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Virginia Commonwealth University
Pharmacology and Toxicology Publications
PANCREATIC B-CELLS; INDUCED (I) OSCILLATIONS; BURSTING ELECTRICAL-ACTIVITY; INSULIN-SECRETING CELLS; SENSITIVE K+ CHANNELS; ENDOPLASMIC-RETICULUM; CYTOPLASMIC CA2+; SINGLE-MOUSE; ACTION-POTENTIALS; SYNCHRONOUS OSCILLATIONS
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Full-Text Articles in Medicine and Health Sciences
The Ca2+ Dynamics Of Isolated Mouse Β-Cells And Islets: Implications For Mathematical Models, Min Zhang, Paula Goforth, Richard Bertram, Arthur Sherman, Leslie S. Satin
The Ca2+ Dynamics Of Isolated Mouse Β-Cells And Islets: Implications For Mathematical Models, Min Zhang, Paula Goforth, Richard Bertram, Arthur Sherman, Leslie S. Satin
Pharmacology and Toxicology Publications
ABSTRACT
[Ca2+]i and electrical activity were compared in isolated β-cells and islets using standard techniques. In islets, raising glucose caused a decrease in [Ca2+]i followed by a plateau and then fast (2–3 min−1), slow (0.2–0.8 min−1), or a mixture of fast and slow [Ca2+]i oscillations. In β-cells, glucose transiently decreased and then increased [Ca2+]i, but no islet-like oscillations occurred. Simultaneous recordings of [Ca2+]i and electrical activity suggested that differences in [Ca2+]i signaling are due to …