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The Role Of The L-Type Calcium Channel And Its Carboxyl-Terminus, Miranda Jean Byse
The Role Of The L-Type Calcium Channel And Its Carboxyl-Terminus, Miranda Jean Byse
University of Kentucky Doctoral Dissertations
In the heart, the primary role of the L-type calcium channel (LTCC) CaV1.2 is to conduct calcium into cardiomyocytes and initiate contraction. However, part of the CaV1.2 channel itself, the cleaved carboxyl-terminus (CCt) can also localize to the nucleus and regulate gene transcription. Therefore, the goal of this dissertation project was to determine the role and regulation of CCt in the embryonic and adult heart. The global hypothesis of my dissertation project is that CCt localizes to the nucleus in embryonic and adult cardiomyocytes via a calcium-mediated mechanism and regulates transcription. A model of pharmacological LTCC …