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Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Medical Sciences

Western University

2015 Undergraduate Awards

2015

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Expression Of Hiv-1 Gag And Env Genes Using The Vesicular Stomatitis Virus Vector System, Justine Baek Jan 2015

Expression Of Hiv-1 Gag And Env Genes Using The Vesicular Stomatitis Virus Vector System, Justine Baek

2015 Undergraduate Awards

Traditional vaccine methods have long been employed to control widespread infectious diseases, but so far, all commercially available vaccine strategies have been inadequate in efforts to develop an effective therapeutic HIV vaccine. However, recent advancements in immunological research have lead to the generation of novel vaccine strategies, one of which is the recombinant virus vaccine, a method of particular interest that has shown promise in the clearance of HIV infection within HIV-positive patients who have retained immunocompetence. This study examined the stability of the expression of HIV-1 genes, gag and env, through a recombinant virus vector, a recombinant vesicular stomatitis …