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Full-Text Articles in Medicine and Health Sciences
Clinical Course Of Covid-19 Disease In Immunosuppressed Renal Transplant Patients, Hamad Dhei̇r, Savaş Si̇pahi̇, Selçuk Yaylaci, Esma Seda Çeti̇n, Ahmed Bi̇lal Genç, Necatti̇n Firat, Mehmet Köroğlu, Gürkan Muratdaği, Yakup Tomak, Kezban Özmen Süner, Ömer Faruk Ateş, Oğuz Karabay
Clinical Course Of Covid-19 Disease In Immunosuppressed Renal Transplant Patients, Hamad Dhei̇r, Savaş Si̇pahi̇, Selçuk Yaylaci, Esma Seda Çeti̇n, Ahmed Bi̇lal Genç, Necatti̇n Firat, Mehmet Köroğlu, Gürkan Muratdaği, Yakup Tomak, Kezban Özmen Süner, Ömer Faruk Ateş, Oğuz Karabay
Turkish Journal of Medical Sciences
Background/aim: We aimed to identify clinical settings of renal transplant patients with COVID-19. Materials and methods: In this retrospective study, we included kidney transplant inpatients with laboratory confirmed COVID-19 who had been discharged or had died by October 1st, 2020. Characteristics of the patients, including basal and last outpatient biochemical parameters were recorded. Discontinuation or dosage reduction of immunosuppressives and other treatment information was documented. Results: Twenty patients were included in this study, of whom 18 were discharged and 2 died in hospital. The mean duration of hospitalization and follow-up were 9.7 ± 6.4 days and 4.5 ± 2.0 months, …
The Predictive And Diagnostic Accuracy Of Long Pentraxin-3 In Covid-19 Pneumonia, Ahmed Bi̇lal Genç, Selçuk Yaylaci, Hamad Dhei̇r, Ahmed Ci̇had Genç, Kubi̇lay İşsever, Deni̇z Çeki̇ç, Havva Kocayi̇ği̇t, Erdem Çokluk, Alper Karacan, Mehmet Ramazan Şekeroğlu, Hande Toptan, Ertuğrul Güçlü
The Predictive And Diagnostic Accuracy Of Long Pentraxin-3 In Covid-19 Pneumonia, Ahmed Bi̇lal Genç, Selçuk Yaylaci, Hamad Dhei̇r, Ahmed Ci̇had Genç, Kubi̇lay İşsever, Deni̇z Çeki̇ç, Havva Kocayi̇ği̇t, Erdem Çokluk, Alper Karacan, Mehmet Ramazan Şekeroğlu, Hande Toptan, Ertuğrul Güçlü
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study is to evaluate serum pentraxin-3 (PTX-3) levels in Sars-CoV-2 virus infection (COVID-19) patients and to investigate whether PTX-3 predicts the disease prognosis. Materials and methods: This study was conducted on 88 confirmed COVID-19 patients who were hospitalized due to symptomatic pneumonia between April 15 and August 15, 2020. The patients were divided into two groups as survived patients and non-survived patients. Both groups were compared according to demographic features, comorbid conditions and measurement of the PTX-3 and other laboratory parameters of the patients. Results: Of 88 patients with COVID-19, 59 (67%) were discharged with …
A Comparison Of Rates And Severity Of Chronic Kidney Disease In Deceased-Donor Andliving-Donor Liver Transplant Recipients: Times Matter, Yücel Yankol, Emily Bugeaud, Tiffany Zens, Michael Rizzari, Nesi̇mi̇ Meci̇t, Glen E. Leverson, David Foley, Joshua D. Mezrich, Turan Kanmaz, Oya Münevver Andaçoğlu, Anthony M. D'Alessandro, Koray Sadik Acarli, Münci̇ Kalayoğlu, Luis A. Fernandez
A Comparison Of Rates And Severity Of Chronic Kidney Disease In Deceased-Donor Andliving-Donor Liver Transplant Recipients: Times Matter, Yücel Yankol, Emily Bugeaud, Tiffany Zens, Michael Rizzari, Nesi̇mi̇ Meci̇t, Glen E. Leverson, David Foley, Joshua D. Mezrich, Turan Kanmaz, Oya Münevver Andaçoğlu, Anthony M. D'Alessandro, Koray Sadik Acarli, Münci̇ Kalayoğlu, Luis A. Fernandez
Turkish Journal of Medical Sciences
Background/aim: The progression of chronic kidney disease (CKD) in recipients of living-donor liver transplant (LDLT) compared to deceased-donor liver transplant (DDLT) has not been studied in the literature. We hypothesize that CKD stage progression in LDLT recipients is reduced compared to that of their DDLT counterparts. Materials and methods: A retrospective study was undertaken including 999 adult, single-organ, primary liver transplant recipients (218 LDLT and 781 DDLT) at 2 centers between January 2003 and December 2012, in which CKD progression and regression were evaluated within the first 3 years after transplantation. Results: Waiting time from evaluation to transplantation was significantly …
Can Thrombocytosis Or Thrombocytopenia Predict Complicated Clinical Course And30-Days Mortality In Patients With Pneumonia?, Razi̇ye Si̇nem Misirlioğlu, Ersi̇n Aksay, Emre Şanci, Kemal Can Tertemi̇z
Can Thrombocytosis Or Thrombocytopenia Predict Complicated Clinical Course And30-Days Mortality In Patients With Pneumonia?, Razi̇ye Si̇nem Misirlioğlu, Ersi̇n Aksay, Emre Şanci, Kemal Can Tertemi̇z
Turkish Journal of Medical Sciences
Background/aim: While several different scoring systems aim to determine the clinical outcomes for patients with pneumonia, there is limited emphasis on the platelet count. This study investigated the relationships between thrombocyte count and 30-day mortality and complicated clinical course of patients with pneumonia. Materials and methods: This prospective cross-sectional study enrolled patients over 18 years old with a diagnosis of pneumonia in the emergency department for six months. The primary outcome was to establish the relationship between platelet count, mortality, complicated clinical course, and initial vital parameters on admission. The secondary outcome was comparing the platelet count with mortality and …
Hydroxychloroquine Plus Azithromycin And Early Hospital Admission Are Beneficial Incovid-19 Patients: Turkish Experience With Real-Life Data, Eli̇f Tanriverdi̇, Mustafa Çörtük, Bi̇nnaz Zeynep Yildirim, Efsun Gonca Uğur Chousein, Demet Turan, Hali̇t Çinarka, Mehmet Aki̇f Özgül, Erdoğan Çeti̇nkaya
Hydroxychloroquine Plus Azithromycin And Early Hospital Admission Are Beneficial Incovid-19 Patients: Turkish Experience With Real-Life Data, Eli̇f Tanriverdi̇, Mustafa Çörtük, Bi̇nnaz Zeynep Yildirim, Efsun Gonca Uğur Chousein, Demet Turan, Hali̇t Çinarka, Mehmet Aki̇f Özgül, Erdoğan Çeti̇nkaya
Turkish Journal of Medical Sciences
Background/aim: New treatment regimens for COVID-19, which has threatened the world recently, continue to be investigated. Although some of the treatments are promising, it is thought to be early to state that there is definitive treatment. Experiences and treatment protocol studies from treatment centers are still important. The aim of this study is to evaluate factors affecting the treatment process of the first cases followed in our clinic. Materials and methods: The consecutive hospitalized patients with COVID-19 pneumonia were analyzed in this retrospective and cross-sectional study. Data were recorded from the electronic and written files of patients. Results: Eighty-three patients …
Hepatitis A Susceptibility Parallels High Covid-19 Mortality, Fai̇k Sariali̇oğlu, Fatma Burcu Belen, Kadi̇r Mutlu Hayran
Hepatitis A Susceptibility Parallels High Covid-19 Mortality, Fai̇k Sariali̇oğlu, Fatma Burcu Belen, Kadi̇r Mutlu Hayran
Turkish Journal of Medical Sciences
Background/aim:COVID-19 has become the biggest health problem of this century. It has been hypothesized that immunity against hepatitis A virus (HAV) may provide protection from COVID- 19. Materials and methods: As of 10June 2020, the infection had spread to 213 countries, with 7.3 million people infected and 413,733 dead. This data was combined with the World Health Organization susceptibility classification on the worldwide prevalence of HAV, and the relationship between HAV susceptibility and COVID-19 mortality were analyzed. Results: When the data from 213 countries were analyzed, it was found that there was a significant increasing trend in COVID-19 mortality rates …
Clinical Characteristics And Risk Factors For 28-Day Mortality In Critically Ill Patients With Covid-19: A Retrospective Cohort Study, Mehmet Nuri̇ Yakar, Begüm Ergan, Bi̇şar Ergün, Murat Küçük, Ali̇ Cantürk, Mahmut Cem Ergon, Naci̇ye Si̇nem Gezer, Erdem Yaka, Bi̇lgi̇n Cömert, Ali̇ Necati̇ Gökmen
Clinical Characteristics And Risk Factors For 28-Day Mortality In Critically Ill Patients With Covid-19: A Retrospective Cohort Study, Mehmet Nuri̇ Yakar, Begüm Ergan, Bi̇şar Ergün, Murat Küçük, Ali̇ Cantürk, Mahmut Cem Ergon, Naci̇ye Si̇nem Gezer, Erdem Yaka, Bi̇lgi̇n Cömert, Ali̇ Necati̇ Gökmen
Turkish Journal of Medical Sciences
Background: To date, the coronavirus disease 2019 (COVID-19) caused more than 2.6 million deaths all around the world. Risk factors for mortality remain unclear. The primary aim was to determine the independent risk factors for 28-day mortality. Materials and Methods: In this retrospective cohort study, critically ill patients (≥ 18 years) who were admitted to the intensive care unit due to COVID-19 were included. Patient characteristics, laboratory data, radiologic findings, treatments, and complications were analyzed in the study. Results: A total of 249 patients (median age 71, 69.1% male) were included in the study. 28-day mortality was 67.9% (n = …
Incidence, Risk Factors, And Adverse Outcomes Of Acute Kidney Injury In Very Prematureneonates: A Single Center Experience, Nuran Üstün
Turkish Journal of Medical Sciences
Background/aim: Acute kidney injury (AKI) is a serious morbidity in premature neonates. The aim of this study was to determine the incidence of AKI and to evaluate its impact on morbidity and mortality in very premature infants. Materials and methods: This retrospective cohort study was conducted in the neonatal intensive care unit (NICU). A total of 410 preterm infants who were born before 32 gestational weeks were screened and 318 were included in this analysis. AKI was defined according to the modified neonatal Kidney Disease: Improving Global Outcomes criteria. Results: The incidence of AKI was 32.1% (102/318). Regression analyses revealed …
Factors Affecting Mortality In Geriatric Patients Hospitalized With Covid-19, Rabi̇a Bağ Soytaş, Damla Ünal, Pinar Arman, Veysel Suzan, Tuğçe Emi̇roğlu Gedi̇k, Günay Can, Bora Korkmazer, Ridvan Karaali̇, Şermi̇n Börekçi̇, Mert Ahmet Kuşkucu, Hakan Yavuzer, Ülev Deni̇z Erdi̇nçler, Alper Döventaş
Factors Affecting Mortality In Geriatric Patients Hospitalized With Covid-19, Rabi̇a Bağ Soytaş, Damla Ünal, Pinar Arman, Veysel Suzan, Tuğçe Emi̇roğlu Gedi̇k, Günay Can, Bora Korkmazer, Ridvan Karaali̇, Şermi̇n Börekçi̇, Mert Ahmet Kuşkucu, Hakan Yavuzer, Ülev Deni̇z Erdi̇nçler, Alper Döventaş
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate the factors affecting the mortality of patients aged 65 years or older who were hospitalized with the diagnosis of new coronavirus pneumonia (COVID-19). Materials and methods: This is a retrospective study of patients 65 years old or older with COVID-19 who were hospitalized in İstanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty Hospital, between March 11 and May 28, 2020. Demographic, clinical, treatment, and laboratory data were extracted from electronic medical records. We used univariate and multivariate logistic regression methods to explore the risk factors for in-hospital death. Results: A total of 218 patients (112 men, 106 women) …
Evaluation Of Initial Chest Computed Tomography (Ct) Findings Of Covid-19pneumonia In 117 Deceased Patients: A Retrospective Study, Yasemi̇n Gündüz, Oğuz Karabay, Ali̇ Fuat Erdem, Erbi̇l Arik, Mehmet Hali̇l Öztürk
Evaluation Of Initial Chest Computed Tomography (Ct) Findings Of Covid-19pneumonia In 117 Deceased Patients: A Retrospective Study, Yasemi̇n Gündüz, Oğuz Karabay, Ali̇ Fuat Erdem, Erbi̇l Arik, Mehmet Hali̇l Öztürk
Turkish Journal of Medical Sciences
Background/aim: There is no study in the literature in which only chest computed tomography (CT) findings of deceased cases obtained at admission were examined, and the relationship between these findings and mortality was evaluated. Materials and methods: In this retrospective study, a total of 117 deceased patients with COVID-19 infection confirmed by positive polymerase chain reaction and undergone chest CT were enrolled. We evaluated initial chest CT findings and their relationship, location, prevalence, and the frequency with mortality. Results: The mean age of patients was 73 ±18 years; 71 of all patients were male and 46 were female. The predominant …
Impact Of Hospital-Acquired Acute Kidney Injury On Covid-19 Outcomes In Patients Withand Without Chronic Kidney Disease: A Multicenter Retrospective Cohort Study, Savaş Öztürk, Kenan Turgutalp, Mustafa Arici, Hakki Çeti̇nkaya, Mehmet Riza Altiparmak, Zeki̇ Aydin, Zeki̇ Soypaçaci, Feyza Bora, Ekrem Kara, Egemen Cebeci̇, Tuba Eli̇f Özler, Mürşi̇de Esra Dölarslan, Savaş Si̇pahi̇, Yavuz Ayar, İdri̇s Şahi̇n
Impact Of Hospital-Acquired Acute Kidney Injury On Covid-19 Outcomes In Patients Withand Without Chronic Kidney Disease: A Multicenter Retrospective Cohort Study, Savaş Öztürk, Kenan Turgutalp, Mustafa Arici, Hakki Çeti̇nkaya, Mehmet Riza Altiparmak, Zeki̇ Aydin, Zeki̇ Soypaçaci, Feyza Bora, Ekrem Kara, Egemen Cebeci̇, Tuba Eli̇f Özler, Mürşi̇de Esra Dölarslan, Savaş Si̇pahi̇, Yavuz Ayar, İdri̇s Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: Hospital-acquired acute kidney injury (HA-AKI) may commonly develop in Covid-19 patients and is expected to have higher mortality. There is little comparative data investigating the effect of HA-AKI on mortality of chronic kidney disease (CKD) patients and a control group of general population suffering from Covid-19. Materials and methods: HA-AKI development was assessed in a group of stage 3-5 CKD patients and control group without CKD among adult patients hospitalized for Covid-19. The role of AKI development on the outcome (in-hospital mortality and admission to the intensive care unit [ICU]) of patients with and without CKD was compared. Results: …
The Effect Of Comorbidity On Mortality In Elderly Patients Undergoing Emergencyabdominal Surgery: A Systematic Review And Metaanalysis, Fadi̇me Çinar, Göknur Parlak, Fatma Eti̇ Aslan
The Effect Of Comorbidity On Mortality In Elderly Patients Undergoing Emergencyabdominal Surgery: A Systematic Review And Metaanalysis, Fadi̇me Çinar, Göknur Parlak, Fatma Eti̇ Aslan
Turkish Journal of Medical Sciences
Background/aim: With the increase in the elderly population, the elderly proportion needing emergency surgery is also increasing. Despite medical advances in surgery and anesthesia, negative postoperative outcomes and high mortality rates are still present in elderly patients undergoing emergency surgery. Comorbidities are described as the main determining factors in poor outcomes. In this metaanalysis, it was aimed to investigate the effect of comorbidity on mortality in elderly patients undergoing emergency abdominal surgery. Materials and methods: The studies published between 2010-2019 were scanned from databases of Google Scholar, Cinahl, Pub Med, Medline and Web of Science. Quality criteria proposed by Polit …
The Comparison Of Favipiravir And Lopinavir/Ritonavir Combination In Covid-19treatment, Hali̇t Çinarka, Gülşah Günlüoğlu, Mustafa Çörtük, Si̇bel Yurt, Murat Kiyik, Ayşe Fi̇li̇z Koşar, Eli̇f Tanriverdi̇, Meli̇h Akay Arslan, Kürşad Nuri̇ Baydi̇li̇, Aysu Si̇nem Koç, Sedat Altin, Erdoğan Çeti̇nkaya
The Comparison Of Favipiravir And Lopinavir/Ritonavir Combination In Covid-19treatment, Hali̇t Çinarka, Gülşah Günlüoğlu, Mustafa Çörtük, Si̇bel Yurt, Murat Kiyik, Ayşe Fi̇li̇z Koşar, Eli̇f Tanriverdi̇, Meli̇h Akay Arslan, Kürşad Nuri̇ Baydi̇li̇, Aysu Si̇nem Koç, Sedat Altin, Erdoğan Çeti̇nkaya
Turkish Journal of Medical Sciences
Background/aim: SARS-CoV-2, a ribonucleic acid coronavirus, rapidly spread worldwide within a short timeframe. Although different antiviral, antiinflammatory, and immunomodulatory drugs are used, current evidence is insufficient as to which drug is more efficient. Our study compared favipiravir and lopinavir/ritonavir (LPV/RTV) therapies in inpatient care for coronavirus disease 2019 (COVID-19) pneumonia. Materials and methods: Demographic data, test results, treatments, and latest status of patients receiving inpatient COVID-19 pneumonia therapy were recorded. The initial favipiravir and LPV/RTV receiving groups were compared regarding the need for intensive care units (ICU) and mortality. Logistic regression analysis was performed by including variables showing significant differences …
Long-Term Proton Pump Inhibitor Use Is A Risk Factor For Mortality In Patientshospitalized For Covid-19, Ahmet Yozgat, Benan Kasapoğlu, Güray Can, Alpaslan Tanoğlu, Yusuf Serdar Saki̇n, Kadi̇r Serkan Yalçin, Müjgan Gürler, Mustafa Kaplan, Mehmet Göktürk Kaban, Mehmet Kirsoy, Umut Kara, Murat Keki̇lli̇
Long-Term Proton Pump Inhibitor Use Is A Risk Factor For Mortality In Patientshospitalized For Covid-19, Ahmet Yozgat, Benan Kasapoğlu, Güray Can, Alpaslan Tanoğlu, Yusuf Serdar Saki̇n, Kadi̇r Serkan Yalçin, Müjgan Gürler, Mustafa Kaplan, Mehmet Göktürk Kaban, Mehmet Kirsoy, Umut Kara, Murat Keki̇lli̇
Turkish Journal of Medical Sciences
Background and aim: The aim of this study is to evaluate whether the long-term (≥4 weeks) use of proton pump inhibitors (PPIs) is a risk factor for intubation requirement and mortality in patients hospitalized for COVID-19. Materials and methods: In this multicentric retrospective study, a total of 382 adult patients (≥18 years of age) with confirmed COVID-19 who were hospitalized for treatment were enrolled. The patients were divided into two groups according to the periods during which they used PPIs: the first group included patients who were not on PPI treatment, and the second group included those who have used …
Prognostic Factors For 30-Days Mortality In Eighty Years Aged And Older Critically Illpatients: A Single Center Retrospective Cohort Study, Umut Sabri̇ Kasapoğlu, Osman Kaçmaz, Abdullah Gök, Meri̇h Yildiz Eglen, Hasan Şayan, Fati̇h Çolak
Prognostic Factors For 30-Days Mortality In Eighty Years Aged And Older Critically Illpatients: A Single Center Retrospective Cohort Study, Umut Sabri̇ Kasapoğlu, Osman Kaçmaz, Abdullah Gök, Meri̇h Yildiz Eglen, Hasan Şayan, Fati̇h Çolak
Turkish Journal of Medical Sciences
Background/aim: Nowadays, with the rise in average life expectancy, the rate of hospitalization of the older population in intensive care unit (ICU) is gradually increasing. Unfortunately, there are no ideal combination of prognostic factors predicting the mortality in older patients admitted to the ICU. In the present study, we aim to determine the prognostic factors and their impacts on short-time mortality in older critically ill patients. Materials and methods: This retrospective cohort study was performed between January 2019 and February 2020. We included 133 patients aged ≥80 years and hospitalized ≥24 h in the ICU. Results: A total of 133 …