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Full-Text Articles in Medicine and Health Sciences
Relationship Between C-Reactive Protein/Albumin Ratio And Mucocutaneous Symptom Frequency And Disease Severity In Behçet’S Disease, Erdal Pala, Mustafa Bayraktar
Relationship Between C-Reactive Protein/Albumin Ratio And Mucocutaneous Symptom Frequency And Disease Severity In Behçet’S Disease, Erdal Pala, Mustafa Bayraktar
Turkish Journal of Medical Sciences
Background/aim: There is no specific marker that can be applied to determine the severity of Behçet’s disease. The aim of this study is to investigate the potential of C-reactive protein (CRP)/albumin (CAR) ratio as a tool for assessing the severity of Behçet’s disease.Materials and methods: A retrospective crosssectional study was conducted by examining hospital archives. The CRP and albumin levels of Behçet’s disease patients who presented to our dermatology clinic over a three-year period from February 2020 to February 2022 were included, along with the identical laboratory parameters in the control group. The CAR ratio was calculated and statistically compared …
Diagnostic Value Of Procalcitonin And C Reactive Protein For Infection And Sepsis Inelderly Patients, Çi̇ler Zi̇nci̇rci̇oğlu, Kazim Rollas, Işil Güldoğan, Aykut Saritaş, Hüseyi̇n Özkarakaş, Gürsel Ersan, Ni̇met Şenoğlu
Diagnostic Value Of Procalcitonin And C Reactive Protein For Infection And Sepsis Inelderly Patients, Çi̇ler Zi̇nci̇rci̇oğlu, Kazim Rollas, Işil Güldoğan, Aykut Saritaş, Hüseyi̇n Özkarakaş, Gürsel Ersan, Ni̇met Şenoğlu
Turkish Journal of Medical Sciences
Background/aim: Biomarkers are useful for diagnosing infection and sepsis in adults, but data are limited in elderly patients. Furthermore, clinical symptoms of infection in elderly patients are usually atypical or unclear. We aimed to assess the usefulness of PCT, CRP, and WBC in distinguishing elderly patients infected with sepsis from infected without sepsis and those with no-infection. We also aimed to find a cut-off value for diagnosing sepsis and infection without sepsis in elderly critically ill patients. Materials and methods: In this single-center and prospective observational study, patients older than 65 years were enrolled. Serum levels of PCT, CRP, and …
Role Of Hepcidin In The Diagnosis Of Sepsis And Septic Shock In Children, Osman Yeşi̇lbaş, Esra Şevketoğlu, Burcu Bursal Duramaz, Hasan Serdar Kihtir, Asuman Gedi̇kbaşi, Mey Tali̇p Petmezci̇, Canan Baydemi̇r
Role Of Hepcidin In The Diagnosis Of Sepsis And Septic Shock In Children, Osman Yeşi̇lbaş, Esra Şevketoğlu, Burcu Bursal Duramaz, Hasan Serdar Kihtir, Asuman Gedi̇kbaşi, Mey Tali̇p Petmezci̇, Canan Baydemi̇r
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study is to compare the diagnostic value of hepcidin level with the white blood cell (WBC), C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels in pediatric sepsis and septic shock. Materials and methods: A cohort of 89 individuals were divided into four groups: a healthy control group (HCG, n = 28), pediatric intensive care unit control group (PICUCG, n = 17), sepsis group (SG, n = 23), and septic shock group (SSG, n = 21). WBC, CRP, PCT, IL-6, and hepcidin levels were studied in the PICUCG, SG, and SSG, while hepcidin and IL-6 …
Serum Procalcitonin And C-Reactive Protein Kinetics As Indicators Of Treatmentoutcome In Hospitalized Patients With Community-Acquired Pneumonia, Mehmet Sezai̇ Taşbakan, Canan Gündüz, Abdullah Sayiner, Aykut Çi̇lli̇, Burcu Çelenk Karaboğa, Ayşin Şakar Coşkun, Feri̇de Durmaz Yaman, Oğuz Kilinç, Öznur Kiliç Soylar
Serum Procalcitonin And C-Reactive Protein Kinetics As Indicators Of Treatmentoutcome In Hospitalized Patients With Community-Acquired Pneumonia, Mehmet Sezai̇ Taşbakan, Canan Gündüz, Abdullah Sayiner, Aykut Çi̇lli̇, Burcu Çelenk Karaboğa, Ayşin Şakar Coşkun, Feri̇de Durmaz Yaman, Oğuz Kilinç, Öznur Kiliç Soylar
Turkish Journal of Medical Sciences
Background/aim: There has been growing interest in the use of serum procalcitonin (PCT) and C-reactive protein (CRP) in patients with community-acquired pneumonia (CAP). The aim of this study was to investigate whether an assessment of fever, leukocyte count, and serum CRP and PCT levels on admission and during follow-up (day 3) provides any information about the clinical outcome in hospitalized patients with CAP. Materials and methods: Patients with a diagnosis of CAP who were admitted to and followed at four university hospitals were evaluated retrospectively using the Turkish Thoracic Society Pneumonia Database. Results: A total of 103 hospitalized CAP patients …
Liporotein-Associated Phospholipase-A2 Can Be A Diagnostic Marker Inthe Early Stage Diagnosis Of Acute Mesenteric Ischemia, Tarik Acar, Sedat Koçak, Başar Cander, Mehmet Ergi̇n, Cesareddi̇n Di̇kmetaş
Liporotein-Associated Phospholipase-A2 Can Be A Diagnostic Marker Inthe Early Stage Diagnosis Of Acute Mesenteric Ischemia, Tarik Acar, Sedat Koçak, Başar Cander, Mehmet Ergi̇n, Cesareddi̇n Di̇kmetaş
Turkish Journal of Medical Sciences
Background/aim: The purpose of this experimental study was to investigate the role of lipoprotein-associated phospholipase-A2 (Lp-PLA2) in the diagnosis of acute mesenteric ischemia (AMI) in the early stage. Materials and methods: Twenty-seven New Zealand rabbits were randomly divided into 3 groups in this study. Blood specimens were obtained from the groups at hours 0, 1, 3, and 6. Using the blood samples drawn from all groups, Lp-PLA2 and C-reactive protein (CRP) parameters were investigated. Results: There was a significant rise in the levels of both Lp-PLA2 and CRP starting at hour 1 (P < 0.05) (hour 1; Lp-PLA2, P = 0.003) in the ischemia group. In the sham group, the levels of Lp-PLA2 and CRP started to rise at hour 3 (P < 0.05) (hour 3; Lp-PLA2, P = 0.011). At hour 6 of ischemia, the area under the ROC curve was 100%, and the cut-off value of 63.91 ng/mL revealed a sensitivity of 88% and a specificity of 100% for Lp-PLA2. Conclusion: These findings showed the role of serum Lp-PLA2 and CRP levels in the early diagnosis of AMI. Thus, further studies are needed to describe the role of Lp-PLA2 in the early diagnosis of AMI.
Oxidative Stress-Induced Dna Damage And Homocysteine Accumulation May Beinvolved In Ovarian Cancer Progression In Both Young And Old Patients, Shazia Anwer Bukhari, Kashaf Zafar, Muhammad Ibrahim Rajoka, Zubair Ibrahim, Sadia Javed, Rafshan Sadiq
Oxidative Stress-Induced Dna Damage And Homocysteine Accumulation May Beinvolved In Ovarian Cancer Progression In Both Young And Old Patients, Shazia Anwer Bukhari, Kashaf Zafar, Muhammad Ibrahim Rajoka, Zubair Ibrahim, Sadia Javed, Rafshan Sadiq
Turkish Journal of Medical Sciences
Background/aim: Biochemical, environmental, and genetic factors such as oxidative stress-induced DNA damage and homocysteine (Hcy) accumulation in the blood are involved in the development and progression of ovarian cancer. This study measured some biomarkers closely linked to the progression of ovarian cancer and also found their correlates. Materials and methods: Thirty patients were diagnosed with ovarian cancer using pelvic examination, transvaginal ultrasound, and cancer antibody (CA-125) measurement. Total oxidative stress (TOS), DNA damage, Hcy, malondialdehyde (MDA), total antioxidant status (TAS), and other biochemical parameters were determined. Results: TOS and DNA damage were positively and significantly correlated between themselves and were …
Protective Effect Of \Beta-Glucan On Acute Lung Injury Induced Bylipopolysaccharide In Rats, Meryem Iraz, Mustafa Iraz, Mukaddes Eşrefoğlu, Mehmet Şeri̇f Aydin
Protective Effect Of \Beta-Glucan On Acute Lung Injury Induced Bylipopolysaccharide In Rats, Meryem Iraz, Mustafa Iraz, Mukaddes Eşrefoğlu, Mehmet Şeri̇f Aydin
Turkish Journal of Medical Sciences
Background/aim: Lipopolysaccharide (LPS)-induced endotoxemia can cause serious organ damage such as acute lung injury and death by triggering the secretion of proinflammatory cytokines and acute-phase reactants. The goal of this study was to evaluate the effects of \beta-glucan on inflammatory mediator levels and histopathological changes in LPS-induced endotoxemia. Materials and methods: Forty-seven male Wistar albino rats were randomly allocated into four groups as follows: control group, LPS group (10 mg/kg LPS), LPS + \beta-glucan group (100 mg/kg \beta-glucan before LPS administration), and \beta-glucan group. Twelve hours after LPS administration, lung and serum samples were collected. Concentrations of IL-6, IL-8, C-reactive …
Serum Lp-Pla2: As A Novel Viewpoint In Periodontal Treatment Of Hyperlipidaemics, Özlem Fentoğlu, Fatma Yeşi̇m Kirzioğlu, Memduha Tözüm Bulut, Şi̇vge Kurgan, Havva Koçak, Recep Sütcü, Banu Kale Köroğlu, Meral Günhan
Serum Lp-Pla2: As A Novel Viewpoint In Periodontal Treatment Of Hyperlipidaemics, Özlem Fentoğlu, Fatma Yeşi̇m Kirzioğlu, Memduha Tözüm Bulut, Şi̇vge Kurgan, Havva Koçak, Recep Sütcü, Banu Kale Köroğlu, Meral Günhan
Turkish Journal of Medical Sciences
Background/aim: To evaluate the effects of periodontal treatment on serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) levels in hyperlipidaemic patients with periodontitis. Materials and methods: The study included 52 hyperlipidaemics and 28 systemically healthy controls (C) with periodontitis. Of the 52 hyperlipidaemics, 29 received a suggested diet (HD), and 23 of them were prescribed statin (HS). Clinical periodontal parameters, serum lipids, Lp-PLA2, and CRP levels were assessed at the baseline and 2 months after the completion of the nonsurgical periodontal treatment (2MPT). Serum parameters were also evaluated 1 week following the periodontal treatment (1WPT). Results: At the baseline, …
Better Marital Adjustment Is Associated With Lower Disease Activity In Early Inflammatory Arthritis, Sally Sabry Mustafa, Karl Julian Looper, Margaret Purden, Phyllis Zelkowitz, Murray Baron
Better Marital Adjustment Is Associated With Lower Disease Activity In Early Inflammatory Arthritis, Sally Sabry Mustafa, Karl Julian Looper, Margaret Purden, Phyllis Zelkowitz, Murray Baron
Turkish Journal of Medical Sciences
The aim of this study was to examine the association between marital adjustment and disease outcomes in patients with early inflammatory arthritis. Materials and methods: Patients with average disease duration of 7.66 ± 3.79 months were recruited from a larger early inflammatory arthritis registry, which recorded sociodemographic data and disease characteristics. The acute phase reactant C-reactive protein (CRP) levels were measured and disease activity was estimated using the Disease Activity Score in 28 joints (DAS28). Patient and spouse perceived marital adjustment was assessed by the Dyadic Adjustment Scale (DAS). Results: The study sample consisted of 73 patients living with their …
Comparison Of Serum Levels Of Il-6, Il-8, Tnf-Α, C Reactive Protein And Heat Shock Protein 70 In Patients With Active Or Inactive Behçet’S Disease, Remzi̇ Karadağ, Cemi̇le Koca, Yüksel Totan, Ramazan Yağci, Murat Aydin, Ayşe Serap Karadağ, Celi̇le Gülfer Akbay, Hati̇ce Meral Ekşi̇oğlu, Muhammet Ramazan Yi̇ği̇toğlu
Comparison Of Serum Levels Of Il-6, Il-8, Tnf-Α, C Reactive Protein And Heat Shock Protein 70 In Patients With Active Or Inactive Behçet’S Disease, Remzi̇ Karadağ, Cemi̇le Koca, Yüksel Totan, Ramazan Yağci, Murat Aydin, Ayşe Serap Karadağ, Celi̇le Gülfer Akbay, Hati̇ce Meral Ekşi̇oğlu, Muhammet Ramazan Yi̇ği̇toğlu
Turkish Journal of Medical Sciences
The aim of this study was to elucidate serum levels of IL-6, IL-8, TNF-\alpha, CRP, and HSP 70 in patients with active or inactive Behçet's disease. Materials and methods: The study included 50 patients who met the International Study Group criteria for Behçet's disease. Of these, 26 had active disease and 24 had inactive disease. The control group was comprised of 25 age- and sex-matched healthy participants. Serum levels of IL-6, IL-8, TNF-\alpha, CRP, and HSP 70 were measured. Results: In patients with active disease, significantly higher mean serum levels of IL-6, IL-8, TNF-\alpha, and CRP were found compared to …
Assessment Of Procalcitonin And Other Inflammatory Markers In Peritoneal Dialysis-Related Peritonitis*, Reyhan Öztürk, Gül R. Yilmaz, Cemal Bulut, Hülya Parpucu, Sami̇ Kinikli, Murat Duranay, Ali̇ Pekcan Demi̇röz
Assessment Of Procalcitonin And Other Inflammatory Markers In Peritoneal Dialysis-Related Peritonitis*, Reyhan Öztürk, Gül R. Yilmaz, Cemal Bulut, Hülya Parpucu, Sami̇ Kinikli, Murat Duranay, Ali̇ Pekcan Demi̇röz
Turkish Journal of Medical Sciences
It is demonstrated that in end-stage renal failure without an infectious pathology conventional laboratory parameters such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) or other acute-phase proteins increase non-specifically. We aimed to evaluate procalcitonin (PCT) and other inflammatory markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in patients with continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis. Materials and methods: A case-control study was conducted in a 600-bed tertiary hospital. Fifty patients with CAPD-related peritonitis constituting the study group and 50 CAPD patients without infection as the control group were included in the study between February 2006 …
Total Antioxidant Capacity And C-Reactive Protein Levels In Patients With Community-Acquired Pneumonia, Ahmet Bi̇rcan, Recep Sütçü, Müni̇re Gökirmak, Hi̇cran Hi̇çyilmaz, Ahmet Akkaya, Önder Öztürk
Total Antioxidant Capacity And C-Reactive Protein Levels In Patients With Community-Acquired Pneumonia, Ahmet Bi̇rcan, Recep Sütçü, Müni̇re Gökirmak, Hi̇cran Hi̇çyilmaz, Ahmet Akkaya, Önder Öztürk
Turkish Journal of Medical Sciences
Aims: The aim of this study was to evaluate the oxidative stress measured by serum total antioxidant capacity (TAC) and malondialdehyde (MDA) in patients with community-acquired pneumonia (CAP), and to evaluate their possible correlation with the serum C-reactive protein (CRP) and pneumonia severity index (PSI). Materials and Methods: The PSI, chest X-ray (CXR) scores, and the serum TAC, MDA, and CRP levels were determined in 67 CAP patients on admission and compared to 45 healthy controls. Results: In the whole study population, the TAC level was inversely correlated with CRP levels and WBC counts (r=-0.648, P=0.0001; r=-0.626, P=0.0001, respectively). Lower …
The Role Of Periodontal Disease On Acute Phase Proteins In Patients With Coronary Heart Disease And Diabetes, Gonca Çayir Keleş, Burcu Özkan Çeti̇nkaya, Selen Burçak Şi̇mşek, Di̇yar Köprülü, Hakki Kahraman
The Role Of Periodontal Disease On Acute Phase Proteins In Patients With Coronary Heart Disease And Diabetes, Gonca Çayir Keleş, Burcu Özkan Çeti̇nkaya, Selen Burçak Şi̇mşek, Di̇yar Köprülü, Hakki Kahraman
Turkish Journal of Medical Sciences
Aims: Chronic infections such as periodontal disease (PD) have been suggested to be a risk factor for coronary heart disease (CHD). Elevated levels of acute phase proteins are associated with increased risk for cardiovascular events in both healthy individuals and patients with known CHD. This study aimed to investigate the role of PD on C-reactive protein (CRP) and fibrinogen levels in patients with either CHD or type 2 diabetes. Materials and Methods: 80 subjects were evaluated in four groups: individuals with CHD+PD (group 1; n: 20), individuals with type 2 diabetes+PD (group 2; n: 20), individuals with PD without any …
Plasma Procalcitonin Levels In Chronic Haemodialysis Patients, H. Handan Akbulut, İlhami̇ Çeli̇k, Mehmet Özden, Ayhan Doğukan, Vedat Bulut
Plasma Procalcitonin Levels In Chronic Haemodialysis Patients, H. Handan Akbulut, İlhami̇ Çeli̇k, Mehmet Özden, Ayhan Doğukan, Vedat Bulut
Turkish Journal of Medical Sciences
The objective of our study was to assess procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in end-stage renal disease (ESRD) patients undergoing haemodialysis sessions and the effect of intermittent haemodialysis on PCT levels. We measured plasma PCT and CRP levels in 43 ESRD patients without evidence of systemic infection at the beginning of haemodialysis and 4 hours later. Control group consisted of 40 volunteers with no complaints. Venous blood samples were collected from the patient before and after hemodialysis and the control groups. PCT was assayed by immunoluminometry. The mean plasma concentration of PCT (2.13 ± 0.7 ng/mL) and …