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Full-Text Articles in Medicine and Health Sciences
Long Noncoding Rnas In Pancreas Cancer: From Biomarkers To Therapeutic Targets, Esra Güzel Tanoğlu, Seyfure Adigüzel, Alpaslan Tanoğlu, Zehra Betül Aydin, Güli̇zar Hocaoğlu, Samet Ebi̇nç
Long Noncoding Rnas In Pancreas Cancer: From Biomarkers To Therapeutic Targets, Esra Güzel Tanoğlu, Seyfure Adigüzel, Alpaslan Tanoğlu, Zehra Betül Aydin, Güli̇zar Hocaoğlu, Samet Ebi̇nç
Turkish Journal of Medical Sciences
Long noncoding RNAs (lncRNAs) are noncoding RNA molecules with a heterogeneous structure consisting of 200 or more nucleotides. Because these noncoding RNAs are transcribed by RNA polymerase II, they have properties similar to messenger RNA (mRNA). Contrary to popular belief, the term "ncRNA" originated before the discovery of microRNAs. LncRNA genes are more numerous than protein-coding genes. They are the focus of current molecular research because of their pivotal roles in cancer-related processes such as cell proliferation, differentiation, and migration. The incidence of pancreatic cancer (PC) is increasing around the world and research on the molecular aspects of PC are …
Is Cancer Risk Reduced In Multiple Sclerosis? Results From A Tertiary Referral Center, Yasemi̇n Bahar, Egemen Yildiz, Abdul Rasheed Bahar, Rana Karabudak
Is Cancer Risk Reduced In Multiple Sclerosis? Results From A Tertiary Referral Center, Yasemi̇n Bahar, Egemen Yildiz, Abdul Rasheed Bahar, Rana Karabudak
Turkish Journal of Medical Sciences
Background/aim: Multiple sclerosis (MS) patients may be protected against cancer because of increased immune surveillance. However, aberrant T/B cell functioning in MS may increase the risk of cancer. We aimed to compare the frequency of cancer among patients with MS with an appropriate control group matched by the variables such as age, gender, tobacco smoking history, body mass index (BMI), and family history of cancer. Materials and methods: The MS patients who were registered and followed up at the MS Center in Hacettepe University Hospitals and appropriately matched with controls were included. A self-administered questionnaire with links to the online …
Precision Medicine Advancements In Glioblastoma: A Systematic Review, Karan Iyer, Shubham Saini, Suman Bhadra, Sohini Kulavi, Jaya Bandyopadhyay
Precision Medicine Advancements In Glioblastoma: A Systematic Review, Karan Iyer, Shubham Saini, Suman Bhadra, Sohini Kulavi, Jaya Bandyopadhyay
BioMedicine
Background. Glioblastoma multiforme, commonly known as GBM or glioblastoma is a grade IV astrocytoma. Brain tumors are difficult to treat and lead to poor prognosis and survival in patients. Gliomas are categorized into four different grades among which GBM is the worst grade primary brain tumor with a survival of less than a year. The genomic heterogeneity of the brain tumor results in different profiles for patients diagnosed with glioblastoma. Precision medicine focuses on this specific tumor type and suggests specialized treatment for better prognosis and overall survival (OS). Purpose. With the recent advancements in Genome-Wide Studies (GWS) and various …
The Effect Of Hydrochlorothiazide On The Recurrence Of Nonmelanoma Skin Cancer: A 7-Year Retrospective Study Comprising 300 Patients, Burak Özkan, Süleyman Savran, Kadri̇ Akinci, Abbas Albayati̇, Pinar İncel Uysal, Ahmet Çağri Uysal
The Effect Of Hydrochlorothiazide On The Recurrence Of Nonmelanoma Skin Cancer: A 7-Year Retrospective Study Comprising 300 Patients, Burak Özkan, Süleyman Savran, Kadri̇ Akinci, Abbas Albayati̇, Pinar İncel Uysal, Ahmet Çağri Uysal
Turkish Journal of Medical Sciences
Background/aim: Hydrochlorothiazide (HCTZ) possesses well-described photosensitizing properties, and a causal association with nonmelanoma skin cancer (NMSC) was recently shown. However, previous studies have not shown whether HCTZ use is associated with the risk of recurrence of basal cell carcinoma (BCC) or squamous cell carcinoma (SCC). This study aims to investigate the association between HCTZ use and recurrence in patients with NMSC. Materials and methods: We identified cases with NMSC from our hospital archives during the period between 2013 and 2019. Patients were divided into groups according to the pathological diagnosis, HCTZ use, and recurrence. Multivariable analysis was performed to determine …
Full Issue: The International Undergraduate Journal Of Health Sciences, Volume 1, Issue 1, June 2021
Full Issue: The International Undergraduate Journal Of Health Sciences, Volume 1, Issue 1, June 2021
International Undergraduate Journal of Health Sciences
The full June 2021 issue (Volume 1, Issue 1) of the International Undergraduate Journal of Health Sciences
Increased Incidence Of Malignancy In Patients With Primary Hyperparathyroidism, Meli̇a Karaköse, Muhammet Kocabaş, Mustafa Can, Hati̇ce Çalişkan Burgucu, İlker Çordan, Mustafa Kulaksizoğlu, Feri̇dun Karakurt
Increased Incidence Of Malignancy In Patients With Primary Hyperparathyroidism, Meli̇a Karaköse, Muhammet Kocabaş, Mustafa Can, Hati̇ce Çalişkan Burgucu, İlker Çordan, Mustafa Kulaksizoğlu, Feri̇dun Karakurt
Turkish Journal of Medical Sciences
Background/aim: Primary hyperparathyroidism (PHPT) is a disease that is diagnosed more frequently and generally in the asymptomatic period, with widely available biochemical tests. Evidence suggesting an association between PHPT and malignancy risk is increasing. Clarification of this association will be useful in PHPT for malignancy screening and management of patients with PHPT. In this study, we aimed to investigate the frequency of cancer in PHPT patients. Materials and methods: A total of 775 PHPT patients were included in the retrospective study. Demographic, clinical and laboratory data of the patients were evaluated retrospectively. Results: Malignancy was detected in 128 (16.50%) of …
How Can We Stop Cancer?, Joseph R. Current
How Can We Stop Cancer?, Joseph R. Current
The Review: A Journal of Undergraduate Student Research
Cancer is a disease that humans have been struggling to combat for centuries. It originates from the accumulation of several mutations over the life of a cell that causes it to evade cell death and multiply rapidly. It can affect any tissue in the body and can spread to other parts of the body through metastasis. Cancer comes in numerous shapes and sizes with different levels of aggression, growth speeds, and health risks. Many treatments for cancer exist today, three of the most popular being surgery, chemotherapy, and radiation therapy, which can be used in combinations with other treatments to …
Posttraumatic Growth And Death Anxiety In Caregivers Of Cancer Patients: Phoenix Study, Ali̇ Alkan, Eli̇f Berna Köksoy, Ebru Karci, Asli Alkan, Eduardo Bruera, Fi̇li̇z Çay Şenler
Posttraumatic Growth And Death Anxiety In Caregivers Of Cancer Patients: Phoenix Study, Ali̇ Alkan, Eli̇f Berna Köksoy, Ebru Karci, Asli Alkan, Eduardo Bruera, Fi̇li̇z Çay Şenler
Turkish Journal of Medical Sciences
Background/aim: Posttraumatic growth (PTG) is defined as positive psychological changes following a challenging or traumatic life event. The purpose of this study is to define the predictors of PTG and death anxiety (DAN) in caregivers of cancer patients and evaluate the impact of DAN on PTG.Materials and methods: The caregivers of cancer patients were evaluated using structured questionnaires, including a validated PTG scale and Templer death anxiety scale.Results: In 3 different cancer centers, 426 participants were evaluated. In multivariate analysis of factors associated with PTG, a high DAN score was the only parameter associated with high PTG scores [OR: 1.6, …
Immune Gene Therapy Of Cancer, Hakan Akbulut
Immune Gene Therapy Of Cancer, Hakan Akbulut
Turkish Journal of Medical Sciences
Cancer gene therapy emerged as a promising treatment modality 3 decades ago. However, the failure of the first gene therapy trials in cancer treatment has decreased its popularity. Likewise, immunotherapy has followed a similar course. While it was a popular and promising treatment with IL-2 and interferon and cancer vaccines in the 1980s, it later lost its popularity. Immunotherapy became one of the main options for cancer treatment with the successful use of immune checkpoint inhibitors in clinics approximately 10 years ago. The success of immunotherapy has increased even more with the introduction of cancer gene therapy methods in this …
Developing Drug Therapies: Cognitive Damage In Mice Following Brain Radiation, Rachel Yuska
Developing Drug Therapies: Cognitive Damage In Mice Following Brain Radiation, Rachel Yuska
The Journal of Purdue Undergraduate Research
Pediatric brain cancer patients are at a high risk for radiation-induced cognitive impairment due to white matter changes in the brain. Half of six-month radiotherapy survivors develop significant changes in white matter. Previous research has shown that a mouse model can be used to show similar cognitive and behavioral deficits in human patients. The purpose of this work is to evaluate the effectiveness of two drug therapies, Donepezil and 3,3-Diindolylmethane (DIM), that could be used to either protect the brain from radiation injury or cure the cognitive injury and behavioral deficits that result from whole-brain irradiation. This project consisted of …
Prognostic Value Of Interferon-Gamma, Interleukin-6, And Tumor Necrosis Factor-Alpha In The Radiation Response Of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer And Glioblastoma Multiforme, Çi̇ğdem Damla Deni̇z, Mehmet Gürbi̇lek, Mehmet Koç
Prognostic Value Of Interferon-Gamma, Interleukin-6, And Tumor Necrosis Factor-Alpha In The Radiation Response Of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer And Glioblastoma Multiforme, Çi̇ğdem Damla Deni̇z, Mehmet Gürbi̇lek, Mehmet Koç
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the effect of chemoradiotherapy (CRT) on interferon-gamma (IFN-γ), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), which are critical markers of the clinical radiation response of patients with locally advanced non-small-cell lung cancer (NSCLC) and glioblastoma multiforme (GBM). Materials and methods: Thirty patients who were treated with CRT and 20 healthy controls were prospectively evaluated. Circulating levels of cytokines were measured by enzyme-linked immunosorbent assay procedure. Post-CRT and pre-CRT levels were compared. Results: Post-CRT, TNF-α and IFN-γ levels were significantly lower than pre-CRT levels in the NSCLC and GBM groups, respectively. The statistical analysis did …
Predictors Of Mortality In Cancer Patients Who Needintensive Care Unit Support: A Two Center Cohort Study, Özlem Edi̇boğlu, Sami̇ Cenk Kirakli, Özlem Yazicioğlu Moçi̇n, Gökay Güngör, Ceyda Anar, Pinar Çi̇men, Nalan Adigüzel, Cüneyt Saltürk, Meri̇h Kalamanoğlu Balci, Zuhal Karakurt, Dursun Ali̇zoroğlu
Predictors Of Mortality In Cancer Patients Who Needintensive Care Unit Support: A Two Center Cohort Study, Özlem Edi̇boğlu, Sami̇ Cenk Kirakli, Özlem Yazicioğlu Moçi̇n, Gökay Güngör, Ceyda Anar, Pinar Çi̇men, Nalan Adigüzel, Cüneyt Saltürk, Meri̇h Kalamanoğlu Balci, Zuhal Karakurt, Dursun Ali̇zoroğlu
Turkish Journal of Medical Sciences
Background/aim: Cancer patients frequently need intensive care support due to respiratory failure. We aimed to evaluate the predictors of mortality in cancer patients who were admitted to the intensive care unit (ICU). Materials and methods: This study was performed in the ICUs of two centers between 1 January 2008 and 31 December 2015. Demographic data, cancer type, causes of respiratory failure, comorbidities, APACHE II scores, treatments, and mortality rates were recorded. Results: A total number of 583 cancer patients (477 males) were enrolled from the two centers. Of those, 472 patients had lung cancer (81%), while 111 had extrapulmonary malignancies …
Investigation Of Moringa Oleifera Leaf Extract And Its Cancer-Selective Antiproliferative Properties, Reagen H. Welch, Ashlee H. Tietje
Investigation Of Moringa Oleifera Leaf Extract And Its Cancer-Selective Antiproliferative Properties, Reagen H. Welch, Ashlee H. Tietje
Journal of the South Carolina Academy of Science
Moringa oleifera is a tree native to a number of Asian, African, and Central American countries and has been used in traditional medicine for an assortment of medicinal uses for centuries. Due to bioactive compounds within Moringa leaves, it is believed that Moringa leaf extract may possess cancer-selective antiproliferative properties. Previous research has been conducted in regards to this topic, but poor experimental design due to lack of necessary controls limits the legitimacy of anticancer claims. While previous research has shown that Moringa leaf extract has the potential to kill cancer cells, the research fails to demonstrate the effects of …
Natural Killer (Nk) Cells And Their Involvement In Different Types Of Cancer. Current Status Of Clinical Research, Isadora Zaharescu, Adina D. Moldovan, Cristiana Tanase
Natural Killer (Nk) Cells And Their Involvement In Different Types Of Cancer. Current Status Of Clinical Research, Isadora Zaharescu, Adina D. Moldovan, Cristiana Tanase
Journal of Mind and Medical Sciences
Natural killer cells are the main agents of innate immunity. Since 1970, various studies have repeatedly confirmed their involvement in decreasing local tumor growth and also decreasing the risk of metastasis, due to their cytotoxic effects and also through the release of immunostimulatory cytokines such as IFN-gamma. In the 1990s, several studies demonstrated the existence of certain inhibiting and stimulating receptors of these cells, leading to the concept of “induced self”, thus explaining why tumors with MHC-1 are destroyed and autologous cells without it are saved out. Recognition and destruction of tumor cells by the NK cells are the result …
Is Gene Therapy A Viable Option For Cancer Treatment?, Aliza Applebaum
Is Gene Therapy A Viable Option For Cancer Treatment?, Aliza Applebaum
The Science Journal of the Lander College of Arts and Sciences
The use of gene therapy as a medical treatment option was first introduced to the world in 1990, when a four-year-old girl became its first patient. Since then gene therapy has met great success but also severe drawback. Incidences with severely negative outcomes on patients gave gene therapy a bad name and many began skeptical towards its use, but the constant work and progress on the safety and effectiveness of gene therapy is making it a more viable route of treatment. This paper focuses on gene therapy as a form of cancer treatment. Viral insertion of the modified genetic material …
A Prospective Follow-Up Of Quality Of Life, Depression, Andanxiety In Children With Lymphoma And Solid Tumors, Ni̇hal Sargin Yildirim, Meti̇n Demi̇rkaya, Betül Berri̇n Sevi̇ni̇r, Sali̇h Güler, Ayşe Pinar Vural, Candan Demi̇röz, Arzu Çirpan Kantarcioğlu
A Prospective Follow-Up Of Quality Of Life, Depression, Andanxiety In Children With Lymphoma And Solid Tumors, Ni̇hal Sargin Yildirim, Meti̇n Demi̇rkaya, Betül Berri̇n Sevi̇ni̇r, Sali̇h Güler, Ayşe Pinar Vural, Candan Demi̇röz, Arzu Çirpan Kantarcioğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was the determination and prospective follow-up of quality of life, depression, and anxiety in pediatric patients with cancer under chemotherapy, as well as the evaluation of related factors. Materials and methods: Fifty newly diagnosed pediatric cancer patients and their parents were prospectively monitored before, during, and after therapy, and tests were used. Results: Significantly lower quality of life scores were recorded during treatment, in the group with CNS tumors, in the group receiving chemotherapy plus radiotherapy plus surgery, in the inpatient-only treatment group, in the group receiving treatment for longer than 6 months, and …
Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd
Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd
Marshall Journal of Medicine
Vitamin K is known to play an essential role in the coagulation cascade; however, a growing body of research has found that a subtype of this vitamin, vitamin K2 (menaquinone) may have a beneficial effect in osteoporosis, cardiovascular disease, and cancer. This purpose of this article is to provide a comprehensive review of recent literature regarding menaquinone and its role in human health. This review discusses the physiology of menaquinone, its clinical benefits in cardiovascular disease, osteoporosis, and cancer, and how it may interact with certain medications. The authors conclude that menaquinone supplementation has been shown to improve carboxylation …
The Effect Of Enteral Immunonutrition In Upper Gastrointestinalsurgery For Cancer: A Prospective Study, Seli̇m Yi̇ği̇t Yildiz, Murat Burç Yazicioğlu, Çağri Ti̇ryaki̇, Ali̇ Çi̇ftçi̇, Zehra Boyacioğlu, Mehmet Özyildiz, Murat Coşkun, Özkan Subaşi
The Effect Of Enteral Immunonutrition In Upper Gastrointestinalsurgery For Cancer: A Prospective Study, Seli̇m Yi̇ği̇t Yildiz, Murat Burç Yazicioğlu, Çağri Ti̇ryaki̇, Ali̇ Çi̇ftçi̇, Zehra Boyacioğlu, Mehmet Özyildiz, Murat Coşkun, Özkan Subaşi
Turkish Journal of Medical Sciences
Background/aim: Enteral feeding and immunonutrition (ImN) have been shown to be associated with a number of favorable effects in patients undergoing cancer surgery. In this prospective study, we aimed to assess the perioperative use of enteral immunonutrition in patients undergoing radical gastrointestinal surgery for malignancy. Materials and methods: Forty-one patients with malignancy were included in this study and were randomized into one of the two following nutritional strategies: enteral only (EN) or enteral with enteral immunonutrition (ENIN). These regimens were followed for 7 days perioperatively by all patients. Nutritional parameters and postoperative morbidity, mortality, and length of hospital stay (LHS) …
Epidemiology And Cost Of Drug Treatment Of Cancer In Northern Cyprus, Ayşe Gökyi̇ği̇t, Seyi̇de Rumeysa Demi̇rdamar
Epidemiology And Cost Of Drug Treatment Of Cancer In Northern Cyprus, Ayşe Gökyi̇ği̇t, Seyi̇de Rumeysa Demi̇rdamar
Turkish Journal of Medical Sciences
Background/aim: To determine the epidemiology, the sociodemographic features, the incidence and prevalence rate of cancer, and the cost of drug treatment in Northern Cyprus. Materials and methods: All of the oncology prescriptions, cancer pathology reports, and cancer referrals to overseas for 2011 were collected from the state hospitals, the only private university hospital that provides oncology services, and the Ministry of Health to prepare an epidemiological database. The total cost of drug treatment at the state hospitals and cost of the most frequent five cancer types were also calculated using the therapy protocols and the expense of the drugs. Results: …
The Incidence Of 18f-Fdg Pet/Ct Thyroid Incidentalomas Andthe Prevalence Of Malignancy: A Prospective Study, Mi̇ne Şencan Eren, Özhan Özdoğan, Arzu Gedi̇k, Mehmet Ceylan, Meri̇h Güray Durak, Mustafa Seçi̇l, Mehmet Ali̇ Koçdor, Abdurrahman Çömlekçi̇, Hati̇ce Durak
The Incidence Of 18f-Fdg Pet/Ct Thyroid Incidentalomas Andthe Prevalence Of Malignancy: A Prospective Study, Mi̇ne Şencan Eren, Özhan Özdoğan, Arzu Gedi̇k, Mehmet Ceylan, Meri̇h Güray Durak, Mustafa Seçi̇l, Mehmet Ali̇ Koçdor, Abdurrahman Çömlekçi̇, Hati̇ce Durak
Turkish Journal of Medical Sciences
Background/aim: To determine the prevalence of malignancy in thyroid incidentalomas (TIs) detected by fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). Materials and methods: 18F-FDG PET/CT images were evaluated prospectively for the presence of thyroid uptake. The patients with a TI were evaluated by an endocrinologist according to the predefined diagnostic algorithm. The final diagnosis was obtained clinically and/or by pathology. Results: TI was detected in 4.2% of 4204 patients. A malignant thyroid nodule was diagnosed in 29% and 33% of the focal and diffuse-focal uptake groups, respectively. However, no malignancy was detected in the diffuse uptake group. The standardized …
Pacaha Inhibits Proliferation Of Human Cancer Cells In Vitro, Sali̇ha Ekşi̇, Nebahat Ejder, Fati̇h Yilmaz, Ayşe Ertürk, Cemal Sandalli
Pacaha Inhibits Proliferation Of Human Cancer Cells In Vitro, Sali̇ha Ekşi̇, Nebahat Ejder, Fati̇h Yilmaz, Ayşe Ertürk, Cemal Sandalli
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the antiproliferative and cytotoxic effects of a newly synthesized molecule named paracetamol acetohydroxamic acid (PaCaHa) on human neoplastic cell lines. Materials and methods: A549, CRL 2923, HeLa, and ARPE were treated with various concentrations of PaCaHa and DMSO (vehicle control). The cytotoxic/cytostatic effects of PaCaHa were determined after a 24-h incubation period and compared to the DMSO control. The cytotoxic and antiproliferative effects were determined by the trypan blue dye exclusion and MTT methods. Results: A higher susceptibility to PaCaHA was found in CRL 2923 and HeLa cells, while A549 and …
Management Of Acute Postoperative Hypertension For Reducing Cardiovascular Complications In Cancer Patients: When And How Aggressively?, Ning Lou, Daofeng Wang, Zhi Wang, Wenfeng Ye, Xiao Liu
Management Of Acute Postoperative Hypertension For Reducing Cardiovascular Complications In Cancer Patients: When And How Aggressively?, Ning Lou, Daofeng Wang, Zhi Wang, Wenfeng Ye, Xiao Liu
Turkish Journal of Medical Sciences
Background/aim: We sought to determine what factors cardiovascular complications (CVCs) correlate with in cancer patients with acute postoperative hypertension (APH) and to define when and how aggressively to treat this disorder in the present study. Materials and methods: A retrospective observational study of cancer patients with postoperative hypertension at a single intensive care unit between July 2007 and June 2013 was conducted. The outcome of interest was the incidence of a CVC. Results: There were 1162 patients enrolled, of which 92 (7.9%) experienced one or more CVCs. Preexisting hypertension (OR 38.3, 95% CI 3.2-457.4, P = 0.004) and choice of …
Epigenetics As A Cure For Cancer, Sara Rivka Margolis
Epigenetics As A Cure For Cancer, Sara Rivka Margolis
The Science Journal of the Lander College of Arts and Sciences
Epigenetics is an emerging research topic that is being tested as a potential cure for cancer. Epigenetics is a non-genetic influence that shapes the phenotype. Epigenetics effects gene expression, but does not cause any changes in the DNA. DNA methylation patterns is one such epigenetic change in the cell that has huge potential for cancer treatment. Scientists have observed that many cancerous genes express signs of either hypermethylation or hypomethylation. The key for the treatment is that epigenetic changes are reversible, which opens the door to potential drugs to cure cancer and other diseases.
Transposon Based Gene Therapy As A Treatment For Cancer, Jacob Stauber
Transposon Based Gene Therapy As A Treatment For Cancer, Jacob Stauber
The Science Journal of the Lander College of Arts and Sciences
Gene therapy is the use of genes to treat or prevent diseases. Diseases such as cancer, which are difficult to treat using conventional methods, can be treated using gene therapy. The transport of the therapeutic transgene can be accomplished using viral or non-viral methods. However, widespread use of viral vectors is limited due to its high cost of manufacture and safety concern. Non-viral vectors are limited in their effectiveness. The use of transposons such as the Sleeping Beauty transposon system can effectively deliver the transgene with less concern than viral vectors. This review discusses the various vectors and treatment strategies …
Parp Inhibition: A Method Of Treating And Preventing Certain Cancers, Chana Tropper
Parp Inhibition: A Method Of Treating And Preventing Certain Cancers, Chana Tropper
The Science Journal of the Lander College of Arts and Sciences
Breast cancer is one of the largest causes of cancer related deaths in women. Less than 5% of breast cancer cases are genetically inherited and most often develop after menopause. The BRCA gene mutation is a genetic inheritance which increases ones chances of developing breast cancer at a young age tenfold. Recent research has proposed a method of treatment in genetically inherited breast cancers by taking advantage of the impaired DNA repair pathway caused by the BRCA mutation. The combination of a BRCA mutation, which leads to deficient double strand DNA repair, and PARP inhibition, which leads to deficient single …
Attachment Style And Perceived Social Support As Predictors Of Biopsychosocial Adjustment To Cancer, Ayşe Gül Yilmaz Özpolat, Tuğba Ayaz, Özlem Konağ, Asi̇ye Özkan
Attachment Style And Perceived Social Support As Predictors Of Biopsychosocial Adjustment To Cancer, Ayşe Gül Yilmaz Özpolat, Tuğba Ayaz, Özlem Konağ, Asi̇ye Özkan
Turkish Journal of Medical Sciences
Social support is associated with a decrease in psychological symptoms and a better quality of life in cancer patients. The aim of this study was to investigate the role of attachment dimensions on social and psychological adjustment to cancer and to explore the social and psychological adjustments, and medical adherence, among patients. Materials and methods: The study was conducted with 68 cancer patients, between 18 and 74 years of age. The measures taken were the Demographic Information Form, Multidimensional Scale of Perceived Social Support (MSPSS), Experiences in Close Relationships-Revised (ECR-R), and Psychosocial Adjustment to Illness Scale (PAIS-SR). Results: The results …
Oxaliplatin And Ototoxicity: Is It Really Safe For Hearing?, Sali̇m Yüce, Mehmet Meti̇n Şeker, Sema Koç, İsmai̇l Önder Uysal, Turgut Kaçan, Mehtap Doğan, Mansur Doğan, Nalan Akgül Babacan, Saadetti̇n Kiliçkap
Oxaliplatin And Ototoxicity: Is It Really Safe For Hearing?, Sali̇m Yüce, Mehmet Meti̇n Şeker, Sema Koç, İsmai̇l Önder Uysal, Turgut Kaçan, Mehtap Doğan, Mansur Doğan, Nalan Akgül Babacan, Saadetti̇n Kiliçkap
Turkish Journal of Medical Sciences
Oxaliplatin is an effective and widely used chemotherapeutic agent in the treatment of many solid tumors. The most common side effects are peripheral neuropathy, gastrointestinal toxicity, and neutropenia. There have been some case reports about ototoxicity with oxaliplatin, but no clinical trials. In this trial, we explored whether or not oxaliplatin has ototoxic effects. Materials and methods: A total of 18 patients, 14 with colorectal cancer and 4 with pancreatic cancer, were included in this study. Four patients (22%) were treated with a capecitabine and oxaliplatin (CapeOx) regimen, and 14 patients (78%) were treated with fluorouracil, leucovorin, and oxaliplatin (FOLFOX-6). …
The Causes Of Deaths In An Industry-Dense Area: Example Of Dilovası (Kocaeli)*, Onur Hamzaoğlu, Ni̇lay Eti̇ler, Cavi̇t Işik Yavuz, Çi̇ğdem Çağlayan
The Causes Of Deaths In An Industry-Dense Area: Example Of Dilovası (Kocaeli)*, Onur Hamzaoğlu, Ni̇lay Eti̇ler, Cavi̇t Işik Yavuz, Çi̇ğdem Çağlayan
Turkish Journal of Medical Sciences
Chemical pollutants caused by the industry have changed both mortality rates and morbidity patterns causing new illnesses over the last few decades. This study aimed to determine the causes and characteristics of deaths related to cancer in 2004 in Dilovası, Kocaeli, which was mainly used as a production, storage, and transfer area for a variety of industries, such as chemical, metal and metal products, energy, and machinery. Materials and methods: In this cross-sectional study, death records of 8 different registry/record screenings belonging to 4 public institutions in Dilovası in 2004 were investigated. The study population included deaths in 2004 and …
Demographics, Clinical Presentations And Outcomes Of Cancer Patients Admitting To Emergency Department., Nuri̇ Bozdemi̇r, Oktay Eray, Cenker Eken, Yeşi̇m Şenol, Mehmet Artaç, Mustafa Samur
Demographics, Clinical Presentations And Outcomes Of Cancer Patients Admitting To Emergency Department., Nuri̇ Bozdemi̇r, Oktay Eray, Cenker Eken, Yeşi̇m Şenol, Mehmet Artaç, Mustafa Samur
Turkish Journal of Medical Sciences
Aim: The development of new treatment strategies for cancer patients resulted in an increase of cancer patient visits to emergency departments (EDs). The purpose of this study is to determine clinical characteristics, causes, and predictors of short term prognosis of cancer patient admissions to the ED. Materials and Methods: This prospective, clinical, and observational study was carried out in an adult ED of a tertiary hospital with an annual census of 55,000. All cancer patients visiting the ED within the 6-month period were enrolled into the study and followed up at the 1st and 3rd months afterwards. Records were based …
Pten Expression In Primary Prostate Carcinoma In Turkish Patients, Di̇lek Ertoy Baydar, Haluk Özen, Osman Saraçbaşi, Erdem Karabulut
Pten Expression In Primary Prostate Carcinoma In Turkish Patients, Di̇lek Ertoy Baydar, Haluk Özen, Osman Saraçbaşi, Erdem Karabulut
Turkish Journal of Medical Sciences
Aim: Prostatic adenocarcinoma shows remarkable variability in the incidence and biological behavior between populations from different races and geographical regions of the world. PTEN has been reported as the most commonly mutated tumor suppressor gene in prostate cancer. Incidence of PTEN alterations occurring in prostatic carcinoma has not been studied previously in the Turkish population. Materials and Methods: We examined PTEN protein expression immunohistochemically and its significance in 69 primary prostate cancer patients from Turkey. Two tissue microarrays constructed by 0.6 mm cores from radical prostatectomy specimens were used. Clinical information for all patients was obtained from hospital records. Results: …