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Maternal Protein Restriction During Perinatal Life Affects Lung Mechanics And The Surfactant System During Early Postnatal Life In Female Rats., Reza Khazaee, Lynda A Mccaig, Cory Yamashita, Daniel B Hardy, Ruud A W Veldhuizen
Maternal Protein Restriction During Perinatal Life Affects Lung Mechanics And The Surfactant System During Early Postnatal Life In Female Rats., Reza Khazaee, Lynda A Mccaig, Cory Yamashita, Daniel B Hardy, Ruud A W Veldhuizen
Physiology and Pharmacology Publications
Limited information is available on how fetal growth retardation (FGR) affects the lung in the neonatal period in males and females. This led us to test the hypothesis that FGR alters lung mechanics and the surfactant system during the neonatal period. To test this hypothesis a model of FGR was utilized in which pregnant rat dams were fed a low protein diet during both the gestation and lactation period. We subsequently analyzed lung mechanics using a FlexiVent ventilator in male and female pups at postnatal day 7 and 21. Lung lavage material was obtained at postnatal day 1, 7 and …