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Full-Text Articles in Medicine and Health Sciences
Development Of A Novel Mathematical Model That Explains Sars-Cov-2 Infection Dynamics In Caco-2 Cells, Vladimir Staroverov, Stepan Nersisyan, Alexei Galatenko, Dmitriy Alekseev, Sofya Lukashevich, Fedor Ployakov, Nikita Anisimov, Alexander Tonevitsky
Development Of A Novel Mathematical Model That Explains Sars-Cov-2 Infection Dynamics In Caco-2 Cells, Vladimir Staroverov, Stepan Nersisyan, Alexei Galatenko, Dmitriy Alekseev, Sofya Lukashevich, Fedor Ployakov, Nikita Anisimov, Alexander Tonevitsky
COVID-19 Papers, Posters, and Presentations
Mathematical modeling is widely used to study within-host viral dynamics. However, to the best of our knowledge, for the case of SARS-CoV-2 such analyses were mainly conducted with the use of viral load data and for the wild type (WT) variant of the virus. In addition, only few studies analyzed models for in vitro data, which are less noisy and more reproducible. In this work we collected multiple data types for SARS-CoV-2-infected Caco-2 cell lines, including infectious virus titers, measurements of intracellular viral RNA, cell viability data and percentage of infected cells for the WT and Delta variants. We showed …