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Hepatoprotective Effects Of Orthosiphon Stamineus Extract On Thioacetamide-Induced Liver Cirrhosis In Rats, Mohammed A. Alshawsh, Mahmood A. Abdulla, Ismail Salmah, Zahra A. Amin
Hepatoprotective Effects Of Orthosiphon Stamineus Extract On Thioacetamide-Induced Liver Cirrhosis In Rats, Mohammed A. Alshawsh, Mahmood A. Abdulla, Ismail Salmah, Zahra A. Amin
Mohammed A Alshawsh
Orthosiphon stamineus as medicinal plant is commonly used in Malaysia for treatment of hepatitis and jaundice; in this study, the ethanol extracts were applied to evaluate the hepatoprotective effects in a thioacetamide-induced hepatotoxic model in Sprague Dawley rats. Five groups of adult rats were arranged as follows:Group 1 (normal control group), Group 2 Thioacetamide (TAA) as positive control (hepatotoxic group), Group 3 Silymarin as a well-known standard drug (hepatoprotective group), and Groups 4 and 5 as high and low dose (treatment groups). After 60-day treatment, all rats were sacrificed. The hepatotoxic group showed a coarse granulation on the liver surface …