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Full-Text Articles in Medicine and Health Sciences
Change In Processing Speed And Its Associations With Cerebral White Matter Microstructure, Muzamil Arshad
Change In Processing Speed And Its Associations With Cerebral White Matter Microstructure, Muzamil Arshad
Wayne State University Dissertations
The decline of cognition with age is one of the most feared aspects of aging, while the slowing of responses, or reduced processing speed, is one of the most reliable aspects of aging. Slowing of processing has been hypothesized to affect other domains of cognition as well. Despite the well-known slowing-age relationship and central position processing speed plays in theories of cognitive aging the neurobiological mechanisms which underpin slowing is unclear. If we could identify the biology associated with processing speed we could then attempt to develop interventions to mitigate the effects of age on those variables. In turn we …
Neural Circuitry Deficits Associated With Dysfunctional Myelin, Kathleen June Maheras
Neural Circuitry Deficits Associated With Dysfunctional Myelin, Kathleen June Maheras
Wayne State University Dissertations
In the current study, we have generated mutant mice that lack Claudin 11 (Cldn11) tight junctions in CNS myelin sheaths. In myelin sheaths, Cldn11 forms tight junctions located along the outer and inner edges of the membrane spiral, preventing ions and small molecules from entering the intramyelinic space. The function of Cldn11 tight junctions is to improve the passive properties of the myelin membrane, by increasing membrane resistance and reducing capacitance, thereby improving the speed of saltatory conduction. In the absence of Cldn11, conduction velocity is slowed, most dramatically in small diameter myelinated fibers, somewhat analogous to reducing myelin thickness. …