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Role Of 4-1bb Ligand In Costimulation Of T Lymphocyte Growth And Its Upregulation On M12 B Lymphomas By Camp, M. A. Debenedette, N. R. Chu, K. E. Pollok, J. Hurtado, William F. Wade, Byoung S. Kwon, Tania H. Watts

Dartmouth Scholarship

K46J B lymphomas express a T cell costimulatory activity that is not inhibited by CTLA-4Ig, anti-B7-1, anti-B7-2, anti-intercellular adhesion molecule 1 or antibodies to heat stable antigen. In this paper we report that this costimulatory activity is mediated at least in part by 4-1BB ligand, a member of the tumor necrosis factor (TNF) gene family that binds to 4-1BB, a T cell activation antigen with homology to the TNF/nerve growth factor receptor family. A fusion protein between 4-1BB and alkaline phosphatase (4-1BB-AP) blocks T cell activation by K46J lymphomas in both an antigen-specific system and with polyclonally (anti-CD3) activated T …