and outcome were assessed for …

The Survival Outcomes And Prognostic Factors Of Hepatocellular Carcinoma Among Type 2 Diabetes Patients: A Two-Centre Retrospective Cohort Study, Noor Atika Azit, Shahnorbanun Sahran, Voon Meng Leow, Manisekar K. Subramaniam, Suryati Mokhtar, Azmawati Mohammed Nawi

Turkish Journal of Medical Sciences

Background/aim: To determine the survival outcomes and prognostic factors associated with hepatocellular carcinoma (HCC) survival in type 2 diabetes (T2D) patients. Materials and methods: This was a retrospective cohort study involving two hepatobiliary centres from January 1, 2012, to June 30, 2018. Medical records were analysed for sociodemographic, clinical characteristics, laboratory testing, and HCC treatment information. Survival outcomes were examined using the Kaplan?Meier and log-rank test. Prognostic factors were determined using multivariate Cox regression. Results: A total of 212 patients were included in the study. The median survival time was 22 months. The 1-, 3-, and 5-year survival rates were …

Is Conut Score A Prognostic Index In Patients With Diffuse Large Cell Lymphoma?, Gülsüm Akgün Çağliyan, Si̇bel Hacioğlu, Başak Ünver Koluman, Kadi̇r İlkkiliç, Ruki̇ye Nar, Mehmet Nuri̇ Başer, Asli Bozdemi̇r, Hande Şenol, Ni̇lay Şen Türk, Veysel Erol, Onurcan Yildirim, Ömer Çağliyan, Ni̇l Güler

Turkish Journal of Medical Sciences

Background/aim: The aim of the study was to evaluate the effect of Controlling Nutritional Status (CONUT) score on the prognosis in patients with diffuse large B-cell lymphoma (DLBCL). Materials and methods: The present study was a retrospective study. The CONUT score was calculated based on serum albumin, total cholesterol and lymphocyte levels. This study included a total of 266 patients, 131 (49.2%) were female and 135 (50.8%) were male. The median follow-up period was 51 months (range: 1-190). Results: The median age was 64 years. The cut off CONUT was 1.5. There was a significant difference between patients with high …

Interleukin-21: A Potential Biomarker For Diagnosis And Predicting Prognosis In Covid-19 Patients, Ni̇lüfer Ayli̇n Acet Öztürk, Ahmet Ursavaş, Asli Görek Di̇lektaşli, Ezgi̇ Demi̇rdöğen, Necmi̇ye Funda Coşkun, Dane Edi̇ger, Ayşe Esra Uzaslan, Di̇ğdem Yöyen Ermi̇ş, Mert Karaca, Orkun Eray Terzi̇, Merve Bayram, Di̇lara Ömer Topçu, Büşra Yi̇ği̇tli̇ler, Ahmet Yurttaş, Shahri̇yar Maharramov

Turkish Journal of Medical Sciences

Background/aim: COVID-19 patients have a wide spectrum of disease severity. Several biomarkers were evaluated as predictors for progression towards severe disease. IL-21 is a member of common γ-chain cytokine family and creates some specific effects during programming and maintenance of antiviral immunity. We aimed to assess IL-21 as a biomarker for diagnosis and outcome prediction in patients hospitalized with COVID-19. Materials and methods: Patients with a preliminary diagnosis of COVID-19 and pneumonia other than COVID-19 admitted to a tertiary care hospital were included consecutively in this comparative study. Results: The study population consisted of 51 patients with COVID-19 and 11 …

What Is The Predictive Value Of Preoperative Ca 125 Level On The Survival Rate Of Type 1endometrial Cancer?, Şafak Yilmaz Baran, Songül Alemdaroğlu, Gülşen Doğan Durdağ, Seda Yüksel Şi̇mşek, Fi̇li̇z Bolat, Fati̇h Köse, Hüsnü Çeli̇k

Turkish Journal of Medical Sciences

Background/aim: To investigate the utility of preoperative serum cancer antigen 125 (CA 125) levels in type 1 endometrial carcinoma (EC) as a marker for determining poor prognostic factors and survival. Material and methods: All patients with endometrial cancer, who had been treated between 2012 and 2020, were retrospectively reviewed, and finally, 256 patients with type 1 endometrium carcinoma were included in the study. The relationship between the clinicopathological characteristics, CA 125 level, and survival rates were analyzed. The cut-off value for the preoperative serum CA 125 level was defined as 16 IU/L. Results: The median serum CA 125 levels were …

The Prognostic Value Of Serum Levels Of A Proliferation-Inducing Ligand (April) Intreatment-Naïve Patients With Chronic Lymphocytic Leukemia, Si̇nem Ni̇hal Esatoğlu, Di̇lek Keski̇n, Ahmet Emre Eşkazan, Tuğrul Elverdi̇, Ayşe Sali̇hoğlu, Muhli̇s Cem Ar, Şeni̇z Öngören, Zafer Başlar, Yildiz Aydin, Hafi̇ze Uzun, Teoman Soysal

Turkish Journal of Medical Sciences

Background/aim: A proliferation-inducing ligand (APRIL) has been investigated as a prognostic marker in chronic lymphocytic leukemia (CLL) patients. However, there is no cut-off level for serum APRIL (sAPRIL) levels that predict time to treatment in CLL patients. Materials and methods: Between May and December 2012, 94 consecutive CLL patients and 25 healthy controls were assessed. sAPRIL levels were measured by ELISA. Demographic data and prognostic markers were obtained from the patients' files. Treatment-naïve patients were followed up for 6.5 years for any treatment need. Results: Patients were divided into 3 groups: Treatment-naïve (n = 47), chemotherapy receiving (n = 25), …

The Platelet To Lymphocyte Ratio Predicts Overall Survival Better Than The Neutrophil Tolymphocyte Ratio In Metastatic Renal Cell Carcinoma, Oktay Hali̇t Aktepe, Gürkan Güner, Deni̇z Can Güven, Taha Koray Şahi̇n, Fadi̇me Si̇nem Ardiç, Deni̇z Yüce, Şuayi̇b Yalçin, Mustafa Erman

Turkish Journal of Medical Sciences

Background/aim: The prognostic values of systemic inflammatory markers, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) on overall survival (OS) of metastatic renal cell carcinoma patients (mRCC) treated with tyrosine kinase inhibitors (TKI) remain unclear. Thus, the present study aimed to investigate the prognostic impact of these markers on OS of mRCC patients. Materials and methods: A total of 150 patients receiving TKIs were retrospectively analyzed. Progression-free survival and OS times were analyzed with the Kaplan-Meier method, and the log-rank test was used for comparison. Univariable and multivariable Cox regression models evaluated the impact of NLR and …

Prognostic Value Of The C-Reactive Protein To Albumin Ratio In Patients Undergoingprimary Percutaneous Coronary Intervention For St-Segment Elevation Myocardialinfarction, Özgür Söğüt, Tarik Akdemi̇r, Mehmet Mustafa Can

Turkish Journal of Medical Sciences

Background/aim: This study investigated whether baseline serum level of C-reactive protein (CRP)/albumin ratio is associated with infarct localization, number of vascular lesions, and in-hospital mortality in patients undergoing primary percutaneous coronary intervention (PCI) for acute ST elevation myocardial infarction (STEMI). Methods: The study population consisted of 116 patients diagnosed with STEMI. The CRP/albumin ratio at first admission, cardiac troponin-I (cTnI), PCI results, and clinical outcomes were recorded. Results: The mean CRP/albumin ratio, cTnI level, and mean number of vascular lesions were significantly higher in non-survivors than in survivors (p = 0.006, p = 0.004, and p = 0.007, respectively). Multivariate …

Appendectomy History Is Associated With Severe Disease And Colchicine Resistance In Adultfamilial Mediterranean Fever Patients, Erdal Bodakçi̇, Nazi̇fe Şule Yaşar Bi̇lge, Nuh Ataş, Berkan Armağan, Hasan Satiş, Alper Sari, Reyhan Bi̇li̇ci̇ Salman, Gözde Kübra Yardimci, Hakan Babaoğlu, Levent Kiliç, Mehmet Aki̇f Öztürk, Berna Göker, Şemi̇nur Haznedaroğlu, Umut Kalyoncu, Abdurrahman Tufan

Turkish Journal of Medical Sciences

Background/aim: Peritonitis attacks of Familial Mediterranean Fever (FMF) usually requires emergency medical admissions and it's hard to distinguish a typical abdominal attack from surgical causes of acute abdomen. Therefore, history of abdominal surgery, particularly appendectomy, is very common in patients with FMF. However, history of appendectomy might also give some clues about the course of FMF in the adulthood. This study was to determine whether the history of appendectomy help to anticipate disease course of FMF in the adulthood. Materials and methods: All patients recruited from FMF in Central Anatolia (FiCA) cohort, comprising 971 adult subjects. All patients fulfilled the …

Covid-19 Experience Of The Major Pandemic Response Center In The Capital: Results Ofthe Pandemic's First Month In Turkey, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Bi̇rcan Kayaaslan, Adalet Aypak, Ayşe Kaya Kalem, Fatma Eser, Burcu Özdemi̇r, Eli̇f Muki̇me Saricaoğlu, Müge Ayhan, Yeşi̇m Aybar Bi̇li̇r, Işil Özkoçak Turan, Deni̇z Erdem, Nevzat Mehmet Mutlu, Turan Buzğan, Bedi̇a Di̇nç

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to evaluate the epidemiological and clinical characteristics and parameters that determined the clinical course and prognosis of the COVID-19 patients admitted to Ankara City Hospital during the first month of the pandemic in Turkey. Materials and methods: SARS-CoV-2 PCR positive patients who were hospitalized between March 10 and April 10, 2020 were included. Results: Among 222 patients, mean age was higher in severe acute respiratory illness (SARI)/critical disease group (P < 0.001). Median time from illness onset to admission and presence of comorbidity, especially coronary artery disease and chronic obstructive pulmonary disease, were significantly higher in the SARI/critical disease group (P < 0.05). Cough and fever were the most common symptoms, while anosmia and loss of taste were observed in 8.6% and 7.7% patients, respectively. The mortality rate was 5.4%. A high neutrophil/lymphocyte ratio; low lymphocyte, monocyte, and platelet count; elevated liver enzymes; low GFR; and high levels of muscle enzymes, ferritin, and IL-6 on admission were found to be associated with SARI/critical disease (P < 0.05). Bilateral ground-glass opacity and patchy infiltration were more frequently seen in the SARI/critical disease group (P < 0.001). Patients older than 65 years had an 8-fold increased risk for development of SARI/critical disease. Conclusion: This cohort study regarding COVID-19 cases in Turkey reveals that older age, presence of comorbidity, bilateral infiltration on CT, high neutrophil/lymphocyte ratio, low monocyte and platelet count, elevated liver enzymes, low GFR, high levels of muscle enzymes, and high levels of ferritin and IL-6 on admission are predictors of SARI and severe disease.

Familial Mediterranean Fever, From Pathogenesis To Treatment: A Contemporary Review, Abdurrahman Tufan, Helen Lachmann

Turkish Journal of Medical Sciences

Familial Mediterranean fever (FMF) (OMIM #249100) is the most common hereditary autoinflammatory disease in the world. FMF is caused by gain of function mutations of MEFV gene which encodes an immune regulatory protein, pyrin. Over the last few years, we have witnessed several new developments in the pathogenesis, genetic testing, diagnosis, comorbidities, disease related damage and treatment approaches to FMF. Elucidation of some of the pathogenic mechanisms has led to the discovery of pathways involved in inflammatory, metabolic, cardiovascular and degenerative diseases. The use of next generation sequencing in FMF has revealed many new gene variants whose clinical significance may …

The Effect Of Technical Details Of Percutaneous Catheter Drainage On The Clinical Outcomes Of Infected Necrotizing Pancreatitis Patients, Zhi-Hua Zhang, Yi-Xuan Ding, Yu-Duo Wu, Chong-Chong Gao, Fei Li

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the effect of technical details of percutaneous catheter drainage (PCD) on the clinical outcomes of patients with infected necrotizing pancreatitis (INP).Materials and methods: A total of 44 INP patients treated in our hospital from October 2013 to October 2015 were included. The correlations of the first PCD treatment data and the clinical outcomes were analyzed.Results: The number of catheters was positively correlated with hospital readmission (r = 0.335, P = 0.032). Receiver operating characteristic curve analysis showed that patients with ? 3 catheters were more likely to have hospital readmission. Patients with pleural effusion …

High Nucleostemin Expression Has A Favorable Prognostic Effect On Gastric Carcinomas, Güneş Deni̇z Yildirim, Deni̇z Arik, Bülent Yildiz, Murat Di̇ncer, Necdet Fati̇h Yaşar, Özgül Paşaoğlu

Turkish Journal of Medical Sciences

Background/aim: Nucleostemin is a nuclear protein that maintains stem cell features and plays a role as a cell proliferation marker. It also participates in cell cycle regulation by interfering with other intracellular proteins. Recent reports have indicated that this protein plays a role in ribosomal biogenesis and genome protection. High expression level of nucleostemin has been reported in some cancer patients. However, the importance of nucleostemin in gastric cancer needs to be addressed. The aim of this study was to investigate nucleostemin expression in gastric cancer and the effects of this expression on prognosis. Materials and methods: Nucleostemin expression was …

Polycythemia Vera: Diagnosis, Clinical Course, And Current Management, Yahya Büyükaşik, Ridvan Ali̇, Muhli̇s Cem Ar, Mehmet Turgut, Aki̇f Seli̇m Yavuz, Güray Saydam

Turkish Journal of Medical Sciences

Very important developments related to polycythemia vera (PV) have occurred during the last two decades. The discovery of Janus kinase (JAK) 2 mutations has changed both the diagnosis and clinical management of PV. Currently JAK2 molecular testing is essential in the diagnostic work-up and JAK2 mutation positivity is a major diagnostic criterion. The discovery of JAK2 mutations suggested that abnormal JAK-STAT signaling was a pivotal feature in the pathogenesis of Philadelphia-negative myeloproliferative neoplasms. This idea led to the development of JAK inhibitors. Currently ruxolitinib, a JAK1/JAK2 inhibitor, is also approved for PV patients with hydroxyurea resistance or intolerance. International collaborations …

Prevalence And Prognosis Of Intracranial Stenosis In Acute Ischemic Stroke;A Single Center Registry From Turkey, Mi̇ne Hayri̇ye Sorgun, Volkan Yilmaz, Çağri Ulukan, Sabi̇ha Tezcan, Müge Kuzu, İnci̇ Şule Özer, Hafi̇ze Çotur, Sefer Rzayev, Anwar Rawandi, Canan Togay Işikay

Turkish Journal of Medical Sciences

Background/aim: Intracranial stenosis (ICS) is identified in 2.2%?70.4% of patients with ischemic stroke and transient ischemic attack. This study aimed to determine the prevalence of ICS in a single center registry from Turkey. Materials and methods: We reviewed the charts of 619 patients with acute ischemic stroke. ICS was defined as any ICS > 50% on cerebrovascular imaging. The demographic data, risk factors, NIHSS scores and C reactive protein level at admission, mortality in hospital, recurrent stroke, and mRS in the follow-up period were recorded. Results: A total of 72 (11.6%) patients with ICS (45 males (62.5%); mean age 68.3 ± …

Is Lower Uterine Segment Involvement A Prognostic Factor In Endometrial Cancer?, Sali̇m Erkaya, Murat Öz, Hasan Onur Topçu, Ali̇ Levent Şi̇rvan, Tayfun Güngör, Mehmet Mutlu Meydanli

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study is to investigate the prognostic significance of lower uterine segment (LUS) involvement in endometrial cancer (EC). Materials and methods: We reviewed the patients who were operated at our institution between July 2007 and March 2015 with the diagnosis of EC. Tumors localized in the corpus and involving the LUS or localized entirely in the LUS formed Group A, while tumors in the uterine corpus without LUS involvement formed Group B. Clinicopathological characteristics and survival of the patients were compared in both groups. Results: A total of 500 patients were included in the study. There …

The Role Of Apelin In The Assessment Of Response To Chemotherapyand Prognosis In Stage 4 Nonsmall Cell Lung Cancer, Si̇nem Özsari, Gürsel Çok, Ali̇ Veral, Ti̇mur Köse

Turkish Journal of Medical Sciences

Background/aim: Prediction of response to chemotherapy and prognosis bears clinical significance in patients with lung cancer. The aim of the study was to examine the association between apelin expression in tumor tissues and overall survival, progression-free survival, chemoresistance, and treatment response in stage 4 nonsmall cell lung cancer (NSCLC) patients undergoing chemotherapy. Materials and methods: A total of 81 patients who received chemotherapy due to a biopsy-documented diagnosis of NSCLC between 2004 and 2011 were retrospectively studied. Bronchoscopic biopsy samples were examined immunohistochemically. Results: Of the overall study population (n = 81), the mean age was 59.0 ± 9.2 years; …