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Articles 1 - 30 of 102
Full-Text Articles in Medicine and Health Sciences
Review Of "The Human Embryonic Stem Cell Debate: Science, Ethics, And Public Policy (Basic Bioethics)," Edited By Suzanne Holland, Karen Lebacqz, And Laurie Zoloth, James Steele
The University of New Hampshire Law Review
[Excerpt] "Perhaps like others, I started "The Human Embryonic Stem Cell Debate" not knowing many of the finer points of embryonic stem cell research, but I certainly had an opinion. This issue is far more complex than I had initially imagined. The editors do a commendable effort of compiling a sample of the innumerable arguments surrounding the debate."
Special Article: Outline On Status Of Post-9/11 Aviation Security Initiatives, Part I, Ibpp Editor
Special Article: Outline On Status Of Post-9/11 Aviation Security Initiatives, Part I, Ibpp Editor
International Bulletin of Political Psychology
This article provides a commentary in an outline format on post-9/11 aviation security initiatives within the United States (US).
Effect Of Charge On The Deposition Of Electrostatically Charged Inhalable Aerosol In Lung Model, Divey Saini, C. U. Yurteri, N. Grable, Robert A. Sims, Malay K. Mazumder
Effect Of Charge On The Deposition Of Electrostatically Charged Inhalable Aerosol In Lung Model, Divey Saini, C. U. Yurteri, N. Grable, Robert A. Sims, Malay K. Mazumder
Journal of the Arkansas Academy of Science
Inhalable drugs are widely used for treating lung diseases such as asthma, emphysema, and cystic fibrosis. The aerosol particles in these inhalable drugs may be charged electrostatically. The deposition of these inhaled therapeutic aerosol particles in the different regions of the lung depends on the particle aerodynamic diameter, electrostatic charge distribution, particulate number density, breathing rate, aerodynamics of the lung, ambient temperature, and relative humidity (RH). The primary mechanisms for lung deposition of inhaled particles are impaction, gravitational settling, diffusion, interception, and electrostatic attraction. To simulate lung deposition, electrostatically charged aerosol particles are introduced through a throat section into a …
Synthesis And Chemistry Of Naphthalene Annulated Trienyl Iron Complexes: Potential Anticancer Dna Alkylation Reagents, Traci Means
Synthesis And Chemistry Of Naphthalene Annulated Trienyl Iron Complexes: Potential Anticancer Dna Alkylation Reagents, Traci Means
Inquiry: The University of Arkansas Undergraduate Research Journal
Iron complex chemistry that opens a new door to the medicinal and pharmaceutical worlds is the aim of this research. Specifically, ortho-quinone methide moieties are intermediates in several antitumor drugs and have been identified as bioreductive alkylators of DNA. In our research, a class of iron compounds has been targeted to resemble these quinone methides. It is hoped that these new compounds could be modified to provide a window of opportunity toward the discovery of a selective mode of drug delivery. We have focused our efforts on generating a reactive transition metal complexed 5-membered ring analog of o-quinone methide based …
Comparison Of Antibiotic Resistance Patterns Of Uropathogenic Escherichia Coli In Outpatient And Inpatient Populations From 1990 To 1996 In Bemidji, Mn, Gail R. Conway, Patrick Guilfoile
Comparison Of Antibiotic Resistance Patterns Of Uropathogenic Escherichia Coli In Outpatient And Inpatient Populations From 1990 To 1996 In Bemidji, Mn, Gail R. Conway, Patrick Guilfoile
Journal of the Minnesota Academy of Science
A retrospective study of antibiotic susceptibility was conducted on data from all uropathogenic Escherichia coli submitted to the MeritCare Clinic-Bemidji, MN and the North Country Regional Hospital-Bemidji, MN during 1990, 1993, and 1996. The proportion of antibiotic resistant strains was generally equal or higher in E. coli isolates from community-acquired infections than with E. coli isolates from nosocomial infections. Comparison with antibiotic prescriptions during 1990, 1993, and 1996 provided no clear relation between antibiotics prescribed for outpatient urinary tract infections and the proportion of E. coli strains resistant to those antibiotics. This suggests that factors other than selection for resistance …
Nitric Oxide Ii: Therapeutic Uses And Clinical Applications, Ayşe Baysal
Nitric Oxide Ii: Therapeutic Uses And Clinical Applications, Ayşe Baysal
Turkish Journal of Medical Sciences
Nitric oxide is a biological mediator in human organisms which plays important roles in tissue and organ hemostasis. Recent advances in the therapeutic uses of inhaled nitric oxide in lung diseases and other pathologic states urges the efficient and appropriate use of nitric oxide in hospitals. This study is a literature search based on a keyword search and the abstracts in English in Medline. The therapeutic indications for inhaled nitric oxide and various clinical applications are summarized. Subsequently, adverse effects and toxicity for inhaled nitric oxide and contraindications for its use are discussed.
Investigation Of The Antiviral Effect Of Vepesid On Hsv Type 2, Adi̇l M. Allahverdi̇yev, Ni̇zami̇ Duran, Öznur Uyanik
Investigation Of The Antiviral Effect Of Vepesid On Hsv Type 2, Adi̇l M. Allahverdi̇yev, Ni̇zami̇ Duran, Öznur Uyanik
Turkish Journal of Medical Sciences
Objective: Vepesid is a semisynthetic derivative of phodophylotoxin extracted from Phodophylum peltatum, which is in the group of plant alkaloids. In this study, the antiviral effect of Vepesid against herpes simplex virus type 2 (HSV-2) in in vitro conditions was investigated. Materials and Methods: In this investigation, a HEp-2 continuous cell line that was derived from human larynx cancer cells was used. The experiments were done in culture plates with smooth bases consisting of 96 wells. Cultivation of cells was realized in EMEM medium with 10% fetal bovine serum at an atmosphere of 37°C with 5% CO_2. The toxicity of …
Bacteriological Effects Of Xylitol And Different Carbohydrate Containing Diets In Swiss Albino Rats Inoculated With Streptococcus Mutans Ccug 6519, Fahi̇nur Ertuğrul, Rengi̇n Eltem, Bora A. Ataman
Bacteriological Effects Of Xylitol And Different Carbohydrate Containing Diets In Swiss Albino Rats Inoculated With Streptococcus Mutans Ccug 6519, Fahi̇nur Ertuğrul, Rengi̇n Eltem, Bora A. Ataman
Turkish Journal of Medical Sciences
The aim of the study was to investigate the bacteriological effects of different diets by Streptococcus mutans counts on 50 Swiss albino rats inoculated with Streptococcus mutans CCUG 6519 serotype c. A powdered form of standard basal diet meeting rats' nutritional needs was used in combination with diets containing different percentages of starch, sucrose and xylitol for 90 days. Dental plaque samples were collected at the end of the experiment and S. mutans and total bacterial counts were determined. S. mutans and total bacterial counts in plaque samples were the highest in the sucrose group and the differences were statistically …
Does Malnutrition During The Lactation Period Affect The Growth Of Bones And Teeth? -A Morphometric Study In Rats, Taner Zi̇ylan, Khalil Awadh Murshed, Aynur Emi̇ne Çi̇çekci̇başi
Does Malnutrition During The Lactation Period Affect The Growth Of Bones And Teeth? -A Morphometric Study In Rats, Taner Zi̇ylan, Khalil Awadh Murshed, Aynur Emi̇ne Çi̇çekci̇başi
Turkish Journal of Medical Sciences
To evaluate the effect of protein-energy malnutrition (PEM) on the growth of the mandible and incisor teeth as well as to know if the malnutrition produces modifications in the time of the eruption of the teeth in malnourished rats during the lactation period, animals were divided into experimental and control groups. Experimental pups fed by one mother's milk were doubled in their number to be twice to those of the control pups fed by one mother's milk (Park method). The animals were sacrificed at 20 and 40 days of age, and the body and total lengths of the mandible, and …
An Alternative Method To The Volume Estimation Of Cavities With Irregular Surface In The Cadaver: Measuring Right Cardiac Ventricle Of The Fetus By Using Mercury, Zeli̇ha Kurtoğlu, M. Haluk Uluutku
An Alternative Method To The Volume Estimation Of Cavities With Irregular Surface In The Cadaver: Measuring Right Cardiac Ventricle Of The Fetus By Using Mercury, Zeli̇ha Kurtoğlu, M. Haluk Uluutku
Turkish Journal of Medical Sciences
To find the volume of irregular cavities in cadavers, many researchers have used different methods including filling with any fluid and calculating the volume by usingcomplex geometrical formulas. All of these have some difficulties and disadvantages. In this paper, filling cavities with mercury is presented as an alternative method for volume estimation of the cavities. The volumes of 22 right cardiac ventricles were found by using mercury in 27-34 week-old fetuses. The method was proposed as an easy and sensitive method for volume estimation and comparison of the cavities in the cadaver.
Invasive Pulmonary Aspergillosis In Solid-Organ Transplant Recipients: Postmortem Histopathologic Findings, Banu Bi̇lezi̇kçi̇, Beyhan Demi̇rhan, Asuman Ni̇han Haberal, Ünser Arikan
Invasive Pulmonary Aspergillosis In Solid-Organ Transplant Recipients: Postmortem Histopathologic Findings, Banu Bi̇lezi̇kçi̇, Beyhan Demi̇rhan, Asuman Ni̇han Haberal, Ünser Arikan
Turkish Journal of Medical Sciences
Invasive aspergillosis is often lethal in transplant recipients. The mortality associated with this disease after organ transplantation approaches 100%, partly because it is difficult to recognize and diagnose early on. The clinical course and histological findings in invasive pulmonary aspergillosis in immunocompromised hosts differ from those seen in patients who develop classic aspergillomas. In immunosuppressed patients, the predominant pathologic abnormalities are tissue invasion, abscess formation, and angioinvasion with or without infarction. In this study, we examined cases of invasive pulmonary aspergillosis in one kidney recipient and three liver transplant recipients. All the patients were male, and their mean age was …
Nosocomial Fungal Infections In A Teaching Hospital In Turkey: Identification Of The Pathogens And Their Antifungal Susceptibility Patterns, Duygu Findik, İnci̇ Tuncer
Nosocomial Fungal Infections In A Teaching Hospital In Turkey: Identification Of The Pathogens And Their Antifungal Susceptibility Patterns, Duygu Findik, İnci̇ Tuncer
Turkish Journal of Medical Sciences
From January 1999 through April 2000, 208 Candida strains were obtained from hospitalized patients with nosocomial infection. Most of the species were isolated from urine (77.8%) followed by oropharynx (8.2%), blood stream (6.1%), drain (6.1%), peritoneum (0.9%) and cerebrospinal fluid specimens (0.9%). The distribution of the species obtained was Candida albicans (75.4%), C. glabrata (8.2%), C. tropicalis (4.8%), C. kefyr (3.4%), C. parapsilosis (2.5%), C. lusitaniae (1.9%), C. famata (1.4%), C. krusei (1.4%), and C. guilliermondii (1%). The antifungal susceptibility of the isolates to 5-fluorocytosine (5FCU), amphotericin B (AMP), nystatin (NYS), econazole (ECO), miconazole (MIC) and ketoconazole (KET) was tested …
A Survey Of Patients With Acute Poisoning In The Sivas Region, Turkey, Between 1994 And 1998, Hakan Alagözlü, Hafi̇ze Sezer, Ferhan Candan, Ertan Tabak, Nazi̇f Elaldi
A Survey Of Patients With Acute Poisoning In The Sivas Region, Turkey, Between 1994 And 1998, Hakan Alagözlü, Hafi̇ze Sezer, Ferhan Candan, Ertan Tabak, Nazi̇f Elaldi
Turkish Journal of Medical Sciences
This study was carried out over the period 1994-1998 for the purpose of observing the poisoning incidence and of presenting a poisoning profile of the Sivas region, Turkey. During the study period, 1521 patients were admitted to hospitals with various poisonings in Sivas and these were retrospectively analyzed. The results were evaluated by a chi-square test. In 1521 (1054 females, 467 males) poisoning cases, the mean annual incidence of poisonings was found to be 0.048%. When poisoning cases were assessed etiologically, drug poisonings rated first (54.8%). The most commonly ingested drugs were antidepressants (39%), analgesic-antiinflammatories (31%), antihypertensives (7%) and miscellaneous …
Factors Affecting Bone Health In Children: A Preliminary Study In Kocaeli, Gülcan Türker, Kadi̇r Babaoğlu, Demet Gedi̇kbaşi, Hakan Demi̇r, Fatma Berk, Meti̇n Aydoğan, Şükrü Hatun
Factors Affecting Bone Health In Children: A Preliminary Study In Kocaeli, Gülcan Türker, Kadi̇r Babaoğlu, Demet Gedi̇kbaşi, Hakan Demi̇r, Fatma Berk, Meti̇n Aydoğan, Şükrü Hatun
Turkish Journal of Medical Sciences
Unhealthy bones in childhood are likely to be reflected as osteoporosis in the future. This study was planned to assess the bone health of children in the Kocaeli region and to determine the risk factors in terms of osteopenia. A total of 46 healthy children aged 6-16 years (21 girls and 25 boys, mean age: 8.74±2.56 years) were included in the study. A questionaire was used by the physicians to determine the sunlight exposure, dressing habits, calcium content of the diet, vitamin supplementation and daily physical activity. Bone mineral density was evaluated using dual-energy X-ray absorptiometry at L_2-L_4 levels of …
Effects Of Increased Respiratory Resistance On Maximal O_2 Uptake And Anaerobic Threshold During Incremental Exercise Tests, Oğuz Özçeli̇k, Rami̇s Çolak
Effects Of Increased Respiratory Resistance On Maximal O_2 Uptake And Anaerobic Threshold During Incremental Exercise Tests, Oğuz Özçeli̇k, Rami̇s Çolak
Turkish Journal of Medical Sciences
This study was undertaken to assess whether maximal O_2 uptake (VO_2max) can be used as an index of measuring aerobic capacity under the condition of increased respiratory resistance. Seven male subjects performed two incremental exercise tests on a cycle ergometer on different days: one control (C) and one breathing through an 8 mm bore diameter respiratory resistance (R). Ventilatory and gas exchange responses were measured with a turbine volume transducer and mass spectrometry, and processed breath-by-breath. VO_2max was measured and anaerobic threshold (AT) was estimated non-invasively using the V-slope method. Maximal exercise performance was reduced significantly (by paired t-test, P
Serum Total Homocysteine And Premature Coronary Heart Disease: Prospective Study In Middle Aged Patients, Abdi̇ Bozkurt, Yüksel Gökel, Mesut Demi̇r, Ayhan Usal, Sali̇h Çeti̇ner
Serum Total Homocysteine And Premature Coronary Heart Disease: Prospective Study In Middle Aged Patients, Abdi̇ Bozkurt, Yüksel Gökel, Mesut Demi̇r, Ayhan Usal, Sali̇h Çeti̇ner
Turkish Journal of Medical Sciences
Homocysteine was found to be an independent risk factor for coronary artery disease in many epidemiological studies. The aim of the present study was to examine the relationship between total homocysteine levels and premature coronary artery disease events. A case - control study was carried out in patients aged 35 to 50 years with angiographically shown coronary heart disease and in age and sex matched control subjects with normal coronary angiography. Samples from 38 patients with coronary heart disease, and their paired controls were analyzed for homocysteine. Plasma homocysteine was measured by high performance liquid chromatography. Mean serum total homocysteine …
Comparison Of The Effects Of Three Forms Of Individualized Education On Asthma Knowledge In Asthmatic Patients, Rezan Demi̇ralay
Comparison Of The Effects Of Three Forms Of Individualized Education On Asthma Knowledge In Asthmatic Patients, Rezan Demi̇ralay
Turkish Journal of Medical Sciences
This study was carried out to compare the effects of three forms of individualized education (verbal, written, and verbal-written) on asthma knowledge in asthmatic patients. For this purpose, a randomized double blind controlled study was conducted with 62 adults with asthma followed-up at the outpatient clinic of Chest Diseases and Tuberculosis of the Faculty of Medicine of Suleyman Demirel University. Patients were randomized to the verbal (n:20), written (n:20), and verbal-written (n:22) education groups. Knowledge of asthma was measured at the baseline and 2 months after education. Before education, knowledge of asthma was low in the three education groups. The …
The Effects Of Three Neurosurgical Anaesthetic Methods On Hla-Dr Expression, Nusa Tuna, Meti̇n Tuna, Demet Koca, Şebnem Atici, Aniş Ariboğan
The Effects Of Three Neurosurgical Anaesthetic Methods On Hla-Dr Expression, Nusa Tuna, Meti̇n Tuna, Demet Koca, Şebnem Atici, Aniş Ariboğan
Turkish Journal of Medical Sciences
Expression of human leukocyte antigen-DR (HLA-DR) is considered a meaningful indicator of immune response because of the important role that HLA-DR plays in presenting antigen to T-lymphocytes. The aim of this study was to evaluate the effects of three anaesthetic methods (intravenous anaesthesia with propofol-fentanyl and balanced anaesthesia with isoflurane-fentanyl or sevoflurane-fentanyl) on monocytic HLA-DR expression in neurosurgical patients who underwent craniotomy. Thirty patients were divided into 3 groups of 10, and each group was the subject of one of the anaesthetic regimes noted above during craniotomy procedures. Blood samples were collected and HLA-DR expression was measured by flow cytometry …
A Rare Case Of Neonatal Hypotonia: Neonatal Nonketotic Hyperglycinemia, Ayhan Taşteki̇n, Rahmi̇ Örs, Behzat Özkan, Orhan Deni̇z
A Rare Case Of Neonatal Hypotonia: Neonatal Nonketotic Hyperglycinemia, Ayhan Taşteki̇n, Rahmi̇ Örs, Behzat Özkan, Orhan Deni̇z
Turkish Journal of Medical Sciences
Hypotonia is a serious physical finding in a newborn infant. Nonketotic hyperglycinemia (NKH) is a rare cause of neonatal hypotonia. It is a defect of the glycine metabolism and has poor prognosis. We report a case of a newborn infant with NKH, presented with mild hypotonia and high creatine kinase values. NKH should be considered in a hypotonic newborn, especially if associated with acute deterioration, lethargy and seizures.
Congenital Pseudoarthrosis Of The Clavicle With Multiple Vertebral Anomalies, Ahmet Yi̇ği̇t Göktay, Mustafa Seçi̇l, Erki̇n Çeti̇nkol, Di̇nç Özaksoy
Congenital Pseudoarthrosis Of The Clavicle With Multiple Vertebral Anomalies, Ahmet Yi̇ği̇t Göktay, Mustafa Seçi̇l, Erki̇n Çeti̇nkol, Di̇nç Özaksoy
Turkish Journal of Medical Sciences
ğit GÖKTAY Mustafa SEÇİL Erkin ÇETİNKOL Dinç ÖZAKSOY Department of Radiology, Faculty of Medicine, Dokuz Eylül University, İzmir - TURKEY
Psoas Abscess Secondary To Brucellar Spondylitis, Bi̇lgehan Aygen, Duygu Eşel, Nuri̇ Erdoğan, Orhan Yildiz, Bülent Sümerkan, Mehmet Doğanay
Psoas Abscess Secondary To Brucellar Spondylitis, Bi̇lgehan Aygen, Duygu Eşel, Nuri̇ Erdoğan, Orhan Yildiz, Bülent Sümerkan, Mehmet Doğanay
Turkish Journal of Medical Sciences
No abstract provided.
Production And Purification Of Monoclonal Antibodies To Human Interleukin-2 And Their Use For Immunoaffinity Purification Of Recombinant Human Interleukin-2, Cemaletti̇n Aybay
Production And Purification Of Monoclonal Antibodies To Human Interleukin-2 And Their Use For Immunoaffinity Purification Of Recombinant Human Interleukin-2, Cemaletti̇n Aybay
Turkish Journal of Medical Sciences
Monoclonal antibodies (mAbs) are a powerful immunochemical tool. Today, the availability of mAbs with desired specificity enables ligand separation based upon the immunoaffinity technique. By using the high selectivity of mAbs, immunoaffinity purification offers the possibility of isolating compounds even from complex samples with a selectivity which cannot be achieved by other methods. This paper reports the preparation and identification of monoclonal antibodies against human interleukin-2 (IL-2) and the establishment of an immunoaffinity method for purifying human IL-2 (hIL-2). Hybridomas were generated by the fusion of NSO or FO myelomas and spleen cells from immunized mice. Hypoxanthine-aminopterin-thymidine-resistant hybridomas secreting antibodies …
The Relation Between Low-Density Lipoprotein (Ldl) Oxidation And Hemodialysis With Respect To Membrane Types Protective Effects Of Vitamin E-Bonded Membrane, Selda Demi̇rtaş, Gökhan Nergi̇soğlu, Ayşegül Akbay Yarpuzlu, Levent Karaca
The Relation Between Low-Density Lipoprotein (Ldl) Oxidation And Hemodialysis With Respect To Membrane Types Protective Effects Of Vitamin E-Bonded Membrane, Selda Demi̇rtaş, Gökhan Nergi̇soğlu, Ayşegül Akbay Yarpuzlu, Levent Karaca
Turkish Journal of Medical Sciences
Plasma total antioxidant (TAO) levels, LDL (low density lipoprotein), antioxidant defense potential (AOP) and the resistance to oxidation of LDL fractions were studied in chronic hemodialysis patients. The differences with respect to dialyzer membrane types before and after hemodialysis were also assessed. After isolation of LDL from plasma by precipitation, AOP was measured based on the determination of TBARS (thiobarbituric acid reactive substance), and resistance to oxidation was assessed by the metal-catalyzed peroxidation of LDL followed by the determination of the values of the peroxidation product malondialdehide (MDA) before and after peroxidation. The assay principle of TAO was based on …
Effect Of Low Dietary Zinc Intake And Experimental Diabetes On The Zinc And Carbohydrate Metabolism In Rats, Zine Kechrid, Nazan Demi̇r, Cherif Abdennour, Noureddine Bouzerna
Effect Of Low Dietary Zinc Intake And Experimental Diabetes On The Zinc And Carbohydrate Metabolism In Rats, Zine Kechrid, Nazan Demi̇r, Cherif Abdennour, Noureddine Bouzerna
Turkish Journal of Medical Sciences
To investigate the effect of low dietary zinc intake and experimental diabetes (IDDM) on the zinc and carbohydrate metabolism, 8-week-old male wealing normal albino (Wistar) rats were fed diets containing either adequate (54mg/kg) or low zinc (1mg/kg) quantities for one week. Ten rats from each group (n=20) were then intraperitoneally injected with alloxan to induce diabetes. The rats were sacrificed after a further three weeks. Body weight gain and food intake were recorded regularly. On day 28, after an overnight fast, the animals were sacrificed and blood glucose, serum insulin, serum cholesterol concentrations, liver glycogen contents, and femur and pancreatic …
Cholesterol Has An Inflammatory Influence In The Effects Of Fats On Metabolism In Endotoxemic Rats, Hali̇t Tanju Besler, Robert Francis Grimble
Cholesterol Has An Inflammatory Influence In The Effects Of Fats On Metabolism In Endotoxemic Rats, Hali̇t Tanju Besler, Robert Francis Grimble
Turkish Journal of Medical Sciences
We showed that butter suppresses metabolic responses to endotoxin in Wistar rats. Responses included increases in plasma caeruloplasmin and liver zinc and protein concentrations, and decreases in plasma zinc and albumin concentration. However, butter lost its suppressive effect at dietary concentrations above 90g/kg diet. The present study examined whether this phenomenon was due to the total dietary cholesterol intake rather than the intrinsic fatty acid composition of butter. Rats received diets, for four weeks, containing either 100g/kg corn oil, 90 g/kg butter, 190g/kg butter, or 90 g/kg butter supplemented with cholesterol to render the latter two diets identical in cholesterol …
Microscopy Of Rat Thoracic Aorta In Chronic Ethanol Intake, Feral Öztürk, Ni̇gar Vardi, Nureddi̇n Cengi̇z, Mukaddes Eşrefoğlu, Ali̇ Otlu
Microscopy Of Rat Thoracic Aorta In Chronic Ethanol Intake, Feral Öztürk, Ni̇gar Vardi, Nureddi̇n Cengi̇z, Mukaddes Eşrefoğlu, Ali̇ Otlu
Turkish Journal of Medical Sciences
The aim of this study was to determine the histological changes of the thoracic aorta in rats fed on alcohol for a period of 24 weeks. Twenty male Wistar rats were divided into two groups. The ethanol group (n=10) was fed on a modified liquid diet (MLD) containing 7.2% ethanol for 24 weeks. The control group (n=10) was fed on MLD without ethanol throughout the experiment. At the end of the 24 weeks, the carotid arteries of the rats were cannulated and their blood pressures were measured. Ethanol levels measured by using the NAD+/NADH enzyme-spectrophotometric method. Rats were killed by …
Discrimination Between The Acidic And Molecular Effects Of Lactate On Muscle Tension Development, Şeref Erdoğan, Sanli Sadi̇ Kurdak, Ni̇lay Ergen, Ayşe Doğan
Discrimination Between The Acidic And Molecular Effects Of Lactate On Muscle Tension Development, Şeref Erdoğan, Sanli Sadi̇ Kurdak, Ni̇lay Ergen, Ayşe Doğan
Turkish Journal of Medical Sciences
Fatigue can be defined as the decrease in the genesis of maximal muscle tension, and it may develop when metabolic end-products cannot be readily washed out. During anaerobic exercises, lactate accumulates in the muscle and blood, resulting in acidic pH in these tissues. Fatigue during lactate accumulation is generally attributed to its acidifying property; however, the inverse effect of lactate on muscle tension also at isopH values may be due to the molecular as well as the acidifying effects of this metabolite. In this study, we aimed to distinguish the molecular and acidifying effects of high lactate, both of which …
Antitumor Effects Of Tnf-\Beta, 5-Fu And Their Combinations On Cervical Carcinoma Cell Lines, Hakan Akça, Osman Ni̇dai̇ Özeş
Antitumor Effects Of Tnf-\Beta, 5-Fu And Their Combinations On Cervical Carcinoma Cell Lines, Hakan Akça, Osman Ni̇dai̇ Özeş
Turkish Journal of Medical Sciences
Cervical carcinoma is one type of cancer with a high mortality rate in females. In this study, we investigated the cytotoxic effects of TNF-\beta, 5-FU and their combinations on human cervical carcinoma cell lines, ME180 and HeLa. The highest degree of cytotoxic effect was obtained with 5-FU on both cell lines. While high concentrations of TNF-\beta showed cytotoxic effects on both cell lines, the lowest dose induced growth. Combination treatment of 5-FU and TNF-\beta gave a slightly higher cytotoxic and antiproliferative response compared to individual use of 5-FU and TNF-\beta on both cell lines.
The Dosimetric Verification Of Commercial Two- And Three- Dimensional Radiation Treatment Planning Systems, Ayhan Kiliç, Lütfi̇ Özkan, Kayihan Engi̇n
The Dosimetric Verification Of Commercial Two- And Three- Dimensional Radiation Treatment Planning Systems, Ayhan Kiliç, Lütfi̇ Özkan, Kayihan Engi̇n
Turkish Journal of Medical Sciences
For the quality assurance (QA) of radiation treatment planning systems (RTPSs) and planning computed tomography (CT), a simple cylindrical phantom was developed. The phantom was constructed by using materials and geometries appropriate for the routine clinic setups. A Siemens Somatom HiQ CT, two-dimensional (2D) and three-dimensional (3D) RTPS and a linear accelerator Siemens Mevatron MD2 were used in this study. The 2D and 3D RTPSs gave good results when compared to actual doses measured in the phantom. While the 3D system showed accuracy similar (-1.0% vs. -0.8%) to that of the 2D system for 6 MV and better accuracy (+1.4% …
Thymidine Labeling Index In Laryngeal Squamous Cell Carcinoma, Murat Ünal, Ayhan Bi̇li̇r, Mesut Can Karatay, İsmai̇l Çölhan
Thymidine Labeling Index In Laryngeal Squamous Cell Carcinoma, Murat Ünal, Ayhan Bi̇li̇r, Mesut Can Karatay, İsmai̇l Çölhan
Turkish Journal of Medical Sciences
The aim of this study was to investigate the prognostic value of the thymidine labeling index (TLI) in laryngeal squamous cell carcinoma (SCC). The TLI in tumor tissue and adjacent healthy tissue was assessed prospectively in 31 patients and these values were correlated with age, TNM, grade and recurrence statistically. The tissues (tumoral and adjacent tumor-free tissue) that were obtained during surgery were labeled with ^3H-Thymidine. TLI was calculated as the number of labeled tumor cells * 100 / total number of tumor cells. A statistically significant difference was observed between tumor tissue (mean TLI value = 17.62± 6.39%) and …