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Loma Linda University Electronic Theses, Dissertations & Projects
Immune cells; Monocytes; Linker Histone Proteins; Chronic Adipose Tissue Inflammation;
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Palmitic Acid Activation Of Dendritic Cells: Implications For Type 2 Diabetes, Dequina Angelina Nicholas
Palmitic Acid Activation Of Dendritic Cells: Implications For Type 2 Diabetes, Dequina Angelina Nicholas
Loma Linda University Electronic Theses, Dissertations & Projects
Infiltration of immune cells into visceral adipose tissue is observed in type 2 diabetes development. Monocytes are recruited to obese visceral adipose tissue in large numbers and retain the ability to differentiate into dendritic cells, important antigen presenting cells in the immune system. Differentiation of monocytes into dendritic cells likely accounts for the increased number of dendritic cells observed in the adipose tissue of type 2 diabetic patients. We have demonstrated this differentiation process is regulated in part by a major reduction of linker histone proteins. In adipose tissue, dendritic cells are exposed to high levels of saturated fatty acids. …