Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Adenovirus (1)
- Adipocytes (1)
- Antiretroviral treatment (1)
- Assisted Reproductive Technologies (1)
- CXCL5 (1)
-
- Cancer therapy (1)
- Cardiovascular disease risk (1)
- Conservation (1)
- DBC1 (1)
- Endothelial senescence (1)
- Extinction (1)
- G9a (1)
- GLP (1)
- Gene expression (1)
- HIV (1)
- Lipolysis (1)
- MRSA (1)
- Mitochondrial dysfunction (1)
- NLRP6 (1)
- Oncolytic virology (1)
- Oncolytic virus (1)
- Pneumonia (1)
- Reproduction (1)
- Reptiles (1)
- Sepsis (1)
Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Characterizing The Roles Of Nuclear Proteins Dbc1, G9a, And Glp In Adipocyte Function And Metabolic Health, Ashley Ann Able
Characterizing The Roles Of Nuclear Proteins Dbc1, G9a, And Glp In Adipocyte Function And Metabolic Health, Ashley Ann Able
LSU Doctoral Dissertations
Obesity is a metabolic disorder characterized by excess energy storage in adipose tissue and it increases the risk for Type 2 diabetes. Impaired or altered adipocyte function during obesity can contribute to metabolic dysfunction. DBC1 (deleted in breast cancer 1) and EHMTs 1 and 2 (euchromatic histone lysine methyltransferases 1 and 2) have been shown to have a role in fat cell development and function. DBC1 is typically localized in the nucleus and can regulate a variety of epigenetic modifiers, transcription factors, and nuclear receptors. EHMTs 1 and 2, also known respectively as GLP and G9a, were initially classified as …
Nlrp6 In Gram-Positive Pneumonia And Sepsis, Laxman Ghimire
Nlrp6 In Gram-Positive Pneumonia And Sepsis, Laxman Ghimire
LSU Doctoral Dissertations
Acute lower respiratory infections (pneumonia) and pneumonia-derived sepsis are among the leading causes of death in the world causing 7.8 million deaths annually. In this regard, Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in the US and implicated for causing high mortality-associated necrotizing pneumonia and aggravating viral pneumonia with superinfection. Additionally, sepsis is the 7th leading cause of death among newborns in the US and is responsible for more than 750,000 hospitalization cases every year. Although there is a plethora of research in both pneumonia and sepsis, the detailed pathophysiology still remains elusive. Understanding the host defense mechanism will help …
Generation Of An Oncolytic Adenovirus Targeting The Cxcr4 And Cxcr7 Chemokine Receptors In Breast Cancer, Samia Melissa O'Bryan
Generation Of An Oncolytic Adenovirus Targeting The Cxcr4 And Cxcr7 Chemokine Receptors In Breast Cancer, Samia Melissa O'Bryan
LSU Doctoral Dissertations
Breast cancer is the most diagnosed cancer in women under 60 and the second most diagnosed cancer in women over 60. While treatments for localized breast cancer are quite successful with high survival rates at 99%, advanced breast cancer remains hard to treat with a nearly 75% decrease in survival. Current treatments are inefficient at treating advanced stages of breast cancer, and thus, new therapies are sorely needed to address the complexity of advanced stage breast cancer. The ideal therapy would be capable of systemic administration, targets cancer cells and spares normal tissue. Oncolytic adenovirus is an ideal therapeutic vector …
Chronic Nucleoside Reverse Transcriptase Inhibitors Disrupt Mitochondrial Homeostasis And Promote Premature Endothelial Senescence, Yi-Fan Chen
LSU Doctoral Dissertations
Combination antiretroviral therapy (cART) has been hugely successful in reducing the mortality associated with human immunodeficiency virus (HIV) infection, resulting in a growing population of people living with HIV (PLWH). Since PLWH now have a longer life expectancy, chronic comorbidities have become the focus of the clinical management of HIV. For example, cardiovascular complications are now one of the most prevalent causes of death in PLWH. Nucleoside reverse transcriptase inhibitors (NRTIs) are the backbone of cART, and two NRTIs are typically used in combination with one drug from another drug class, such as a non-NRTI, a protease inhibitor or an …
Can Assisted Reproductive Technologies Help Conserve 300 Million Years Of Evolution? A First Attempt At Developing These Technologies For Male Reptiles, Sean M. Perry
LSU Doctoral Dissertations
Biodiversity loss is the most critical environmental problem threatening ecosystem, animal, and human health today. Increases in extinction rates have been observed over the past 50 years, with reptile losses occurring twelve times faster than traditional extinction rates. This demonstrated biodiversity loss is secondary to climate change, habitat destruction, infectious disease, invasive species, poaching, and unsustainable trade. Approximately 20% of all reptiles are threatened with extinction and population declines are approaching rates similar to the current amphibian extinction crisis. Preventing the extinction of reptiles will require humans to acknowledge these losses and develop plans to preserve these evolutionary sentinel species. …