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Full-Text Articles in Medicine and Health Sciences
Different Roles Of Endothelial Cell-Derived Fibronectin And Plasma Fibronectin In Endothelial Dysfunction, Xiaoxin Luo, Weixiong Jian
Different Roles Of Endothelial Cell-Derived Fibronectin And Plasma Fibronectin In Endothelial Dysfunction, Xiaoxin Luo, Weixiong Jian
Turkish Journal of Medical Sciences
MDABackground/ aim: Atherosclerosis is significantly influenced by endothelial cell activation and dysfunction. Studies have demonstrated the substantial presence of fibronectin (Fn) within atherosclerotic plaques, promoting endothelial inflammation and activation. However, cellular Fn (cFn) secreted by various cell types, including endothelial cells and smooth muscle cells, and plasma Fn (pFn) produced by hepatocytes. They are distinct forms of Fn that differ in both structure and function. The specific contribution of different types of Fn in promoting endothelial cell activation and dysfunction remain uncertain. Therefore, this study aimed to investigate the respective roles of pFn and endothelial cell-derived Fn (FnEC) in promoting …
A Novel Marker Relationship Between Carotid Intima-Media Thickness And Disease Activity Score-28 In Patients With Rheumatoid Arthritis: Human Endothelial Cell-Specific Molecule-1, Göksel Tuzcu, Ali̇ Uğur Uslu, Ayça Tuzcu, Rabi̇a Aydoğan Baykara, Ahmet Omma, Adem Küçük
A Novel Marker Relationship Between Carotid Intima-Media Thickness And Disease Activity Score-28 In Patients With Rheumatoid Arthritis: Human Endothelial Cell-Specific Molecule-1, Göksel Tuzcu, Ali̇ Uğur Uslu, Ayça Tuzcu, Rabi̇a Aydoğan Baykara, Ahmet Omma, Adem Küçük
Turkish Journal of Medical Sciences
Background/aim: Human endothelial cell-specific molecule-1 (endocan) is a marker of vascular endothelial dysfunction that may be used in the evaluation of inflammatory-associated atherosclerotic lesions. Endocan may be a marker for the evaluation of atherosclerosis and disease activity in rheumatoid arthritis (RA) patients.Materials and methods: We included 39 RA patients assessed according to the American College of Rheumatology/European League Against Rheumatology 2010 diagnostic criteria and recruited 30 age- and sex-matching healthy subjects for the control group.Results: Endocan values were 14.11 ± 3.27 for the RA patients and 12.10 ± 2.92 for the controls. The endocan values of the patients were significantly …
Relationship Between Plasma Ykl-40 Levels And Endothelial Dysfunction In Chronic Kidney Disease, Gül Sema Yildiran Keski̇n, Özant Helvaci, Çağri Yayla, Özge Tuğçe Paşaoğlu, Çağlar Keski̇n, Seli̇m Turgay Arinsoy, Ülver Deri̇ci̇
Relationship Between Plasma Ykl-40 Levels And Endothelial Dysfunction In Chronic Kidney Disease, Gül Sema Yildiran Keski̇n, Özant Helvaci, Çağri Yayla, Özge Tuğçe Paşaoğlu, Çağlar Keski̇n, Seli̇m Turgay Arinsoy, Ülver Deri̇ci̇
Turkish Journal of Medical Sciences
We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery. Results: YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). …
Serum Fetuin-A Is Associated With The Components Of Miac(Malnutrition, Inflammation, Atherosclerosis, Calcification) Syndrome In Different Stages, Rüya Mutluay, Ceyla Konca Değerteki̇n, Emel Işiktaş Sayilar, Ülver Deri̇ci̇, Serap Gülteki̇n, Sevi̇m Gönen, Seli̇m Turgay Arinsoy, Mahmut Şükrü Si̇ndel
Serum Fetuin-A Is Associated With The Components Of Miac(Malnutrition, Inflammation, Atherosclerosis, Calcification) Syndrome In Different Stages, Rüya Mutluay, Ceyla Konca Değerteki̇n, Emel Işiktaş Sayilar, Ülver Deri̇ci̇, Serap Gülteki̇n, Sevi̇m Gönen, Seli̇m Turgay Arinsoy, Mahmut Şükrü Si̇ndel
Turkish Journal of Medical Sciences
Background/aim: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic kidney disease (CKD). Materials and methods: CKD patients were sampled for calcium-phosphate parameters and nutritional and inflammatory markers [highly sensitive C-reactive protein (hs-CRP)], and serum fetuin-A levels. Intima-media thicknesses of the common carotid arteries (CIMT) were measured. Peripheral artery calcification scores were obtained.Results: A total of 238 patients were included in the study. Fetuin-A levels in patients with end-stage renal disease were significantly lower …
Serum Adma, Endothelial Dysfunction, And Atherosclerosis In Hypervolemichemodialysis Patients, İbrahi̇m Doğan, Bariş Eser, Sultan Özkurt, Özlem Yayar, Bülent Özgür, Hüseyi̇n Kayadi̇bi̇, Tolga Doğan, Ahmet Musmul, Mehmet Soydan
Serum Adma, Endothelial Dysfunction, And Atherosclerosis In Hypervolemichemodialysis Patients, İbrahi̇m Doğan, Bariş Eser, Sultan Özkurt, Özlem Yayar, Bülent Özgür, Hüseyi̇n Kayadi̇bi̇, Tolga Doğan, Ahmet Musmul, Mehmet Soydan
Turkish Journal of Medical Sciences
Background/aim: Asymmetric dimethyl arginine (ADMA) is a strong predictor of cardiovascular disease and mortality in patients under hemodialysis treatment. We aimed to investigate the relationship among volume status, endothelial dysfunction, and ADMA in hemodialysis patients. Materials and methods: A total of 120 patients with a history of hemodialysis treatment were included. ADMA and CRP were measured. Echocardiographic evaluation and carotid artery intima-media thickness (CIMT) measurements were performed. Patients were divided into two groups according to clinical evaluation, ultrafiltration rate, vena cava inferior diameter (VCI), and cardiothoracic index (CTI); the two groups were hypervolemic and normovolemic. Results: The hypervolemic group included …
Distribution Of Ldl Subgroups In Patients With Hyperlipidemia, Ebru Taylan, Emi̇ne Pinar Tuncel
Distribution Of Ldl Subgroups In Patients With Hyperlipidemia, Ebru Taylan, Emi̇ne Pinar Tuncel
Turkish Journal of Medical Sciences
Background/aim: Low-density lipoproteins (LDLs) have been shown to be a major risk factor for coronary artery disease. Multiple distinct subspecies have been identified among LDL particles on the basis of differences in size, density, and chemical composition. Particles with a diameter of
The Relation Between Serum Cathepsin D Level And Carotid Intima-Media Thickness In Nondiabetic Hypertensive Patients, Ni̇hal Özkayar, Fatma Akyel, Ayşe Nurdan Barça, Serhan Vahi̇t Pi̇şki̇npaşa, Turan Turhan, İhsan Ateş, Fati̇h Dede
The Relation Between Serum Cathepsin D Level And Carotid Intima-Media Thickness In Nondiabetic Hypertensive Patients, Ni̇hal Özkayar, Fatma Akyel, Ayşe Nurdan Barça, Serhan Vahi̇t Pi̇şki̇npaşa, Turan Turhan, İhsan Ateş, Fati̇h Dede
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate the relation between carotid intima-media thickness (CIMT) and serum cathepsin D level in hypertensive patients. Materials and methods: This was a cross-sectional study of 74 hypertensive patients (22 males and 52 females, with a mean age of 51.86 ± 11.75 years). Serum levels of cathepsin D were measured with an enzyme-linked immunosorbent assay. CIMT measurements were taken from 3 different points: right and left common carotid arteries, bifurcation, and the first 2 cm of the internal carotid artery. Mean CIMT was calculated by averaging the measurements taken 3 times from each carotid artery. Results: Mean …
Osteoprotegerin As A Marker Of Atherosclerosis In Type 1 And Type 2 Diabetic Patients, Çi̇ğdem Alkaç, Burak Alkaç, Feray Akbaş, Hale Aral, Yeşi̇m Karagöz, Esma Güldal Altunoğlu
Osteoprotegerin As A Marker Of Atherosclerosis In Type 1 And Type 2 Diabetic Patients, Çi̇ğdem Alkaç, Burak Alkaç, Feray Akbaş, Hale Aral, Yeşi̇m Karagöz, Esma Güldal Altunoğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the availability of osteoprotegerin (OPG) as a marker of atherosclerosis and compare serum OPG levels with ankle-brachial index (ABI) in diabetic patients. Materials and methods: A total of 31 type 1 and 31 type 2 diabetic patients without macrovascular complications and 20 healthy volunteers were included. Serum OPG levels and ABI were measured. Results: The duration of diabetes was significantly higher in type 1 diabetics than in type 2, although there was no significant difference between mean HbA1c levels. There was a weak and inverse correlation between OPG and atherosclerosis in …
Asymmetric Dimethyl Arginine Levels In Chronic Hemodialysis Patients, Aydin Çi̇fci̇, Sali̇h İnal, Coşkun Kaya
Asymmetric Dimethyl Arginine Levels In Chronic Hemodialysis Patients, Aydin Çi̇fci̇, Sali̇h İnal, Coşkun Kaya
Turkish Journal of Medical Sciences
To investigate serum asymmetric dimethyl arginine (ADMA) levels in maintenance hemodialysis (HD) patients and to assess their potential correlations with C-reactive protein (CRP), albumin, and cholesterol levels as the established cardiovascular and nutritional parameters. Materials and methods: Forty-nine patients on maintenance HD treatment and 22 healthy volunteers with similar age and sex characteristics were recruited into the study. Serum albumin, CRP, creatinine, calcium, phosphate, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, hemoglobin, white blood cell counts, and serum ADMA levels were measured. Results: HD patients had significantly higher ADMA levels compared with healthy controls (0.51 ± 0.25 …
Prevalence Of Carotid Artery Calcification On Panoramic Radiographs In Patients With Renal Stones, İhsan Üstün, Mehmet İnci̇, Abdullah Demi̇rtaş, Yildiray Şi̇şman, Cumali̇ Gökçe, Eli̇f Tarim Ertaş
Prevalence Of Carotid Artery Calcification On Panoramic Radiographs In Patients With Renal Stones, İhsan Üstün, Mehmet İnci̇, Abdullah Demi̇rtaş, Yildiray Şi̇şman, Cumali̇ Gökçe, Eli̇f Tarim Ertaş
Turkish Journal of Medical Sciences
To determine the prevalence of carotid artery calcification (CAC) detected in routine dental radiography (PRs) in patients with kidney stones (KSs) and to investigate the relationship between CAC-atherosclerosis and KSs. Materials and methods: A total of 108 patients with renal stones were included in the present study. A history of renal colic, with confirmed hematuria and voiding of the calculus, radiographic evidence of KSs, or previous surgical and endoscopic removal of KSs, was used to define the nephrolithiasis. KS patients were evaluated by PR in terms of the presence of CAC. Subjects with either unilateral or bilateral CAC on these …
Relation Of Total Homocysteine Level With Metabolic And Anthropometric Variables In Obese Children And Adolescents, Ayhan Abaci, Ahmet Zülfi̇kar Akelma, Osman Özdemi̇r, Şami̇l Hizli, Cem Hasan Razi, Kadi̇r Okhan Akin
Relation Of Total Homocysteine Level With Metabolic And Anthropometric Variables In Obese Children And Adolescents, Ayhan Abaci, Ahmet Zülfi̇kar Akelma, Osman Özdemi̇r, Şami̇l Hizli, Cem Hasan Razi, Kadi̇r Okhan Akin
Turkish Journal of Medical Sciences
To evaluate the total homocysteine (tHcy) level, a risk factor for atherosclerosis, atherothrombosis, and insulin resistance, for sex and pubertal state differences in obese children. Its relationship with metabolic and anthropometric parameters was also investigated. Materials and methods: The study involved obese children with a body mass index (BMI) above the 95th percentile who presented with the complaint of excessive weight gain, and healthy children with a BMI below the 85th percentile. Results: The study included 100 obese (mean age: 10.2 ± 2.7 years) and 71 healthy nonobese (mean age: 10.9 ± 2.6) children. A comparison of the data from …
Plasma Ldl Subtype Distribution In Patients With Or Without Coronary Stenosis, Yeşi̇m Er Öztaş, Çağdaş Özdöl, Levent Karaca
Plasma Ldl Subtype Distribution In Patients With Or Without Coronary Stenosis, Yeşi̇m Er Öztaş, Çağdaş Özdöl, Levent Karaca
Turkish Journal of Medical Sciences
Plasma low density lipoprotein (LDL) had 3 subtypes according to its separation by polyacrylamide gradient gel electrophoresis. Of these, the small, dense (Sd) LDL particles have been accepted as an emerging cardiovascular risk factor. This study was conducted to assess the LDL subtypes in a group of patients undergoing coronary angiography. Materials and methods: The study involved 56 patients—36 of whom had at least 1 vessel stenosed (stenosis group)—and 20 patients who had no stenosis (non-stenosis group). LDL subtypes were determined according to their migration pattern after non-denaturing gradient gel electrophoresis. Total cholesterol, LDL and high density lipoprotein (HDL), and …
An Investigation Of Changes In Ocular Blood Flow In Rabbits With Long-Term Hyperhomocysteinemia Using Color Doppler Ultrasonography, Fi̇gen Nari̇n, Abdulhaki̇m Coşkun, Nazmi̇ Nari̇n, Ali̇ Baykan, Sertaç Hanedan Onan, Abdulkeri̇m Coşkun, Muammer Hakan Poyrazoğlu, Ruşen Erez
An Investigation Of Changes In Ocular Blood Flow In Rabbits With Long-Term Hyperhomocysteinemia Using Color Doppler Ultrasonography, Fi̇gen Nari̇n, Abdulhaki̇m Coşkun, Nazmi̇ Nari̇n, Ali̇ Baykan, Sertaç Hanedan Onan, Abdulkeri̇m Coşkun, Muammer Hakan Poyrazoğlu, Ruşen Erez
Turkish Journal of Medical Sciences
Hyperhomocysteinemia was induced in rabbits using methionine. Ocular blood flow changes were examined by color Doppler ultrasonography (CDU). Materials and methods: Fifty New Zealand rabbits were divided into 5 groups. Groups 1-4 received one of the following chemicals: methionine only, methionine plus vitamin B6, methionine plus vitamin B12, or methionine plus folic acid. Controls received no chemicals. Serum homocysteine levels were measured on treatment days 1 and 60. Orbital vessels were examined by CDU on day 60. Results: In the 4 study groups, homocysteine levels were significantly elevated on day 60 compared to the levels on day 1 (P < 0.05). Elevations of homocysteine levels in group 1 were greater than those of groups 2 and 4 on day 60 (P < 0.05). When results of ocular blood flow changes were compared, no statistically significant difference was found based on flow velocities in the ophthalmic artery. Measurements from the ciliary artery revealed a statistically significant decrease in flow velocity in the study groups (P < 0.05). Conclusion: Using CDU, we found that flow velocities in the ciliary artery were decreased. This condition is attributed to atherosclerotic and thromboembolic alterations of the ocular vessels due to hyperhomocysteinemia.
Evaluation Of The Performance Of A Carotid Subclavian By-Pass As A Source For Internal Thoracic Artery, İbrahi̇m Duvan, Alper Gürbüz, Meti̇n Demi̇rci̇n
Evaluation Of The Performance Of A Carotid Subclavian By-Pass As A Source For Internal Thoracic Artery, İbrahi̇m Duvan, Alper Gürbüz, Meti̇n Demi̇rci̇n
Turkish Journal of Medical Sciences
The concomitance of atherosclerotic subclavian occlusive lesion with coronary artery disease has an extraordinary importance in coronary artery bypass surgery. The development of a lesion in the subclavian artery proximal to the internal thoracic artery (ITA) before or after coronary artery bypass graft (CABG) by ITA can result with the coronary-subclavian steal syndrome and myocardial ischemia may occur. It is pretty vital to be aware of the presence of the subclavian occlusive lesion in patients undergoing CABG. We present in this paper an atherosclerotic case that had a concomitant brachiocephalic and coronary artery disease. He had both carotid and subclavian …
Homocysteine Levels And Other Risk Factors In Coronary Heart Disease, Gi̇ray Bozkaya, Aydan Çavuşoğlu, Si̇bel Bi̇lgi̇li̇, Baysal Karaca, Ercüment Cengi̇z, Oktay Bi̇lgi̇r
Homocysteine Levels And Other Risk Factors In Coronary Heart Disease, Gi̇ray Bozkaya, Aydan Çavuşoğlu, Si̇bel Bi̇lgi̇li̇, Baysal Karaca, Ercüment Cengi̇z, Oktay Bi̇lgi̇r
Turkish Journal of Medical Sciences
Many risk factors for coronary heart disease (CHD) have been reported to date. Recently, it has been shown that elevations in homocysteine (Hcy) levels may contribute to the development of coronary heart diseases. In this study, our aim was to determine the relation of Hcy levels and other risk factors in CHD. Serum Hcy, lipoprotein(a) [Lp(a)], C-reactive protein (CRP), fibrinogen, cholesterol, triglyceride, HDL and LDL levels were measured in 51 male patients, diagnosed with CHD with negative T elevations in electrocardiograms, and in 20 healthy males. Hcy was determined in serum samples with Fluorescence Polarization Immunoassay (FPIA) on Abbott IMx. …
The Effects Of Insulin On Serum Levels Of Apo A-I Containing Lipoprotein Particles In Syndrome X Patients With Coronary Heart Disease, Meti̇n Yildirimkaya, Cumhur Kilinç, Mustafa Özkan, Kurtuluş Yilmaz, Yavuz Nari̇n
The Effects Of Insulin On Serum Levels Of Apo A-I Containing Lipoprotein Particles In Syndrome X Patients With Coronary Heart Disease, Meti̇n Yildirimkaya, Cumhur Kilinç, Mustafa Özkan, Kurtuluş Yilmaz, Yavuz Nari̇n
Turkish Journal of Medical Sciences
Syndrome X consists of low serum high density lipoprotein-cholesterol (HDL-C), raised serum triglyceride, glucose intolerance, increased blood pressure, abdominal obesity and insulin resistance which is associated with increased risk of coronary heart disease (CHD). Apolipoprotein (apo) A-I containing lipoprotein particles, lipoprotein A-I (Lp A-I) and lipoprotein A-I:A-II (Lp A-I:A-II.) may have different metabolic functions. The purpose of this study was to evaluate the relationship between insulin and apo A-I containing lipoproteins in syndrome X patients with or without CHD. We selected 38 male patients with syndrome X and divided into two groups: The one with CHD (n=21) and the other …