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Metabolic Correlates In Spinal Cord Compression Measured By Magnetic Resonance Spectroscopy In The Motor And Sensory Cortices, Sandy Goncalves
Metabolic Correlates In Spinal Cord Compression Measured By Magnetic Resonance Spectroscopy In The Motor And Sensory Cortices, Sandy Goncalves
Electronic Thesis and Dissertation Repository
Surgical outcome for patients suffering from cervical myelopathy (CM) is unpredictable with varying motor and sensory symptom recovery. Previous in-vivo magnetic resonance spectroscopy (MRS) studies of patients surgically treated for CM have demonstrated decreased N-acetylaspartate (NAA)/creatine levels in the motor cortex indicating reduced neuronal function. The goal of this thesis was to determine whether absolute NAA changes in the motor and sensory cortices mirror the pattern of motor and sensory functional change observed in patients post surgical treatment.
MRS data were acquired on a 3.0 Tesla Siemens MRI along with clinical outcome measures at baseline, 6-weeks and 6-months post-surgery. …