Open Access. Powered by Scholars. Published by Universities.®
- Institution
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Rheological Characterization Of Blood-Mimicking Fluids For Use In Particle Image Velocimetry, Anorin S. Ali
Rheological Characterization Of Blood-Mimicking Fluids For Use In Particle Image Velocimetry, Anorin S. Ali
Undergraduate Student Research Internships Conference
Blood-mimicking fluids (BMFs) are often used to investigate blood flow using physical replicas of vessels with cardiovascular disease. Particle image velocimetry (PIV) is used with silicone poly-dimethyl siloxane (PDMS) vascular models to visualize this flow. The challenge is creating a blood-mimicking fluid that matches the viscosity profile, viscoelasticity, and density of whole blood while also matching the refractive index (RI) of PDMS. Water-glycerol solutions are commonly used with sodium iodide (NaI) added to increase the RI without changing viscosity. However, NaI is expensive, stains easily, and turns fluids from optically clear to yellow in less than a day. Furthermore, without …
Validating Hemoglobin Saturation And Dissolved Oxygen In Tumors Using The Oxylab Probe And Photoacoustic Imaging, Jenna Burnett, Justin Sick, Ms, Marc Mendonca, Keith Stantz, Phd
Validating Hemoglobin Saturation And Dissolved Oxygen In Tumors Using The Oxylab Probe And Photoacoustic Imaging, Jenna Burnett, Justin Sick, Ms, Marc Mendonca, Keith Stantz, Phd
The Summer Undergraduate Research Fellowship (SURF) Symposium
The goal of this experiment is to validate the relationship between hemoglobin saturation (SaO2) and partial pressure of dissolved oxygen (pO2) in breast tumors in mice using photoacoustic computed tomographic (PCT) imaging and OxyLite probe, respectively. In its simplest form, the relationship is described by the dissociation curve, or Hill’s equation, for hemoglobin, and is modeled as a sigmoidal curve that is a function of two parameters – the Hill coefficient, n, and the net association constant of HbO2, K (or pO2 at 50% SaO2). First, a calibration study to validate …