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Full-Text Articles in Medicine and Health Sciences
Detection Of Helicobacter Pylori By Invasive Tests In Adult Dyspeptic Patientsand Antibacterial Resistance To Six Antibiotics, Including Rifampicin In Turkey. Isclarithromycin Resistance Rate Decreasing?, Mustafa Akar, Fuat Aydin, Tuba Kayman, Seçi̇l Abay, Emre Karakaya
Detection Of Helicobacter Pylori By Invasive Tests In Adult Dyspeptic Patientsand Antibacterial Resistance To Six Antibiotics, Including Rifampicin In Turkey. Isclarithromycin Resistance Rate Decreasing?, Mustafa Akar, Fuat Aydin, Tuba Kayman, Seçi̇l Abay, Emre Karakaya
Turkish Journal of Medical Sciences
Background/aim: The prevalence of Helicobacter pylori is reported to be roughly 80% in Turkey, and only very few culture-based studies are available on antibacterial resistance in adult dyspeptic patients. This study was carried out in adult dyspeptic patients with an aim to: (i) detect H. pylori by invasive tests (culture, polymerase chain reaction, and histopathology) and (ii) determine the current resistance rates of H. pylori isolates to six antibiotics, including rifampicin. Materials and methods: This study was conducted in 422 adult dyspeptic patients. The presence of H. pylori was demonstrated by culture, polymerase chain reaction, and the histopathology of gastric …
Relationship Between Helicobacter Pylori Infection And Pityriasis Versicolor:Can Helicobacter Pylori Infection Be A New Etiologic Factor For Pityriasis Versicolor?, Ömer Kutlu, Zeynal Doğan, Hati̇ce Meral Ekşi̇oğlu, Murat Keki̇lli̇
Relationship Between Helicobacter Pylori Infection And Pityriasis Versicolor:Can Helicobacter Pylori Infection Be A New Etiologic Factor For Pityriasis Versicolor?, Ömer Kutlu, Zeynal Doğan, Hati̇ce Meral Ekşi̇oğlu, Murat Keki̇lli̇
Turkish Journal of Medical Sciences
Background/aim: H. pylori has been found to be related to certain dermatological diseases. However, there is no data as yet to propose an association between H. pylori and pityriasis versicolor. In this study, we aimed to evaluate the association between H. pylori and pityriasis versicolor. Materials and methods: This was a prospective study performed in the Gastroenterology and Dermatology and Venereology departments of the Health Sciences University, Ankara Training and Research Centre. A total of 57 consecutive patients (27 pityriasis versicolor, 30 telogen effluvium) were enrolled from the Department of Dermatology and Venereology. All patients were screened for H. pylori …
Effects Of Ankaferd Hemostat On Helicobacter Pylori Strains And Antibiotic Resistance, Rafi̇ye Çi̇ftçi̇ler, Ahmet Koluman, İbrahi̇m Celaletti̇n Haznedaroğlu, Nejat Akar
Effects Of Ankaferd Hemostat On Helicobacter Pylori Strains And Antibiotic Resistance, Rafi̇ye Çi̇ftçi̇ler, Ahmet Koluman, İbrahi̇m Celaletti̇n Haznedaroğlu, Nejat Akar
Turkish Journal of Medical Sciences
Background/aim: Ankaferd hemostat (ABS; Ankaferd blood stopper, İstanbul, Turkey) is a folkloric medicinal plant extract. The aim of this study was to determine the effect of Ankaferd hemostat (ABS) on the fate of Helicobacter pylori strains. The study also aims to determine alterations in the antimicrobial resistance of three different H. pylori strains in response to ABS exposure.Materials and methods: H. pylori Strain 1 was obtained from the culture collection ATCC 43504 and passaged three times for viability. Strain 2 was isolated from a gastric ulcer patient and Strain 3 was isolated from a gastritis patient. 1% of ABS was …
Prevalence And Risk Factors For Helicobacter Pylori Infection In Southwest China: A Study Of Health Examination Participants Based On 13c-Urea Breath Test, Jie Liu, Yonghong Wang, Qinghua Zhao, Rong Luo, Mingzhao Xiao, Mingjun Zhang, Weibo Xie
Prevalence And Risk Factors For Helicobacter Pylori Infection In Southwest China: A Study Of Health Examination Participants Based On 13c-Urea Breath Test, Jie Liu, Yonghong Wang, Qinghua Zhao, Rong Luo, Mingzhao Xiao, Mingjun Zhang, Weibo Xie
Turkish Journal of Medical Sciences
Background/aim: Helicobacter pylori (H. pylori) has a high prevalence in developing countries. We aimed to investigate the current prevalence of H. pylori, as well as its potential serum risk factors, in a population from southwest China.Materials and methods: This cross-sectional study included 10,912 subjects who received medical examinations at the First Affiliated Hospital of Chongqing Medical University in 2014. Data regarding physical examinations and biochemical measurements were collected, and H. pylori infection was diagnosed with a 13C-urea breath test. Logistic regression was conducted to identify the risk factors for H. pylori infection.Results: The infection rate of H. pylori was 34.4% …
The Role Of Outer Inflammatory Protein A (Oipa) In Vaccination Of Thec57bl/6 Mouse Model Infected By Helicobacter Pylori, Mohaddese Mahboubi, Tahereh Falsafi, Majid Sadeghizadeh, Fatemeh Mahjoub
The Role Of Outer Inflammatory Protein A (Oipa) In Vaccination Of Thec57bl/6 Mouse Model Infected By Helicobacter Pylori, Mohaddese Mahboubi, Tahereh Falsafi, Majid Sadeghizadeh, Fatemeh Mahjoub
Turkish Journal of Medical Sciences
Background/aim: Outer inflammatory protein A (OipA) is an important adhesin of Helicobacter pylori. Our goal was to assess the role of OipA in protection of C57BL/6 mice against H. pylori. Materials and methods: C57BL/6 mice were mucosally immunized with recombinant OipA protein, OipA + propolis, propolis, and phosphate-buffered saline. After vaccination, anti-OipA IgA was measured. Mice were challenged three times with 5 x 107 CFU of the H. pylori B19 strain. Two weeks later, bacterial colonization and inflammation in the stomach was analyzed using standard methods. Results: The CFU number in the OipA group was significantly (P < 0.05) lower than that of the control. The CFU number in the OipA + propolis group was higher than those of the OipA and propolis groups. IgA titers were significantly higher (P < 0.0001) in the OipA group compared to the control and OipA + propolis groups. Propolis did not play an adjuvant effect but it interfered with the efficient vaccine effect of OipA. Conclusion: Results show the effect of vaccination by OipA in protection of the mouse model and the importance of OipA in H. pylori pathogenesis. OipA may be proposed as a suitable oral vaccine candidate against H. pylori infection; however, further study is required to determine adjuvant or adverse effects of propolis toward OipA.
Efficient Production Of Nanobodies Against Urease Activity Ofhelicobacter Pylori In Pichia Pastoris, Shahrbanoo Pourasadi, Seyed Latif Mousavi Gargari, Masoumeh Rajabibazl, Shahram Nazarian
Efficient Production Of Nanobodies Against Urease Activity Ofhelicobacter Pylori In Pichia Pastoris, Shahrbanoo Pourasadi, Seyed Latif Mousavi Gargari, Masoumeh Rajabibazl, Shahram Nazarian
Turkish Journal of Medical Sciences
Background/aim: Helicobacter pylori is a major health problem. One of the therapeutic approaches is administration of antibody against H. pylori. The methylotrophic Pichia pastoris is a suitable host for expression of recombinant antibody fragments. The aims of this study were the expression and the evaluation of camelid nanobody in the yeast Pichia pastoris. Materials and methods: The camelid-derived heavy-chain antibody (nanobody) against the UreC subunit of urease from H. pylori was subcloned in the pPink-HC shuttle vector and transferred into Escherichia coli TOP10. After digestion and purification, the shuttle vector was transformed in the PichiaPink expression system. The expression was …
Comparative Analysis Of Selected Cagpai Genes And Different Vaca Genotypes In Iranian And Turkish H. Pylori-Positive Patients Suffering From Gastric Adenocarcinoma And Active Chronic Gastritis, Ali Bahadori, Mohammad Hossein Somi, Fi̇gen Doran, Amir Taher Eftekharsadat, Suna Kizilyildirim, Mahsa Esmaeillou, Maryam Yassi, Başak Bedi̇r, Fati̇h Köksal
Comparative Analysis Of Selected Cagpai Genes And Different Vaca Genotypes In Iranian And Turkish H. Pylori-Positive Patients Suffering From Gastric Adenocarcinoma And Active Chronic Gastritis, Ali Bahadori, Mohammad Hossein Somi, Fi̇gen Doran, Amir Taher Eftekharsadat, Suna Kizilyildirim, Mahsa Esmaeillou, Maryam Yassi, Başak Bedi̇r, Fati̇h Köksal
Turkish Journal of Medical Sciences
Background/aim: Helicobacter pylori is a pathogen that colonizes a majority of the world's population. Genetic diversity within the virulence genes of bacteria such as cagPAI and vacA may have a modified effect on the pathogenic potential of the bacteria. This study aimed to investigate which genes can be suggested as potentially related virulence factors for H. pylori-associated active chronic gastritis and stomach adenocarcinoma in the northwest of Iran and south of Turkey. Materials and methods: Formalin-fixed, paraffin-embedded stomach biopsy tissue samples were obtained from Iranian and Turkish patients from selected geographical regions. The prevalence of selected cagPAI genes and vacA …
Correlation Between Serum Levels Of Vitamin B12 And Anti-Helicobacter Pyloriiga Antibodies In Vitamin B12 Deficient Palestinian Patients, Rasmi Abu Hilu, Osama Dudeen, Sameer Abdullatif Barghouthi
Correlation Between Serum Levels Of Vitamin B12 And Anti-Helicobacter Pyloriiga Antibodies In Vitamin B12 Deficient Palestinian Patients, Rasmi Abu Hilu, Osama Dudeen, Sameer Abdullatif Barghouthi
Turkish Journal of Medical Sciences
Background/aim: H. pylori infection and vitamin B12 (vB12) deficiency have high prevalence rates among Palestinians. It was observed that most people who suffered from vB12 deficiency were positive for H. pylori. Materials and methods: The correlation between H. pylori infection and vB12 deficiency was investigated in a representative segment of the Palestinian population. ELISA was used to determine levels of vitamin B12 (vB12) and anti-H. pylori IgA in sera from 238 participants from Al-Khalil district (Hebron), Palestine. Results: There was a strong negative Pearson's correlation coefficient (r = -0.45; P = 0.00001) between levels of anti-H. pylori IgA and vB12 …
Prevalence Of Helicobacter Pylori Caga, Baba2, And Dupa Genotypes Andcorrelation With Clinical Outcome In Malaysian Patients With Dyspepsia, Hussein Ali Osman, Habsah Hasan, Rapeah Suppian, Syed Hassan, Dzulkarnaen Zakaria Andee, Noorizan Abdul Majid, Bin Alwi Zilfalil
Prevalence Of Helicobacter Pylori Caga, Baba2, And Dupa Genotypes Andcorrelation With Clinical Outcome In Malaysian Patients With Dyspepsia, Hussein Ali Osman, Habsah Hasan, Rapeah Suppian, Syed Hassan, Dzulkarnaen Zakaria Andee, Noorizan Abdul Majid, Bin Alwi Zilfalil
Turkish Journal of Medical Sciences
Background/aim: The severity of disease outcome in dyspepsia has been attributed to Helicobacter pylori virulence genes. The aim of this study was to determine the distribution of H. pylori virulence genes (cagA, babA2, and dupA) and to determine whether or not there arises a significant correlation with clinical dyspepsia outcomes. Materials and methods: H. pylori genotypes cagA, babA2, and dupA were identified by polymerase chain reactions from gastric biopsy samples in 105 H. pylori-positive patients. Results: The positive rates for cagA, babA2, and dupA genes in H. pylori dyspeptic patients were 69.5%, 41.0%, and 22.9%, respectively. cagA was more prevalent …
Analysis Of Vaca/Caga Genotypes/Status In Helicobacter Pylori Isolates From Iranian Children And Their Association With Clinical Outcome, Tahereh Falsafi, Afsaneh Khani, Fatemeh Mahjoub, Ezat Asgarani, Nazli Sotoudeh
Analysis Of Vaca/Caga Genotypes/Status In Helicobacter Pylori Isolates From Iranian Children And Their Association With Clinical Outcome, Tahereh Falsafi, Afsaneh Khani, Fatemeh Mahjoub, Ezat Asgarani, Nazli Sotoudeh
Turkish Journal of Medical Sciences
More than 50% of Iranian children are infected with Helicobacter pylori; however, no data exist about the association of vacA/cagA genotype/status with disease outcomes in them. We analyzed association of vacA/cagA genotypes/status of children's isolates with gastric inflammation status as the first step in H. pylori pathogenesis. Materials and methods: Antral biopsies for culture and histopathology were taken from 328 children in 1997-2009. vacA (s, m) alleles and cagA statuses of the isolates were determined by PCR. Histopathology was performed according to the Sydney system; gastritis was scored as normal, mild, moderate, severe, and follicular. Results: A total of 159 …
Investigation Into The Frequency Of Helicobacter Pylori Infection With Carbon 14 Urea Breath Test In Patients With Vitiligo, Emi̇ne Nur Ri̇fai̇oğlu, Füsun Aydoğan, Bi̇lge Bülbül Şen, Tuğba Şen, Özlem Eki̇z
Investigation Into The Frequency Of Helicobacter Pylori Infection With Carbon 14 Urea Breath Test In Patients With Vitiligo, Emi̇ne Nur Ri̇fai̇oğlu, Füsun Aydoğan, Bi̇lge Bülbül Şen, Tuğba Şen, Özlem Eki̇z
Turkish Journal of Medical Sciences
Vitiligo is a common, acquired depigmenting skin disorder. The relationship between Helicobacter pylori (HP) infection and autoimmune dermatological disease has been previously reported. However, the frequency of HP infection in patients with vitiligo has not been reported. In this study, we aimed to investigate the frequency of HP infection with the carbon 14 (C14) urea breath test (UBT) in patients with vitiligo. Materials and methods: This study included 34 patients (18 males and 16 females) with vitiligo and 30 age- and sex-matched healthy controls. HP infection was diagnosed using the C14 UBT (Heliprobe). Statistical analysis was performed using SPSS 19. …
What Is The Effect Of Radioiodine Therapy On Helicobacter Pylori Infection?, Celi̇l Alper Usluoğullari, Eda Demi̇r Önal, Eli̇f Özdemi̇r, Sedat Caner, Osman Ersoy, Reyhan Ersoy, Beki̇r Çakir
What Is The Effect Of Radioiodine Therapy On Helicobacter Pylori Infection?, Celi̇l Alper Usluoğullari, Eda Demi̇r Önal, Eli̇f Özdemi̇r, Sedat Caner, Osman Ersoy, Reyhan Ersoy, Beki̇r Çakir
Turkish Journal of Medical Sciences
Helicobacter pylori is an important human pathogen associated with gastric and duodenal ulcers, gastric mucosa-associated lymphoid tissue lymphoma, and adenocarcinoma. Radioiodine (RAI) treatment plays an important role in the management of differentiated thyroid cancer and primary hyperthyroidism. It is known that during RAI treatment, a considerable amount is absorbed by the stomach as well. In this study we aimed to reveal any therapeutic impact of RAI on H. pylori infections. Materials and methods: Eighty-seven patients who were hospitalized for RAI treatment were consecutively included in this study. Of those, 76 patients had differentiated thyroid cancer and 11 had primary hyperthyroidism. …
The Relation Between Helicobacter Pylori And Ulcerative Colitis, Sedat Caner, Aki̇f Altinbaş, Yusuf Yeşi̇l, Yavuz Beyazit, Bariş Yilmaz, Osman Yüksel
The Relation Between Helicobacter Pylori And Ulcerative Colitis, Sedat Caner, Aki̇f Altinbaş, Yusuf Yeşi̇l, Yavuz Beyazit, Bariş Yilmaz, Osman Yüksel
Turkish Journal of Medical Sciences
Besides some genetic explanations of the native course of ulcerative colitis (UC), the most attributable factors are pathogenic bacterial agents. There are some conflicting data about the relationship between Helicobacter pylori and the rate of UC in the literature. Therefore, we aimed to investigate the rate of H. pylori in UC patients. Materials and methods: Forty-nine individuals diagnosed with UC who had undergone upper gastrointestinal tract endoscopy for different reasons were included in the study. The presence of H. pylori in the stomach was checked by histopathological examination. Results: H. pylori positivity was present in 57.1% of patients with UC. …
Detection Of Caga And Vaca Genotypes Of Helicobacter Pylori Isolates From A University Hospital In Ankara Region, Turkey, Ceren Erdoğdu, Zeynep Saribaş, Yakut Akyön Yilmaz
Detection Of Caga And Vaca Genotypes Of Helicobacter Pylori Isolates From A University Hospital In Ankara Region, Turkey, Ceren Erdoğdu, Zeynep Saribaş, Yakut Akyön Yilmaz
Turkish Journal of Medical Sciences
The cagA and vacA profiles and their association with clinical findings show a distinct geographical distribution. In the present study, we aimed to determine the cagA status and vacA allelic subtypes in strains isolated from a university hospital in Ankara and to evaluate their associations with histopathological and endoscopic findings. Materials and methods: A total of 120 H. pylori strains from stock cultures positive for the ureA gene were randomly included in the present study. Of these strains, cagA and vacA allelic subtypes (s1a, s1b, s2, m1, m2) were examined by polymerase chain reaction. Results: Of the 120 strains, 64 …
Helicobacter Pylori Infection And Relationship With Gastric Epithelial Cell Proliferation And Apoptosis, Zühal Güci̇n, Tuğba Çakmak, Ni̇zametti̇n Bayyurt, Bari̇k Sali̇h
Helicobacter Pylori Infection And Relationship With Gastric Epithelial Cell Proliferation And Apoptosis, Zühal Güci̇n, Tuğba Çakmak, Ni̇zametti̇n Bayyurt, Bari̇k Sali̇h
Turkish Journal of Medical Sciences
To evaluate the effects of Helicobacter pylori on cell proliferation and apoptosis in gastric cancer (GC) both at tumoral and nontumoral sites and in gastritis. Materials and methods: Biopsies from 96 patients (gastric cancer = 52, gastritis = 44) were examined immunohistochemically and histopathologically. Results: In H. pylori-positive GC patients the average proliferative index (PI) in tumor and nontumor sites was 40.7% and 24.8%, while in H. pylori-negative patients it was 32.9% and 17.8%, respectively. The PI was significantly higher in the tumor than in the nontumor sites, regardless of H. pylori infection. Cell proliferation was also significantly associated with …
The Distribution Of Telomerase Activity In Patients With Helicobacter Pylori Positive Gastritis, Nai̇me Canoruç, Ebru Kale, Şeri̇f Yilmaz, Kadi̇m Bayan, Mehmet Dursun, Sabri̇ Batun, Abdurrahman Kaplan
The Distribution Of Telomerase Activity In Patients With Helicobacter Pylori Positive Gastritis, Nai̇me Canoruç, Ebru Kale, Şeri̇f Yilmaz, Kadi̇m Bayan, Mehmet Dursun, Sabri̇ Batun, Abdurrahman Kaplan
Turkish Journal of Medical Sciences
Helicobacter pylori is considered a class I carcinogen by the World Health Organization. We aimed to determine whether H. pylori has an effect on telomerase activity in patients with H. pylori related non-specific gastritis, atrophy, and intestinal metaplasia. Materials and methods: One hundred and seventy-two adult patients who underwent upper gastroduodenoscopy were enrolled in the study. Three biopsy specimens were taken from the antrum: 1 from the incisura angularis and 2 from the mid-antrum. Biopsy specimens taken from the incisura angularis were evaluated using the urease test for detection of H. pylori. The mid-antrum specimens were sent for histopathology and …
Prevalence Of Helicobacter Pylori Infection In Healthcare Workers, Maliheh Metanat, Batool Sharifi-Mood, Shahrokh Izadi
Prevalence Of Helicobacter Pylori Infection In Healthcare Workers, Maliheh Metanat, Batool Sharifi-Mood, Shahrokh Izadi
Turkish Journal of Medical Sciences
Helicobacter pylori (H. pylori) is a major factor in inflammatory and malignant diseases of the gastrointestinal tract. The epidemiologic pattern of this infection varies among developed and developing countries, and is related to the general standards of living in each region. In view of the importance of this infection and its different prevalence in different regions of Iran, as well as its long-term complications, this study was conducted to investigate the prevalence of H. pylori infection and its contributing factors in Zahedan. Materials and methods: Ninety-seven healthcare workers without digestive symptoms or a history of H. pylori eradication were randomly …
Clinical And Pathological Features Of Nodular Gastritis In Adults, İbrahi̇m Koral Önal, Cenk Sökmensüer, Eda Demi̇r Önal, Osman Ersoy, Özgür Yeni̇ova, Musa Aydinli, Özlem Yönem, Özgür Harmanci, Yusuf Bayraktar, Fi̇gen Batman
Clinical And Pathological Features Of Nodular Gastritis In Adults, İbrahi̇m Koral Önal, Cenk Sökmensüer, Eda Demi̇r Önal, Osman Ersoy, Özgür Yeni̇ova, Musa Aydinli, Özlem Yönem, Özgür Harmanci, Yusuf Bayraktar, Fi̇gen Batman
Turkish Journal of Medical Sciences
Aim: Data on antral nodularity in adults are sparse. Although the association of nodular gastritis with Helicobacter pylori infection is well known, its potential as a premalignant lesion and its association with other gastroduodenal diseases are questionable. Materials and methods: The medical records of the patients between 2003 and 2006 were retrospectively reviewed to analyze their demographics, clinical characteristics, and endoscopic and pathological features. Results: Of 9949 adult patients who underwent endoscopy, 185 (1.86%) were diagnosed with nodular gastritis, 167 (90%) of whom had dyspepsia. The presence of Helicobacter pylori was demonstrated in 65.4% (121/185). There were 16 cases (8.7%) …
Insulin Sensitivity, B Cell Function And Serum Lipid Levels In Helicobacter Pylori Positive, Non-Obese, Young Adult Males, Mehmet Dursun, Mi̇that Bahceci̇, Alpaslan Tuzcu, Şeri̇f Yilmaz, Fi̇kri̇ Canoruç
Insulin Sensitivity, B Cell Function And Serum Lipid Levels In Helicobacter Pylori Positive, Non-Obese, Young Adult Males, Mehmet Dursun, Mi̇that Bahceci̇, Alpaslan Tuzcu, Şeri̇f Yilmaz, Fi̇kri̇ Canoruç
Turkish Journal of Medical Sciences
It is not clear whether Helicobacter pylori (Hp) infection affects insulin levels and insulin sensitivity. We aimed to determine insulin sensitivity and beta cell function, and to evaluate serum lipids in subjects with and without Hp infection. Eighty non-obese young adult males, 40 of whom were Hp positive and 40 were negative, were included in the study. Two endoscopic biopsy specimens were obtained from each subject. Height, weight and waist-hip circumference were measured, and body mass index (BMI) was calculated. Serum glucose, total, HDL, LDL and VLDL-cholesterol and triglyceride levels were determined. Body fat mass and percentage were determined by …
The Frequency Of Helicobacter Pylori In Various Gastric Mucosal Appearances, Mehmet Dursun, Mustafa Karabulut, Fi̇kri̇ Canoruç, Şeri̇f Yilmaz, Mehmet Yaldiz
The Frequency Of Helicobacter Pylori In Various Gastric Mucosal Appearances, Mehmet Dursun, Mustafa Karabulut, Fi̇kri̇ Canoruç, Şeri̇f Yilmaz, Mehmet Yaldiz
Turkish Journal of Medical Sciences
Our purpose was to investigate whether Helicobacter pylori (Hp) has a specific mucosal appearance. Eighty-eight (female / male: 53/35) patients included in the study underwent endoscopy to determine the macroscopic appearance of their gastric mucosa. Biopsies taken from the antrum, incisura angularis and corpus of each patient were stained with toluidine blue and examined for Hp under a light microscope. Thirty were Hp negative and 58 Hp positive. Thirty-six percent of the patients had normal mucosa, 21.59% had spotty erythema in the antrum, 31.81% had a mosaic pattern in the antrum and/or corpus and 10.23% had acute duodenal ulcer. Fifty-six …
The Isolation Rate And Antibiotic Resistantpattern Of Helicobacter Pylori In Dyspepticpatients, Esra Ağel, Bengül Durmaz, Mehmet Refi̇k Tevfi̇k, Nergi̇s Aşgin
The Isolation Rate And Antibiotic Resistantpattern Of Helicobacter Pylori In Dyspepticpatients, Esra Ağel, Bengül Durmaz, Mehmet Refi̇k Tevfi̇k, Nergi̇s Aşgin
Turkish Journal of Medical Sciences
In order to determine the isolation rates of Helicobacter pylori in dyspeptic patients, 167 biopsy specimens were examined using different methods, including culturing, microscopy and the rapid urease test. Resistance to commonly used antimicrobials was investigated using the disk diffusion method. Of the 167 specimens, 82(49.1%) were found to be positive for Helicobacter pylori in culture and 72(43 %) were positive in the urease biopsy test. Using Gram staining, Helicobacter pylori were observed in 43 (25.7 %) of the specimens. The resistance rate of the isolates was 53 % for metronidazol, 8% for both clarithromycin and ciprofloxacin, and 4% for …
Helicobacter Pylori Seropositivity In Children Withrecurrent Abdominal Pain, Engin Günel, Duygu Findik, Fatma Çağlayan, Zerrin Topgaç
Helicobacter Pylori Seropositivity In Children Withrecurrent Abdominal Pain, Engin Günel, Duygu Findik, Fatma Çağlayan, Zerrin Topgaç
Turkish Journal of Medical Sciences
Recurrent abdominal pain (RAP) is a significant problem in pediatric patients, and there has been much recent interest in the role that Helicobacter pylori (Hp) might play in this disorder. The aim of the study was to determine the prevalance of Hp infection in children with RAP, and to determine whether there was an association between Hp and RAP. The study was conducted on 50 children with RAP and 20 asymptomatic children admitted for inguinal surgery as a control group. Serum samples from the 70 children were tested for anti-Hp Ig G and anti-Hp Ig A by ELISA. Of the …