Medicine and Health Sciences Commons^™

Tailoring The Immune Response By Targeting C-Type Lectin Receptors On Alveolar Macrophages Using “Pathogen-Like” Amphiphilic Polyanhydride Nanoparticles, Ana V. Chavez-Santicoy, Rajarshi Roychoudhury, Nicola L.B. Pohl, Michael J. Wannemeuhler, Balaji Narasimhan, Amanda E. Ramer-Tait

Amanda Ramer-Tait Publications

C-type lectin receptors (CLRs) offer unique advantages for tailoring immune responses. Engagement of CLRs regulates antigen presenting cell (APC) activation and promotes delivery of antigens to specific intracellular compartments inside APCs for efficient processing and presentation. In these studies, we have designed an approach for targeted antigen delivery by decorating the surface of polyanhydride nanoparticles with specific carbohydrates to provide pathogen-like properties. Two conserved carbohydrate structures often found on the surface of respiratory pathogens, galactose and di-mannose, were used to functionalize the surface of polyanhydride nanoparticles and target CLRs on alveolar macrophages (AMϕ), a principle respiratory tract APC. Co-culture of …