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Full-Text Articles in Medicine and Health Sciences
The Role Of Curcumin On Apoptosis And Nlrp3 Inflammasome-Dependent Pyroptosis On Colorectal Cancer In Vitro, Zeynep Dal, Başak Aru
The Role Of Curcumin On Apoptosis And Nlrp3 Inflammasome-Dependent Pyroptosis On Colorectal Cancer In Vitro, Zeynep Dal, Başak Aru
Turkish Journal of Medical Sciences
Background/aim: Colorectal cancer (CRC) is one of the most common cancers worldwide. Many factors such as stress, lifestyle, and dietary habits are known to play a role in the initiation and progression of the disease. Herbal therapeutic agents including curcumin can hold a great potential against cancer treatment; however, their efficacy on CRC is still under investigation. Herein, we evaluated the anticancer mechanism of curcumin on four different CRC cell lines. Materials and methods: Cells were treated with curcumin for 24, 48 and 72 h, and IC50 doses for each cell line were calculated. Mechanistic studies were conducted with the …
The Effect Of Immunonutrition On Tumor Infiltrative T Lymphocytes And Regulatory T Cells In Rectal Tumor Patients Receiving Neoadjuvant Chemoradiotherapy: A Prospective Randomized Clinical Study, Mehmet Onur Gül, Cebrai̇l Akyüz, Selvi̇naz Özkara
The Effect Of Immunonutrition On Tumor Infiltrative T Lymphocytes And Regulatory T Cells In Rectal Tumor Patients Receiving Neoadjuvant Chemoradiotherapy: A Prospective Randomized Clinical Study, Mehmet Onur Gül, Cebrai̇l Akyüz, Selvi̇naz Özkara
Turkish Journal of Medical Sciences
Background/aim: The rationale behind using immunonutrition in cancer patients is to prevent malnutrition, manage the host's immune response, and keep cancer under control by utilizing the potential immune system available in the host against the tumor. This prospective- study aims to assess the impact of immunonutrition on tumor-infiltrating lymphocytes (TILs) and regulatory T cells (Tregs) in rectal cancer patients receiving neoadjuvant chemoradiotherapy. Materials and methods: This is a single-center, prospective study. Forty patients diagnosed with middle and lower rectal tumors were enrolled in the study between March 2018 and December 2019. Nutrition protocols were given to all study subjects prior …
The Role Of Pericytes On The Efficacy Of Bevacizumab In Colorectal Cancer, Merve Besler, Fatma Sena Dost, Fi̇li̇z Çay Şenler, Bi̇lge Ayça Kirmizi, Berna Savaş, Hakan Akbulut
The Role Of Pericytes On The Efficacy Of Bevacizumab In Colorectal Cancer, Merve Besler, Fatma Sena Dost, Fi̇li̇z Çay Şenler, Bi̇lge Ayça Kirmizi, Berna Savaş, Hakan Akbulut
Turkish Journal of Medical Sciences
Background/aim: Pericytes are mesenchymal cells surrounding capillary vessels and are known to play an essential role in tumor angiogenesis. Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface proteoglycan and its release from pericytes and vascular smooth muscle cells is very important in tumor angiogenesis. Bevacizumab, which is a monoclonal antibody frequently used in the treatment of metastatic colorectal cancer, binds to the ligand of vascular endothelial growth factor A (VEGFA) and inhibits tumor angiogenesis. However, no reliable biomarker for predicting patients that will show a good response to this therapy has been established yet. In this study, we aimed …
Muc1 And Muc5ac Implication In Tunisian Colorectal Cancer Patients, Meriam Hazgui, Marwa Weslati, Rahma Boughriba, Donia Ounissi, Dhouha Bacha, Saadia Bouraoui
Muc1 And Muc5ac Implication In Tunisian Colorectal Cancer Patients, Meriam Hazgui, Marwa Weslati, Rahma Boughriba, Donia Ounissi, Dhouha Bacha, Saadia Bouraoui
Turkish Journal of Medical Sciences
Background/aim: Mucins, such as MUC1 and MUC5AC, are known for their protective and moisturizing role in intestinal epithelium. Their expression is tightly controlled given their essential role in normal tissue homeostasis, whereas their deregulation leads to chronic inflammation, and even cancer. This study aimed to assess the expression profiles of MUC1 and MUC5AC and their implications in colorectal carcinogenesis. Materials and methods: A retrospective study of 202 patients who underwent colorectal cancer (CRC) surgery was conducted. The expression of MUC1 and MUC5AC was investigated by immunohistochemistry and reverse-transcription polymerase chain reaction (RT-PCR). Statistical analysis of mucin expression pattern, as well …
Efficacy Of The Population-Based Pilot Colorectal Cancer Screening, Csongrád County,Hungary, 2015, Mariann Rutka, Renáta Bor, Tamás Molnár, Klaudia Farkas, Anna Fábián, Márk Györffy, Anita Bálint, Ágnes Milassin, Mónika Szücs, László Tiszlavicz, Ferenc Nagy, Zoltán Szepes
Efficacy Of The Population-Based Pilot Colorectal Cancer Screening, Csongrád County,Hungary, 2015, Mariann Rutka, Renáta Bor, Tamás Molnár, Klaudia Farkas, Anna Fábián, Márk Györffy, Anita Bálint, Ágnes Milassin, Mónika Szücs, László Tiszlavicz, Ferenc Nagy, Zoltán Szepes
Turkish Journal of Medical Sciences
Background/aim: In Hungary, a nationwide colorectal screening program is about to be introduced in order to improve the high mortality rate of colorectal cancer (CRC). The aim was to summarize experiences from and assess short-term efficacy of the populationbased pilot colorectal screening program in 2015 in Csongrád county, Hungary. Materials and methods: Asymptomatic individuals between the ages of 50 and 70 with average risk of colorectal cancer participated in the program that was based on the two-step screening method: immune fecal blood test and colonoscopy. The short-term efficacy was assessed as the change in total CRC incidence and initial tumor …
Spectrum Of Germline Cancer Susceptibility Gene Mutations In Turkish Colorectal Cancer Patients: A Single Center Study, Haktan Bağiş Erdem, Taha Bahsi̇
Spectrum Of Germline Cancer Susceptibility Gene Mutations In Turkish Colorectal Cancer Patients: A Single Center Study, Haktan Bağiş Erdem, Taha Bahsi̇
Turkish Journal of Medical Sciences
Background/aim: Quarter of colorectal cancer patients have a family history and 6% of these comprise hereditary cancer syndromes. For developing national health strategies for genetic screening, it is crucial to determine the spectrum of damaging alterations in causative genes and to describe frequent founder mutations. Materials and methods: One hundred and thirty six unrelated colorectal cancer cases were investigated. Qiagen large hereditary cancer panel and Hereditary Cancer Solution v1.1 panel were used for sequencing. The sequencing process was performed on the Illumina MiSeq system. The data analyses were performed on QIAGEN Clinical Insight (QCITM) Analyze software and Sophia DDM software. …
Evaluation Of Risk Factors For The Recurrence Of Colorectal Polyps And Colorectal Cancer, Öztürk Ateş, Bülent Si̇vri̇, Saadetti̇n Kiliçkap
Evaluation Of Risk Factors For The Recurrence Of Colorectal Polyps And Colorectal Cancer, Öztürk Ateş, Bülent Si̇vri̇, Saadetti̇n Kiliçkap
Turkish Journal of Medical Sciences
Background/aim: Colorectal adenomatous polyps are precursors of colorectal cancer (CRC), which can be prevented with surveillance colonoscopy. This study aimed to assess risk factors for the recurrence of colorectal polyps and CRC following polypectomy. Materials and methods: In this single-center trial, a total of 510 patients who applied to the endoscopy unit of Hacettepe University Hospital for various reasons and who were diagnosed with at least one colorectal adenomatous polyp between 2000 and 2010 were retrospectively analyzed. Patients with colorectal adenomatous polyps or CRC recurrences were examined in terms of clinical and histological risk factors. Results: A total of 190 …
Polymorphisms Of Cancer-Related Genes And Risk Of Multipleprimary Malignancies Involving Colorectal Cancer, Peiguo Cao, Li Yu, Anshan Wu, Jingjing Li, Ling Liu, Chunlan Liu, Jianda Zhou, Ke Cao, Chengxian Guo
Polymorphisms Of Cancer-Related Genes And Risk Of Multipleprimary Malignancies Involving Colorectal Cancer, Peiguo Cao, Li Yu, Anshan Wu, Jingjing Li, Ling Liu, Chunlan Liu, Jianda Zhou, Ke Cao, Chengxian Guo
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of cancer-related genes and the risk of multiple primary malignancies involving colorectal cancer.Materials and methods: We collected tissue samples from 22 multiple primary cancer patients with primary colorectal cancer and performed genotyping assay for 116 SNP loci from 62 genes encoding peptides functioning in various signaling pathways using the DNA MassARRAY system. The chi-square test was used to compare the differences in base frequencies between patients and a control Chinese population from HapMap through the NCBI database.Results: No significant differences in frequencies were detected for 81 SNPs …
The Frequency Of Human Papillomaviruses In Colorectal Cancer Samples In Mashhad, Northeastern Iran, Mojtaba Meshkat, Naser Tayyebi Meibodi, Samaneh Sepahi, Narges Fadaee, Masoumeh Salehpour, Zahra Meshkat
The Frequency Of Human Papillomaviruses In Colorectal Cancer Samples In Mashhad, Northeastern Iran, Mojtaba Meshkat, Naser Tayyebi Meibodi, Samaneh Sepahi, Narges Fadaee, Masoumeh Salehpour, Zahra Meshkat
Turkish Journal of Medical Sciences
Infection with the human papillomaviruses (HPVs) is associated with the development of several cancers, including oral, esophageal, skin, lung, and cervical. However, the association of HPVs and colorectal cancers remains controversial. The aim of this study was to evaluate the association between HPV infection and paraffin-embedded colorectal tissue samples in Mashhad in the northeast of Iran. Materials and methods: Paraffin-embedded tissue specimens from 111 patients with colorectal cancer were subjected to DNA extraction. The quality of extracted DNA was confirmed by amplification of a b-globin fragment using polymerase chain reaction (PCR) and GH20/PCO4 primers. PCR with GP5+/GP6+ primers was then …
Plasma Soluble Thrombomodulin And Soluble Endothelial Protein C Receptor Levels In Colorectal Cancer Patients, Serap Ünal Ti̇lki̇, Hüseyi̇n Engi̇n, Ayla Gökmen, Cemi̇l Bi̇li̇r, Yücel Üstündağ
Plasma Soluble Thrombomodulin And Soluble Endothelial Protein C Receptor Levels In Colorectal Cancer Patients, Serap Ünal Ti̇lki̇, Hüseyi̇n Engi̇n, Ayla Gökmen, Cemi̇l Bi̇li̇r, Yücel Üstündağ
Turkish Journal of Medical Sciences
Thrombomodulin (TM) and endothelial protein C receptor (EPCR) are 2 transmembrane proteins that are thought to play an important role in cancer. We aimed to discover whether these 2 proteins are prognostic indicators in colorectal cancer. Materials and methods: Plasma TM and EPCR levels were measured using the ELISA method in 50 patients in different tumor stages that had been recently diagnosed with colorectal cancer and in a healthy control group of 50 people. Results: In colorectal cancer patients, higher plasma TM (21.3 ± 22.8 ng/mL, 13.2 ± 16.2 ng/mL, P = 0.010) and plasma EPCR levels (149.9 ± 79.6, …
The Expression Of Cell Adhesion Molecules In Colorectal Cancer Tissue And Its Clinical Values, Dong Chen, Huiying Zhao, Feng Ye
The Expression Of Cell Adhesion Molecules In Colorectal Cancer Tissue And Its Clinical Values, Dong Chen, Huiying Zhao, Feng Ye
Turkish Journal of Medical Sciences
To investigate the role of cell adhesion molecules CD44v6 and CEA in the occurrence, development, and metastasis of colorectal cancer (CRC). Materials and methods: The expression of CD44v6 and CEA in 76 CRC tissues and 43 normal colon tissues was detected using an immunohistological technique. The relationship between the 2 molecules’ expression and their pathologic characteristics, especially for metastasis, was investigated. Furthermore, the relevance between the expression of CD44v6 and of CEA was also assessed. Results: Expression of CD44v6 and CEA protein in CRC tissues was higher than in paracarcinoma tissue and normal colorectal mucosa (both P < 0.001). Positive expression of CD44v6 in CRC was associated with lymph node metastasis, Dukes’ stage, and histological differentiation. Higher expression intensity of CEA in CRC was related to lymph node involvement, distant metastasis, and invasion depth. Combining analysis of CD44v6 and CEA can improve the sensitivity and specificity in evaluating the metastatic potential of CRC (P < 0.05). There was no relevance between the expression of CD44v6 and CEA in CRC (P > 0.05). Conclusion: CD44v6 …
Does Early Enteral Feeding Affect Clinical Outcome Or Cytokine Profiles After Elective Surgery For Colorectal Cancer?, Elizabeth Anne Baker, Lynne Williams, Sanaa El-Gaddal, Fintan Bergin, David John Leaper
Does Early Enteral Feeding Affect Clinical Outcome Or Cytokine Profiles After Elective Surgery For Colorectal Cancer?, Elizabeth Anne Baker, Lynne Williams, Sanaa El-Gaddal, Fintan Bergin, David John Leaper
Turkish Journal of Medical Sciences
Patients who have intestinal cancer are prone to malnutrition, which can result in deterioration of physiological function, poor wound healing, increased risk of infection and prolonged hospital stay. These complications are particularly relevant after colorectal surgery. Early enteral feeding, to enhance nutritional status, has been reported to reduce post-operative complications, length of hospital stay and morbidity and mortality after upper gastro-intestinal cancer surgery. Inflammatory cytokines (IL-6, TNF-a (\alpha)), clinical outcomes and postoperative complications were measured in 147 patients undergoing elective surgery for colorectal cancer (84 standard care; 64 patients had early enteral feeding in addition). There were no significant differences …