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Articles 1 - 30 of 115
Full-Text Articles in Medicine and Health Sciences
Jeffress Research Grant Awards
Jeffress Research Grant Awards
Virginia Journal of Science
Announcements of the Jeffress Research Grants that have been awarded in 1999.
Obesity And The Activity Of The Autonomicnervous System, Rami̇s Çolak, Emi̇r Dönder, Azi̇z Karaoğlu, Oğuz Ayhan, Mehmet Yalniz
Obesity And The Activity Of The Autonomicnervous System, Rami̇s Çolak, Emi̇r Dönder, Azi̇z Karaoğlu, Oğuz Ayhan, Mehmet Yalniz
Turkish Journal of Medical Sciences
This study was conducted to examine the autonomic nervous system functions of obese people. The study group consisted of 30 healthy obese people (20 female, 10 male, age range 18-58, median 37.6±9.7 years of age) and the control group consisted of 30 healthy nonobese people (18 female, 12 male, age range 17- 56, median 34.4±7.5 years). Each function was tested by non-invasive applications (orthostatic test, isometric exercise test, Valsalva ratio test, 30/15 ratio test, heart rate change test by deep respiration). The results of the orthostatic test and isometric- exercise test yielded a statistically significant difference between the study and …
Determining Functional Hand Capacity In Textileworkers In Different Departments, Hani̇fegül Taşkiran, Ali̇ Ki̇ti̇ş, Hülya Akdur
Determining Functional Hand Capacity In Textileworkers In Different Departments, Hani̇fegül Taşkiran, Ali̇ Ki̇ti̇ş, Hülya Akdur
Turkish Journal of Medical Sciences
The aim of this study, which was carried out in the Textile Department of the Denizli Printing and Dyeing Industry Inc., was to compare ergonomic work analysis findings in which the functional hand capacity of workers and working conditions were evaluated. A total of 225 textile workers (143 women and 82 men) were included in our study. The working conditions were evaluated by ergonomic work analysis. The functional hand capacities of the workers were evaluated by the Valpar Upper Extremity Range of Motion Test and the Purdue Pegboard Test. The results that were obtained were interpreted by the statistical methods …
Prevalence Of Diabetes Mellitus And Affectedfactors In The District Of Kayseri Health Grouparea, Yusuf Öztürk, Mualla Aykut, Fahretti̇n Keleşti̇mur, Osman Günay, Fevzi̇ye Çeti̇nkaya, Osman Ceyhan, Mücahi̇t Eğri̇
Prevalence Of Diabetes Mellitus And Affectedfactors In The District Of Kayseri Health Grouparea, Yusuf Öztürk, Mualla Aykut, Fahretti̇n Keleşti̇mur, Osman Günay, Fevzi̇ye Çeti̇nkaya, Osman Ceyhan, Mücahi̇t Eğri̇
Turkish Journal of Medical Sciences
The aim of this study was to determine the prevalence of diabetes mellitus and associated risk factors in rural Kayseri in Central Anatolia and to demonstrate whether glucometers can be used in epidemiological studies. This research was performed in Kayseri in 1994. The research population consisted of 3713 people chosen randomly among men and women of 30 years of age and over. The prevalence of diabetes mellitus was identified as 5.6 %. In addition, the prevalence of diabetes mellitus was found to be higher in men than in women, in people of 50 and over than in people of 49 …
Sonographic Evaluation Of Liver And Spleen Sizein School-Age Children, Kaya Saraç, Ramazan Kutlu, Cengi̇z Yakinci, Yaşar Durmaz, Tamer Baysal, Ünsal Özgen
Sonographic Evaluation Of Liver And Spleen Sizein School-Age Children, Kaya Saraç, Ramazan Kutlu, Cengi̇z Yakinci, Yaşar Durmaz, Tamer Baysal, Ünsal Özgen
Turkish Journal of Medical Sciences
The purpose of this study was to determine normal liver and spleen size variations in school-age children by US. Sonographic measurements were taken with an age and sex stratified random sample of 358 healthy children (188 boys, 170 girls) between the ages of 7 and 12 years. The weight and height of the children were assessed and then the body surface area (BSA) of each child was calculated. The size of the liver was measured in two different planes: the subcostal sagittal (L1), and subcostal semiaxial (L2). Spleen size was measured through a coronal view that included the hilum (S1) …
Isoniazid Poisoning With Seizures, Shoulderdislocation, And Fracture Of The Greatertuberosity, Yüksel Gökel, Sali̇m Satar, Mehmet Duru, Zi̇kret Köseoğlu, Güven Kuvandik
Isoniazid Poisoning With Seizures, Shoulderdislocation, And Fracture Of The Greatertuberosity, Yüksel Gökel, Sali̇m Satar, Mehmet Duru, Zi̇kret Köseoğlu, Güven Kuvandik
Turkish Journal of Medical Sciences
No abstract provided.
Acute Dynamic Exercise Reduces Intraocularpressure, İbrahi̇m Koçer, Şenol Dane
Acute Dynamic Exercise Reduces Intraocularpressure, İbrahi̇m Koçer, Şenol Dane
Turkish Journal of Medical Sciences
No abstract provided.
Mri In Joubert Syndrome, Nai̇l Bulakbaşi, Taner Üçöz, Cem Tayfun, Yüksel Pabuşçu, Alper Alemdaroğlu
Mri In Joubert Syndrome, Nai̇l Bulakbaşi, Taner Üçöz, Cem Tayfun, Yüksel Pabuşçu, Alper Alemdaroğlu
Turkish Journal of Medical Sciences
No abstract provided.
Adult Respiratory Distress Syndrome Caused By Psittacosis, Aysun Yilmazlar, Beri̇n Özcan, Nuray Kaplan, Oya Kutlay
Adult Respiratory Distress Syndrome Caused By Psittacosis, Aysun Yilmazlar, Beri̇n Özcan, Nuray Kaplan, Oya Kutlay
Turkish Journal of Medical Sciences
No abstract provided.
The Effects Of Sodium Selenite On The Antioxidative Defence Mechanism Of Human Hepatoma G_2 Cells, Kayahan Fişkin
The Effects Of Sodium Selenite On The Antioxidative Defence Mechanism Of Human Hepatoma G_2 Cells, Kayahan Fişkin
Turkish Journal of Medical Sciences
Human cells that live in biological harmony can become cancerous. As they do so, they engage in anaerobic respiration, undergo rapid cell growth and division according to nonmitotic rules, and important changes take place in their metabolism. We conducted several investigations in an effort to block or change the metabolic characteristics of cancer cells using a typical cancerous cell line. Specifically,we investigated the effects of sodium selenite (Na_2 SeO_ 3 ) on antioxidant enzyme activities and reduced glutathione levels in Hepatoma G_ 2 cells, cells that show rapid glutamine uptake and metabolism. A Hepatoma G_ 2 cell line was cultured …
Effects Of Growth Hormone On Bacterial Translocation Due To Intestinal Obstruction, Ahmet A. Balik, M. İlhan Yildirgan, Ali̇ Kiliç, Cemal Gündoğdu, Fazli Erdoğan
Effects Of Growth Hormone On Bacterial Translocation Due To Intestinal Obstruction, Ahmet A. Balik, M. İlhan Yildirgan, Ali̇ Kiliç, Cemal Gündoğdu, Fazli Erdoğan
Turkish Journal of Medical Sciences
Bacterial translocation is an important etiologic factor in multisystem organ failure and sepsis, which have a high mortality rate. To determine the effects of growth hormone on bacterial translocation, an experimental study was performed. Twenty pathogen-free rabbits were divided into two groups each containing 10 rabbits. After loop obstruction was performed, the rabbits in the control group were given saline solution whereas the rabbits in the study group received growth hormone. Relaparotomy was performed after 24 hours, and tissue and blood samples were collected for histopathologic and microbiologic examinations. Bacterial translocation rates were higher in the control group than in …
Nimodipine Aggravates Systemic Kainic Acid Toxicity In Retinal Ganglion Cells Of Intact Mice, Akçahan Gepdi̇remen, Murat Kaya, İbrahi̇m Koçer, Cemal Gündoğdu
Nimodipine Aggravates Systemic Kainic Acid Toxicity In Retinal Ganglion Cells Of Intact Mice, Akçahan Gepdi̇remen, Murat Kaya, İbrahi̇m Koçer, Cemal Gündoğdu
Turkish Journal of Medical Sciences
The aim of the present study was to investigate the role of the L-type voltage dependent Ca^2^+ channel blocker, nimodipine, in kainate induced toxicity in retinal ganglion cells of mice. Kainate in 10mg/kg was administered intraperitoneally following the vehicle or nimodipine. Nimodipine, 45 minutes prior to kainate in 10, 15, 25, 50, 100 and 250 mg/kg doses was administered intraperitoneally. Surprisingly, nimodipine potentiated the ganglional cell death induced by kainate, with respect to the control and kainate+vehicle treated group. In accordance with our results, blockage of L-type calcium channels by nimodipine may worsen the prognosis and survival of retinal neurons …
The Effect Of Halothane On The Enzymatic Activity Of Mouse Liver And Erythrocyte Glucose-6- Phosphate Dehydrogenase, Ergül Belge Kurutaş, Güneş T. Yüregi̇r, İlhan Tuncer
The Effect Of Halothane On The Enzymatic Activity Of Mouse Liver And Erythrocyte Glucose-6- Phosphate Dehydrogenase, Ergül Belge Kurutaş, Güneş T. Yüregi̇r, İlhan Tuncer
Turkish Journal of Medical Sciences
The effects of repeated halothane anaesthesia on 6-10 week old male, Mus musculus albino mice weighing 29-32 g were studied. Halothane, a widely used anaesthetic, is known to be metabolised in the liver to toxic intermediates through cytochrome P4502E1 (CYP2E1). During the first week of repeated dosage, glucose-6- phosphate dehydrogenase (G6PDH) activity decreased in both erythrocytes and liver cells, and during this time, livers increased significantly in weight and suffered histopathological damage, the damage increasing with the dosage of halothane, in the range 0.25-1.0 ml twice daily. When repeated anaesthesia was continued for a second week, G6PDH activity increased significantly …
Effect Of Low-Intensity Microwave Radiation On Rat Kidney: An Ultrastructural Study, Yusuf Nergi̇z, M. Aydin Ketani̇, Zülküf Akdağ, Ahmet Reşi̇t Ersay, M. Sali̇h Çeli̇k
Effect Of Low-Intensity Microwave Radiation On Rat Kidney: An Ultrastructural Study, Yusuf Nergi̇z, M. Aydin Ketani̇, Zülküf Akdağ, Ahmet Reşi̇t Ersay, M. Sali̇h Çeli̇k
Turkish Journal of Medical Sciences
Exposure to low-intensity microwave radiation for prolonged periods is known to be a potential factor inducing visceral damage. There are several studies in the literature demonstrating the harmful effects of such radiation on the kidney of laboratory animals. Our aim was to determine the effect of low intensity microwave radiation on rat kidney at the light and electron microscopic level. Animals (28 rats) in the experiment group were exposed to 2.65 mW/cm 2 radition (9450 MHz) for 1 h per day during 26 and 52 days respectively and tissue samples of these animals were examined and compared with those of …
Quantitation Of Neuronal Loss Induced By Status Epilepticus And The Effects Of Nitric Oxide, Güldal Güleç, Behzat Noyan
Quantitation Of Neuronal Loss Induced By Status Epilepticus And The Effects Of Nitric Oxide, Güldal Güleç, Behzat Noyan
Turkish Journal of Medical Sciences
Neuronal loss in the hippocampal CA1 and CA3 fields due to lithium-pilocarpine- induced status epilepticus (SE) and the effects of a nitric oxide (NO) substrate, L-Arginine and a NO synthase inhibitor, N_w -nitro-L-Arginine methyl ester (L-NAME) on SE-induced brain damage were determined using the neuron counting procedure in rats. Rats were implanted with four chronic, epidural screw electrodes in order to obtain electrocortical recordings. SE was determined from the electrocortical recordings. After decapitation, the brains were removed, and the hippocampal sections were obtained and stained with hematoxylin and eosin. An analysis of variance (ANOVA) and Student's t- test were used …
Biomimetic Preparation Of Ha Powders At 37°C In Urea-And Enzyme Urease-Containing Synthetic Body Fluids, Defne Bayraktar, A. Cüneyt Taş
Biomimetic Preparation Of Ha Powders At 37°C In Urea-And Enzyme Urease-Containing Synthetic Body Fluids, Defne Bayraktar, A. Cüneyt Taş
Turkish Journal of Medical Sciences
An important inorganic phase of synthetic bone applications, calcium hydroxyapatite (HA, Ca_10 (PO_ 4 ) 6_(OH_2 ), was prepared as a single-phase and sub-micron bioceramic powder. Carbonated HA powders were synthesized from calcium nitrate tetrahydrate and di-ammonium hydrogen phosphate salts dissolved in synthetic body fluid (SBF) solutions, containing urea (H_2 NCONH_2 ) and enzyme urease, under the biomimetic conditions of 37°C and pH 7.4, with a novel chemical precipitation technique. These powders were also found to contain trace amounts of Na and Mg ions in them, intentionally incorporated by using SBF solutions, instead of pure water, during their synthesis. The …
The Use Of A Nonradioactive Digoxigenin Labeled Probe For Detection Of Apo(A) Gene Size, Yeşi̇m İlçöl, Bülent İlçöl, Yavuz Taga
The Use Of A Nonradioactive Digoxigenin Labeled Probe For Detection Of Apo(A) Gene Size, Yeşi̇m İlçöl, Bülent İlçöl, Yavuz Taga
Turkish Journal of Medical Sciences
Elevated lipoprotein(a) [Lp(a)] concentrations are associated with premature coronary heart disease and early myocardial infarction. In the general human population the sizes of apolipoprotein [apo(a)] isoforms are inversely associated with lipoprotein(a) levels. Large isoforms are associated with low Lp (a) and small isoforms with high Lp(a) in the plasma. The size of the polymophism is directly correlated with the number of kringle-4 domains in apo(a). It has been shown by quantitative Southern blotting, and more recently by pulsed-field gel electrophoresis, that polymophism is the result of differences in the number of tandem kringle-4 repeats in the apo(a) gene. In our …
Establishment Of A Nonradioactive Molecular Diagnosis Of Fragile-X Syndrome, Zehra Oya Uyguner, Bernd Wollnik, Hülya Kayseri̇li̇, Turgut Tükel, Seher Başaran, Memnune Yüksel Apak
Establishment Of A Nonradioactive Molecular Diagnosis Of Fragile-X Syndrome, Zehra Oya Uyguner, Bernd Wollnik, Hülya Kayseri̇li̇, Turgut Tükel, Seher Başaran, Memnune Yüksel Apak
Turkish Journal of Medical Sciences
Fragile-X syndrome is a hereditary dynamic mutation disorder, predominantly caused by a large expansion of CGG trinucleotide repeats in the FMR 1 gene leading to methylation and down regulation of transcription of the gene. For the molecular diagnosis of the disease, the repeat locus in FMR 1 gene is primarily detected by Southern blotting with radioactively labeled probes. Unusually GC rich composition of the expanded region caused technical difficulties during PCR based testing and therefore is not performed by most diagnostic laboratories. We established a Southern blot method and a novel PCR protocol which enables the amplification of normal, premutated …
Assessment Of Proliferative Activity In Soft Tissue Sarcomas Showing Pcna And Ki-67 Reactivity Immunohistochemically, Özlem Aydin, Canan Ersöz, Serdar Özbarlas, Gülşah Şeydaoğlu
Assessment Of Proliferative Activity In Soft Tissue Sarcomas Showing Pcna And Ki-67 Reactivity Immunohistochemically, Özlem Aydin, Canan Ersöz, Serdar Özbarlas, Gülşah Şeydaoğlu
Turkish Journal of Medical Sciences
The aim of this study was to determine PCNA (Proliferating Cell Nuclear Antigen) and Ki-67 expression of various soft tissue sarcomas (STS) immunohisto-chemically and to correlate with the histologic grade of these tumors. Retrospectively 185 cases of STS were re-examined. Of the 185 cases, 35 primary STS cases which were localized in the extremities and trunk wall were included in this study. Anti-PCNA and Anti-Ki-67 monoclonal antibodies were applied to the paraffin sections of tumor tissues immunohistochemically. A semiquantitative score was employed to assess the percentage of cells that were positively stained. The comparison of the positively stained tumor cell …
Abnormalities Of The Midline Cavities Of The Brain: A Computerized Tomography Study, Zehra Akgün, Erdem Gümüşburun, Mustafa Akgün, H. Murat Göksel, Ferruh Yücel
Abnormalities Of The Midline Cavities Of The Brain: A Computerized Tomography Study, Zehra Akgün, Erdem Gümüşburun, Mustafa Akgün, H. Murat Göksel, Ferruh Yücel
Turkish Journal of Medical Sciences
This is a preliminary study carried out on the adult population of the Sivas region. The aim was to determine the incidence of Cavum Septum Pellucidum (CSP), Cavum Vergae (CV) and Cavum Velum Interpositi (CVI) and to compare the results with the data of previous studies and the relevant literature. A total of 442 computed tomography (CT) scans (302 males, 140 females), in axial plane, from the archive of the Department of Neurosurgery at Cumhuriyet University were examined to find out the brain midline cavities. Among the 442 CT scans, 69 (15.61%) had these brain midline cavities. Out of these …
The Role Of Immunological Factors In Wound Infections (A Prospective Clinical Study), Nusret Akyürek, Mustafa Kerek, Osman Yüksel, Türkan Patiroğlu
The Role Of Immunological Factors In Wound Infections (A Prospective Clinical Study), Nusret Akyürek, Mustafa Kerek, Osman Yüksel, Türkan Patiroğlu
Turkish Journal of Medical Sciences
Wound infections are among the major problems complicating surgical procedures. The aim of this study was to investigate the relationship between the immunological status of the patient and wound infections. Wounds were classified as clean, clean-contaminated, contaminated and dirty. T-lymphocyte(CD3+), B-lymphocyte (CD19+) and total lymphocyte(CD45+) counts, and IgG, IgM, IgA levels were measured at the beginning of treatment, and on the fifth and tenth days. The levels of CD3+, CD19+, CD45+, IgGM, IgA were not different in the groups, while in the dirty group, IgG levels were lower than in the other groups, at the beginning of treatment (P0.05). There …
Decreased Placental Adrenomedullin May Play Role In Preeclampsia, Remzi̇ Gökdeni̇z, Muhi̇tti̇n Yürekli̇, Alanur Menekşe, Nursel Bazoğlu
Decreased Placental Adrenomedullin May Play Role In Preeclampsia, Remzi̇ Gökdeni̇z, Muhi̇tti̇n Yürekli̇, Alanur Menekşe, Nursel Bazoğlu
Turkish Journal of Medical Sciences
Adrenomedullin (AdM) is a novel peptide that elicits a long-lasting vasorelaxant activity. It is expressed in several tissues, including adrenal medulla, heart, lung, kidneys, and cultured vascular smooth muscle cells. Also in large amounts, it is present in amniotic fluid and cord blood. The aim of this study was to assess placental AdM secretion in preeclampsia. Placental tissues were collected from seven preeclamptic patients and ten healthy gravidas. Tissue concentration of rat AdM was measured by using reverse-phase high performance liquid chromatography (Cecil 1100). Mann Whitney U test was used for statistical significance. Significance was set at p
Prevalence Of Goitre And Its Relationship With Iodine Deficiency In School Children In Kocaeli, Turkey, Şükrü Hatun, Sidika Beykal, Yenal Dündar, Olcay Evli̇yaoğlu
Prevalence Of Goitre And Its Relationship With Iodine Deficiency In School Children In Kocaeli, Turkey, Şükrü Hatun, Sidika Beykal, Yenal Dündar, Olcay Evli̇yaoğlu
Turkish Journal of Medical Sciences
Prevalence of Goitre and Its Relationship with Iodine Deficiency in School Children in Kocaeli, Turkey 5564 primary school children living in Kocaeli, Turkey, were clinically assessed for thyroid gland enlargement. Goitre was graded according to the WHO 1994 classification. 792 children showed various grades of goitre, giving a prevalence of overall goitre of 14.23%. The median urinary iodine values were found to be greater than 10mg/dl in each group of 20 students, who were selected randomly from those in whom Grade I and Grade II goitre had been detected and from those in whom goitre had not been detected. These …
Lymphocyte Subsets In Acute Post-Streptococcal Glomerulonephritis, Yavuz Tekeli̇oğlu, Hi̇lal Mocan, M. Zi̇ya Mocan, H. Önder Ersöz
Lymphocyte Subsets In Acute Post-Streptococcal Glomerulonephritis, Yavuz Tekeli̇oğlu, Hi̇lal Mocan, M. Zi̇ya Mocan, H. Önder Ersöz
Turkish Journal of Medical Sciences
This prospective study was designed to investigate lymphocyte subsets in acute post-streptococcal glomerulonephritis (APSGN). Peripheral blood lymphocytes were analyzed using fluorescein isothiocyanate (FITC) labeled CD3, CD4, CD8, CD14, CD19, CD45, CD56, CD45RA and CDW29 monoclonal antibodies by flow cytometry. Twenty patients aged 14-22 years who fulfilled the diagnostic criteria for APSGN were evaluated during the 1st and 12th weeks of the of disease. Twenty-four age-matched healthy subjects served as controls. At the onset of the disease, all patients had macroscopic haematuria with red blood cell casts in urine, proteinuria (1.06±0.21 g/d), low complement 3 (C3) levels (200 IU/ml), edema, oliguria …
Biodegradable Implants In Orthopaedics And Traumatology, Haluk Yetki̇n, Alpaslan Şenköylü, Erdal Ci̇la, Aki̇f Muhtar Öztürk, Sezai̇ Aykin Şi̇mşek
Biodegradable Implants In Orthopaedics And Traumatology, Haluk Yetki̇n, Alpaslan Şenköylü, Erdal Ci̇la, Aki̇f Muhtar Öztürk, Sezai̇ Aykin Şi̇mşek
Turkish Journal of Medical Sciences
Biodegradable implants are an alternative to metallic implants and have the advantage of not being necessary to remove once the fracture has healed. Twenty-two patients with fractures were treated with biodegradable implants. There were osteolysis in eleven patients; however, no serious complication was encountered. Although biodegradable implants are expensive, a second surgical procedure to remove the implants is not necessary, relieving the patient of the related costs and risks.
Klippel-Trenaunay Syndrome, Pinar Polat, Beşi̇r Erdoğmuş, Suat Eren, Selami̇ Suma, Abdul Meci̇t Kantarci
Klippel-Trenaunay Syndrome, Pinar Polat, Beşi̇r Erdoğmuş, Suat Eren, Selami̇ Suma, Abdul Meci̇t Kantarci
Turkish Journal of Medical Sciences
No abstract provided.
Congenital Chylothorax, Ni̇lgün Köksal, Sultan Demi̇r, Mehmet Okan, Cengi̇z Gebi̇teki̇n, Işik Şenkaya
Congenital Chylothorax, Ni̇lgün Köksal, Sultan Demi̇r, Mehmet Okan, Cengi̇z Gebi̇teki̇n, Işik Şenkaya
Turkish Journal of Medical Sciences
No abstract provided.
Serum Antiotensin Converting Enzyme Activity In Streptozotocin-Induced Diabetic Rats, Mustafa Vakur Bor, Esra Seval Elmali, Ni̇lgün Altan
Serum Antiotensin Converting Enzyme Activity In Streptozotocin-Induced Diabetic Rats, Mustafa Vakur Bor, Esra Seval Elmali, Ni̇lgün Altan
Turkish Journal of Medical Sciences
No abstract provided.
Telomeric Repeats Of Immortal Hamster Cells, Nedi̇me Serakinci, Jorn Koch
Telomeric Repeats Of Immortal Hamster Cells, Nedi̇me Serakinci, Jorn Koch
Turkish Journal of Medical Sciences
We have analyzed telomeres in four hamster cell lines to investigate how telomeres look in cells grown past the Hayflick limit. In all four cell lines telomeric signals were seen after detection with two different sensitive in situ methods (FISH with PNA probes and PRINS). The telomeric signals were not very strong, suggesting that the repeats are very short, but were nevertheless clearly visible. With the PRINS technique, it was further possible to probe also for the presence of variant telomeric repeats at the chromosome ends. With some of the variant repeat probes, a difference was seen between probes for …
Effects Of Angiotensin Converting Enzyme Inhibitors In Healthy Rats And In Rats With Carbon Tetrachloride-Induced Toxic Hepatitis, Ercüment Ovali, Mustafa Çeti̇ner, Si̇ret Rati̇p, Fazil Aydin, Yavuz Tekeli̇oğlu, Sami̇ Karti, Asim Örem, Gökhan Harova, Levent Albayrak, Nazim Ağaoğlu
Effects Of Angiotensin Converting Enzyme Inhibitors In Healthy Rats And In Rats With Carbon Tetrachloride-Induced Toxic Hepatitis, Ercüment Ovali, Mustafa Çeti̇ner, Si̇ret Rati̇p, Fazil Aydin, Yavuz Tekeli̇oğlu, Sami̇ Karti, Asim Örem, Gökhan Harova, Levent Albayrak, Nazim Ağaoğlu
Turkish Journal of Medical Sciences
Sulphydryl-containing captopril (CPR) appears to act as a scavanger of oxygen derived free radicals. This is not present in other angiotensin-converting enzymes such as enalapril (EPR). The hepatotoxic effect of carbon tetrachloride (CCl4) may result from induction of reactive oxygen free radicals. The aim of this study was to analyse the effects of CPR and non- sulphydryl-containing enalapril (EPR) in healthy rats and in rats with CCL4-induced toxic hepatitis. The rats were divided into two major groups. The first group consisted of healthy rats, and the second group consisted of rats with CCl4- induced toxic hepatitis. Each major group was …