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Mao Inhibitors In Aging: Can They Serve As Protective Agents In Cardiac Tissue Against Oxidative Stress?, Ferhan Külahçioğlu Gi̇rgi̇n, Mert Özgönül, Güli̇nnaz Alper, Gülri̇z Menteş, Bi̇ltan Ersöz, Eser Yildirim Sözmen

Turkish Journal of Medical Sciences

Biological damage mediated by reactive oxygen species has been increasingly recognized in aging phenomena in recent decades. The increase in catecholamine metabolism is yet another physiological change in aging, predisposing the organism to supranormal hydrogen peroxide produc-tion as a by-product. This study was undertaken to investigate the alterations in oxidant- antioxidant status in rat cardiac tissue during aging. The effects of acute administration of monoamine oxidase (MAO) inhibitors on this status were also investigated to find possible preventive strategies in conjugate aging. MAO activities, malondialdehyde MDA and diene conjugate levels as well as superoxide dismutase and catalase activities were determined …