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Full-Text Articles in Medicine and Health Sciences
Effects Of Cinnamic Acid On Complications Of Diabetes, Hati̇ce Gül Anlar, Merve Bacanli, Tuğbagül Çal, Sevtap Aydin, Nuray Ari, Ülkü Ündeğer Bucurgat, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran
Effects Of Cinnamic Acid On Complications Of Diabetes, Hati̇ce Gül Anlar, Merve Bacanli, Tuğbagül Çal, Sevtap Aydin, Nuray Ari, Ülkü Ündeğer Bucurgat, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran
Turkish Journal of Medical Sciences
Background/aim: Diabetes mellitus (DM) is a major health problem worldwide. Cinnamic acid (CA) and its derivatives are synthesized in plants and increasing attention has been given to them in recent years due to the high number of beneficial health properties attributed to their consumption. The aim of this study was to investigate the effects of CA on streptozotocin-induced diabetes in Wistar albino rats. Materials and methods: DNA damage was evaluated in the blood, liver, and kidney cells of rats by the alkaline comet assay. Oxidative stress parameters such as catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidase activities and …
Investigation Of The Relationship Between Oxidative Stress Andscube1 Levels In High Fat Diet-Induced Obese Rats, Akin Bodur, Cemi̇l Kahraman, Di̇ler Us Altay, Taghi Ahmadi Rendi, Ahmet Menteşe, Ahmet Alver
Investigation Of The Relationship Between Oxidative Stress Andscube1 Levels In High Fat Diet-Induced Obese Rats, Akin Bodur, Cemi̇l Kahraman, Di̇ler Us Altay, Taghi Ahmadi Rendi, Ahmet Menteşe, Ahmet Alver
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate signal peptide-Cub-EGF domain-containing protein 1 (SCUBE1) levels and oxidative stress (OS) in a high fat diet (HFD)-induced obese rat model. Materials and methods: Fourteen rats were randomly divided into two groups. Group 1, the control group, was given a standard diet (10% calories of fat) and Group 2, the obese group, was given a HFD (60% calories of fat), both for 70 days. Rats were then sacrificed and serum samples were collected. Serum glucose and triglyceride concentrations were determined using an autoanalyzer. Serum SCUBE1, adiponectin, and plasminogen activator inhibitor-1 levels were determined using an …
Dynamic Thiol-Disulfide Homeostasis Is Disturbed In Hepatitis B Virus-Related Chronichepatitis And Liver Cirrhosis, Ramazan Dertli̇, Muharrem Keski̇n, Murat Biyik, Hüseyi̇n Ataseven, Hakki Polat, Ali̇ Demi̇r, Pembe Oltulu, Sali̇m Neşeli̇oğlu, Özcan Erel, Mehmet Asil
Dynamic Thiol-Disulfide Homeostasis Is Disturbed In Hepatitis B Virus-Related Chronichepatitis And Liver Cirrhosis, Ramazan Dertli̇, Muharrem Keski̇n, Murat Biyik, Hüseyi̇n Ataseven, Hakki Polat, Ali̇ Demi̇r, Pembe Oltulu, Sali̇m Neşeli̇oğlu, Özcan Erel, Mehmet Asil
Turkish Journal of Medical Sciences
Background/aim: Thiol-disulfide homeostasis is an important antioxidant defense mechanism. This study was conducted to investigate dynamic thiol-disulfide homeostasis in patients with hepatitis B virus-related chronic hepatitis and liver cirrhosis. Materials and methods: Seventy-one treatment-naive patients with chronic hepatitis B (CHB), 50 patients with hepatitis B virusassociated liver cirrhosis, and 45 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentrations were measured using an automated method. Results: Mean serum total thiol concentrations in the control, CHB, and cirrhosis groups were 481.64 ± 37.87 µmol/L, 438.50 ± 71.35 µmol/L, and 358.07 ± 80.47 µmol/L, …