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A Pseudo Non-Cartesian Pulse Sequence For Hyperpolarized Xenon-129 Gas Mri Of Rodent Lungs At Low Magnetic Field Strength, Krzysztof Wawrzyn

Electronic Thesis and Dissertation Repository

Background: Early diagnosis of radiation-induced lung injury (RILI) following radiation therapy is critical for prevention of permanent lung damage. Pulmonary imaging using magnetic resonance imaging (MRI) of the apparent diffusion coefficient (ADC) of hyperpolarized xenon (¹²⁹Xe) gas shows promise for early measurement of RILI.

Methods: An ultra-short echo time imaging sequence based on a pseudo-Cartesian k-space trajectory, known as Sectoral, is implemented at low magnetic field (0.07 T) for efficient use of the non-renewable magnetization of hyperpolarized ¹²⁹Xe gas. A pilot study was performed to demonstrate the feasibility of ADC mapping using the Sectoral sequence …