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In Vitro Efficacy Of Combined Macrophage-Mediated Plasmonic Photothermal Therapy And Chemotherapeutic Agents, En Chung Shih

UNLV Theses, Dissertations, Professional Papers, and Capstones

Although both chemotherapy and hyperthermia therapy have their inherent advantages, the non-specific targeting of chemotherapy and ineffectiveness of hyperthermia therapy alone suggests a better method can be developed. To overcome this problem, the combined treatment of chemotherapeutic agents with plasmonic photothermal therapy (PPTT) is proposed. This is the first study to investigate the efficacy of combined chemotherapy and PPTT using monocytes as delivery vehicles for gold nanoshells. The results of this investigation shows that PPTT combined with cisplatin resulted in some degree of synergism while additive effects were observed for concurrent treatments of PPTT and doxorubicin and PPTT and bleomycin.