Medicine and Health Sciences Commons^™

Initial Alpha-1 Antitrypsin Screening In Turkish Patients With Chronic Obstructive Pulmonary Disease, Seda Tural Önür

Turkish Journal of Medical Sciences

Background/aim: Alpha-1 antitrypsin (AAT) deficiency is associated with several types of pathology, and the reported effects of mutations in the ATT-encoding gene vary worldwide. No Turkish study has yet appeared. We thus explored the AAT status of Turkish patients with chronic obstructive pulmonary disease (COPD). Materials and methods: This prospective cross-sectional study included outpatients and inpatients treated from June 2021 to June 2022. Serum AAT levels were checked, and dry blood samples were subjected to genetic analysis. Results: Genetic mutations were found in 21 (3.52%) of 596 patients with prior and new COPD diagnoses treated in our pneumonology outpatient department. …

Emergency Ultrasound Of Respiratory Muscles: A Promising Tool For Determining The Outcomes Of Copd Exacerbations, Di̇nçer Yegi̇n, Alten Oskay, Tülay Oskay, Selcan Enver Di̇nç, Hande Şenol, Mert Özen, Vefa Çakmak, Murat Seyi̇t, Atakan Yilmaz, İbrahi̇m Türkçüer

Turkish Journal of Medical Sciences

Background/aim: The respiratory muscles of patients with chronic obstructive pulmonary disease (COPD) exhibit structural and functional changes that can be evaluated and monitored by ultrasonography. Materials and methods: This single-center, prospective study was conducted in the emergency department (ED) of a tertiary care hospital over an eight-month period (September 2020-May 2021). Diaphragmatic excursions, end-expiratory thickness, and thickening fractions, as well as right and left intercostal muscle thicknesses, of all adult subjects manifesting COPD exacerbation, were assessed. The data were analyzed regarding ward/intensive care unit (ICU) hospitalization or discharge from the ED, mortality, and readmission within 15 days. Results: Sixty-three subjects …

Risk Factor Analysis Of Hospital Readmissions At St. Petersburg General Hospital, Vincent Wu, Sean Quinonez, My Myers, Kyle Borodunovich, Aisha Shamsi, Patrick Stocker, Bryan Fink, Steven Ferreira

HCA Healthcare Journal of Medicine

Background

Decreased readmission rates are largely seen as an indicator of effective care and improved resource management. The case management team at St. Petersburg General Hospital in St. Petersburg, Florida identified chronic obstructive pulmonary disease (COPD) exacerbation, pneumonia, and sepsis as 3 of the leading diagnoses on index admission that later led to 30-day readmissions. By examining patients with these 3 diagnoses on index admission, we decided to investigate potential readmission risk factors including patient age, sex, race, body mass index (BMI), length of stay during the index admission, insurance type during index admission, discharge placement after index admission, coronary …

Long-Term Efficiency Of Pulmonary Rehabilitation In Patients With Chronic Obstructive Pulmonary Disease, Bronchiectasis, And Asthma: Does It Differ?, Mustafa Engi̇n Şahi̇n, Seher Satar, Pinar Ergün

Turkish Journal of Medical Sciences

Background and aim: The long-term effects of pulmonary rehabilitation (PR) and maintenance programs in obstructive pulmonary diseases have not been sufficiently investigated, particularly in diseases other than COPD. This retrospective study aimed to examine the long-term results of individualized comprehensive outpatient pulmonary rehabilitation in patients with obstructive pulmonary disease. Materials and methods: This study is a single-center, retrospective cohort study. Between 2010 and 2019, 269 patients with chronic airway obstruction were treated in our multidisciplinary PR center at a tertiary training and research hospital, and they were divided into three groups based on their diagnosis: COPD, bronchiectasis, and asthma. Patients' …

The Evaluation Of Disease Awareness, Caregiver Burden, And Workday Loss In Caregivers Ofcopd Patients, Ayşe Baha, Nurdan Köktürk, Burcu Öztürk Şahi̇n, Eli̇f Yildirim, İpek Özmen, Alev Gürgün, Ayşe Füsun Topçu, Evri̇m Eylem Akpinar, Funda Elmas Uysal, Hadi̇ce Seli̇moğlu Şen, Nalan Ogan, Yeşi̇m Önder, Ömer Tamer Doğan, Mehmet Polatli, Züleyha Bi̇ngöl

Turkish Journal of Medical Sciences

Background/aim: Our aim is to determine the caregiver burden of chronic obstructive lung disease (COPD) patient's caregivers, and to determine whether there is a workday loss. Materials and methods: 252 COPD patients and their caregivers were included. Disease information of the patients were recorded and a questionnaire was applied. Socio-demographic characteristics of the caregivers were recorded and a questionnaire consisting of 24 questions including COPD disease, treatment and loss of working days, and the Zarit Scale were used. Results: 128(50.8%) of the patients according to GOLD were group-D, 97(38.5%) of the patient's relatives were working, 62(24.7%) were not able to …

Examination Of Diaphragm Thickness, Mobility And Thickening Fraction In Individuals With Copd Of Different Severity, Ceyhun Topcuoğlu, Eylem Tütün Yümi̇n, Mustafa Hizal, Suat Konuk

Turkish Journal of Medical Sciences

Background/aim: Diaphragm thickness and mobility assessed by ultrasound in individuals with Chronic Obstructive Pulmonary Disease (COPD) reflect the function of the diaphragm. The aim of this study is to compare the diaphragm thickness, mobility, and thickening fraction in individuals with COPD of different severity and healthy individuals and examine the relationship between these parameters and pulmonary function test parameters. Materials and methods: A cross-sectional observational study design was used. Thirty individuals (mild = 11; moderate = 13; severe = 6) with COPD and 29 healthy male individuals aged between 40-75 years were included in the study. The individuals included in …

Chronic Obstructive Pulmonary Disease Phenotypes In Turkey: The Copet Study-A National, Multicenter Cross-Sectional Observational Study, Esra Yazar, Burcu Arpinar Yi̇ği̇tbaş, Can Öztürk, Mukadder Çalikoğlu, Gazi̇ Gülbaş, Muzaffer Onur Turan, Hülya Doğan Şahi̇n, Nurhan Sarioğlu, Nevi̇n Taci̇ Hoca, Fulsen Bozkuş, Seda Tural Önür, Ni̇hal Arzu Mi̇ri̇ci̇, Nalan Ogan, Ni̇lgün Yilmaz Demi̇rci̇, Burcu Yormaz

Turkish Journal of Medical Sciences

Background/aim: While mortality rates decrease in many chronic diseases, it continues to increase in COPD. This situation has led to the need to develop new approaches such as phenotypes in the management of COPD. We aimed to investigate the distribution, characteristics and treatment preference of COPD phenotypes in Turkey. Materials and methods: The study was designed as a national, multicenter, observational and cross-sectional. A total of 1141 stable COPD patients were included in the analysis. Results: The phenotype distribution was as follows: 55.7% nonexacerbators (NON-AE), 25.6% frequent exacerbators without chronic bronchitis (AE NON-CB), 13.9% frequent exacerbators with chronic bronchitis (AE-CB), …

Maintenance Of Pulmonary Rehabilitation Benefits In Patients With Copd: Is A Structured5-Year Follow-Up Program Helpful?, İpek Candemi̇r, Pinar Ergün, Mustafa Engi̇n Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Pulmonary rehabilitation (PR) has proven useful in patients with chronic obstructive pulmonary disease (COPD), but the benefits decrease over time. We evaluated the effects of a structured follow-up program after PR on patient pulmonary function, dyspnea, body composition, exercise capacity, quality of life, psychological status, i-BODE index, hospitalization status, 5-year survival rate. We explored whether this follow-up program could serve as a maintenance program. Materials and methods: COPD patients who completed PR attended follow-up visits over 5 years. We administered incremental (ISWT), endurance shuttle walk tests (ESWT), measured body (BMI), fat-free mass indices (FFMI), recorded modified Medical Research Council …

The Relationship Between Serum Levels Of Surfactant Protein D In Copd Exacerbation Severity And Mortality, Fatma Esra Günaydin, Nurdan Kalkan, Gülşah Günlüoğlu, Esma Nur Aktepe, Bariş Demi̇rkol, Sedat Altin

Turkish Journal of Medical Sciences

Background/aim: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. In COPD patients, various inflammatory markers such as cytokines and acute phase proteins, which show systemic inflammation in the circulation, increase during exacerbations. In our study, we aimed to determine the relationship between serum SP-D levels and exacerbation severity, clinical course of the disease, and early mortality after discharge.Materials and methods: Fifty hospitalized patients with COPD acute exacerbation (46 male and 4 female) were recruited in this study. Thirty-three of the subjects (31 male and 2 female) were reevaluated after discharge. Venous blood samples were taken …

Typing Of Chronic Obstructive Pulmonary Disease Using High-Resolution Computedtomography And The Association With Smoking, Airway Inflammation, And Commoncomorbidities, Zheng Liu, Yan Wang, Ying Liu, Mengmiao Pei, Jing Li, Fang Shi, Peixiu Li

Turkish Journal of Medical Sciences

Background/aim: This study performed typing of chronic obstructive pulmonary disease (COPD) using high-resolution computed tomography (HRCT) to determine the association with smoking, matrix metalloproteinases, and common comorbidities. Materials and methods: The study enrolled 94 hospitalized patients. Participants were divided into a group of 69 current and former smokers (group A) and a group of 25 that had never smoked (group B). Patients were also divided into 3 categories according to the degree of emphysema and bronchial wall thickness using HRCT to determine the association with levels of matrix metalloproteinase 9 (MMP-9) and TIMP-1, as well as associated comorbidities. These three …

Airway Inflammation And Tiotropium Treatment In Stable Copd Patients, Duygu Özol, Harun Karamanli, Sema Uysal, Muhammet Ramazan Yi̇ği̇toğlu, Zeki̇ Yildirim

Turkish Journal of Medical Sciences

Chronic obstructive pulmonary disease (COPD) is an inflammatory disease of the lung associated with progressive airflow limitation. The aim of this study is to assess the influence of tiotropium treatment on airway inflammation and symptoms in stable COPD patients. Materials and methods: Inflammatory markers were measured in the expired breath condensate fluid (EBC) before starting tiotropium treatment and at the end of the first month. Results: Twenty-two patients (81% men) with a mean age of 65.4 ± 10.1 years completed the study. The mean nitrotyrosine and 8-isoprostane levels for oxidative stress markers in EBC before and after treatment were 4.5 …

Contribution Of Spirometry To Early Diagnosis Of Chronic Obstructive Pulmonary Disease In Primary Health Care Centers, Aysel Erdoğan, Eli̇f Yilmazel Uçar, Ömer Araz, Leyla Sağlam, Ni̇hal Arzu Mi̇ri̇ci̇

Turkish Journal of Medical Sciences

Chronic obstructive pulmonary disease (COPD) is a common disease with increasing prevalence and mortality. We aimed to determine COPD prevalence in primary health care centers. Materials and methods: Pulmonary function tests (PFTs) and face-to-face interviews were administered to 500 patients older than 40 years of age and attending a primary health care center with any symptoms. An early reversibility test was performed on patients with a forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) ratio below 70%. The survey results, PFTs, and early reversibility test results were evaluated according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) …

Nutritional Assessment Via Anthropometric And Biochemical Measurements With Stable Copd, Mehmet Meral, Ömer Araz, Eli̇f Yilmazel Uçar, Nusret Yilmaz, Ni̇hal Arzu Mi̇ri̇ci̇

Turkish Journal of Medical Sciences

Nutritional assessment is important for the management of chronic obstructive pulmonary disease (COPD). This study aims at investigating the relation between the anthropometric and biochemical parameters for nutritional assessment with pulmonary function tests in COPD. Materials and methods: This is a prospective, cross-sectional study. Thirty-nine patients with stable COPD were enrolled the study. We evaluated the anthropometric [body mass index (BMI), skinfold thickness (SFT), and arm muscle circumference (AMC)], biochemical [serum total protein, albumin, transferrin, and blood urea nitrogen (BUN)], and spirometric [forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), and FEV1/FVC] measurements, as well as …

Effect Of Passive Smoking On The Development Of Chronic Obstructive Pulmonary Disease In Southeastern Turkey, Teki̇n Yildiz, Füsun Topçu, Yusuf Çeli̇k, Levent Akyildiz, Güngör Ateş, Di̇lek Durak

Turkish Journal of Medical Sciences

To determine the effect of passive smoking on the development of chronic obstructive pulmonary disease (COPD) among persons who spend a long time in cafes. Materials and methods: The study sample included 348 male smokers who were older than 40 years and spend a long time in cafes. The questions were derived from the European Coal and Steel Community (ECSC) questionnaire. We also inquired about the nature of cafe visits (hours/day, visits/week, visits/month). Results: COPD was found in 18.1% (63/348 subjects) of the smokers aged >=40 years. In these 63 subjects, based on spirometry results, the rate of mild and …

The Importance Of Serum Procalcitonin Levels In Patients With Chronic Obstructive Pulmonary Disease Exacerbations, Cantürk Taşçi, Arzu Balkan, Nuri̇ Karadurmuş, Satilmiş İnal, Seli̇m Kiliç, Meti̇n Özkan, Hayati̇ Bi̇lgi̇ç, Kudret Eki̇z

Turkish Journal of Medical Sciences

Aim: Chronic obstructive pulmonary disease (COPD) is a preventable and treatable, but progressive disease and hospital admissions of patients with COPD are frequently due to acute exacerbations. Acute phase reactants are capable of demonstrating the inflammation; however, they cannot be employed to make a difference between bacterial and nonbacterial causes of the inflammation. Recently, measurement of procalcitonin (PCT) levels appears to be useful in order to minimize this problem. The aim of this study was to examine whether the treatment arrangements based on serum PCT levels in patients presenting with COPD acute exacerbations will be appropriate or not. Materials and …