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Full-Text Articles in Medicine and Health Sciences
Measurement Of Cerebral And Cerebellar Volumes In Children With Fragile X Syndrome, Ni̇met Kabakuş, Mustafa Aydin, Ahmet Kavakli, Hanefi̇ Yildirim, Haluk Akin
Measurement Of Cerebral And Cerebellar Volumes In Children With Fragile X Syndrome, Ni̇met Kabakuş, Mustafa Aydin, Ahmet Kavakli, Hanefi̇ Yildirim, Haluk Akin
Turkish Journal of Medical Sciences
Background and Aim: Fragile X syndrome (FXS) is a genetic disease associated with mental retardation, speech and memory deficits, developmental/learning disabilities, and, frequently, also with neuropsychological findings. It is known that all these abnormal brain functions could be associated with morphological anomalies of various brain regions. We investigated possible brain volume variations in children with FXS who had significant neurobehavioral symptoms and cognitive deficits. Patients and Methods: This study was performed with 8 male FXS patients who were diagnosed cytogenetically. The Leiter International Performance Scales-Revised, the Stanford-Binet Intelligence Scale, the Vineland Social Maturity Scale, and DSM IV criteria were used …
Communicating Hydrocephalus In Systemic Lupus Erythematosus, Ramazan Albayrak, Sai̇t Albayram, Hakan Selçuk, Sebahatti̇n Sai̇p, Hali̇t Yilmaz, Ci̇van Işlak
Communicating Hydrocephalus In Systemic Lupus Erythematosus, Ramazan Albayrak, Sai̇t Albayram, Hakan Selçuk, Sebahatti̇n Sai̇p, Hali̇t Yilmaz, Ci̇van Işlak
Turkish Journal of Medical Sciences
Central nervous system (CNS) involvement has been recognized as the second leading cause of death in patients with systemic lupus erythematosus (SLE), although hydrocephalus is seen very rarely. We report a case of communicating hydrocephalus in a 24-year-old woman having previously diagnosed SLE without antiphospholipid antibody syndrome or cerebral venous angiographic abnormality. We propose direct damage-thrombosis of small sized venous structures or immune complex deposition within arachnoid villi, which impair cerebrospinal fluid flow, as a possible, yet unproven, pathophysiologic mechanism for hydrocephalus in SLE.