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Full-Text Articles in Medicine and Health Sciences
Distributed Task Related Bold Signal During Auditory Sub-Second Timing, Yuriy Bronshteyn
Distributed Task Related Bold Signal During Auditory Sub-Second Timing, Yuriy Bronshteyn
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The brain's input/output functions depend heavily on temporal processing. We sought to identify regions of the brain active in task performance during temporal discrimination of a sub-second auditory interval. We presented ten subjects with 40 paired tones and asked them to judge whether these comparison intervals were longer or shorter than a 100 ms standard. We then localized correlations between the Blood Oxygenation Level Dependent signal and task performance across subjects using event-related functional magnetic resonance imaging. We saw no task-related frontal cortex activation and significant activation of traditional auditory areas. Auditory regions included the bilateral superior and middle temporal …
Role Of Cytoskeletal Dynamics In Platelet Arf6 Activation, Brett Taylor Begley
Role Of Cytoskeletal Dynamics In Platelet Arf6 Activation, Brett Taylor Begley
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Platelets undergo morphological changes upon activation, such as shape change and aggregation. These changes are known to be the result of actin remodeling, whereas the role of microtubule remodeling has been controversial. The objective of this study was to re-examine the role of actin and microtubule dynamics in platelet function. We used aggregometry to measure the effect of cytoskeletal inhibitors on platelet shape change, aggregation, and dense core release. Microtubule assembly was found to have no role in platelet function, because treatment with vinblastine or nocodazole had no effect on shape change, aggregation, or secretion. Microtubule disassembly was necessary for …
P40: The Missing Link Between Autophagy And Cancer?, Mittul Patel
P40: The Missing Link Between Autophagy And Cancer?, Mittul Patel
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No abstract provided.
Diurnal Variations Of Genes Contributing To Sodium And Potassium Cardiac Currents, Parvathi Nataraj
Diurnal Variations Of Genes Contributing To Sodium And Potassium Cardiac Currents, Parvathi Nataraj
Kaleidoscope
No abstract provided.
The Role Of Oxidative Stress In Alzheimer's Disease, Robin Petroze
The Role Of Oxidative Stress In Alzheimer's Disease, Robin Petroze
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Over four million individuals in the United States currently suffer from Alzheimer's disease (AD), a devastating disorder of progressive dementia. Within the next several decades, AD is expected to affect over 22 million people globally. AD can only be definitively diagnosed by postmortem examination. Thus, investigation into the specific pathogenesis of neuronal degeneration and death in AD on a biochemical level is essential for both earlier diagnosis and potential treatment and prevention options. Overproduction of amyloid [3-peptide (A[3) in the brain leads to both free radical oxidative stress and toxicity to neurons in AD. My undergraduate biochemical studies with regard …