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Medical Sciences

Selected Works

Helen O'Neill

Selected Works

2012

Articles 1 - 5 of 5

Full-Text Articles in Medicine and Health Sciences

An In Vitro Microenvironment That Supports The Development Of A Novel Dendritic Cell From Bone Marrow And Spleen Hsc, Pravin Periasamy, Helen O'Neill Dec 2011

An In Vitro Microenvironment That Supports The Development Of A Novel Dendritic Cell From Bone Marrow And Spleen Hsc, Pravin Periasamy, Helen O'Neill

Helen O'Neill

No abstract provided.

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Tedchnical Advance: In Vitro Production Of Distinct Dendritic-Like Antigen Presenting Cells From Self-Renewing Hematopoietic Stem Cells, Rebecca Hinton, Helen O'Neill Dec 2011

Tedchnical Advance: In Vitro Production Of Distinct Dendritic-Like Antigen Presenting Cells From Self-Renewing Hematopoietic Stem Cells, Rebecca Hinton, Helen O'Neill

Helen O'Neill

No abstract provided.

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Molecular Definition Of A Hematopoietic Niche In Spleen, Pravan Periasamy, Helen O'Neill Dec 2011

Molecular Definition Of A Hematopoietic Niche In Spleen, Pravan Periasamy, Helen O'Neill

Helen O'Neill

No abstract provided.

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In Vitro Differentiation Of Novel Antigen Presenting Cells, Sawang Petvises, Pravin Periasamy, Helen O'Neill Dec 2011

In Vitro Differentiation Of Novel Antigen Presenting Cells, Sawang Petvises, Pravin Periasamy, Helen O'Neill

Helen O'Neill

No abstract provided.

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Myelopoiesis In Spleen Producing Distinct Dendritic-Like Cells, Jonathan Tan, Helen O'Neill Dec 2011

Myelopoiesis In Spleen Producing Distinct Dendritic-Like Cells, Jonathan Tan, Helen O'Neill

Helen O'Neill

Dendritic cells (DC) represent a heterogeneous class of antigen presenting cells (APC). Previously we reported a distinct myeloid dendritic-like cell present in spleen, as an in vivo counterpart to cells produced in murine spleen long-term cultures (LTC-DC). These cells, named 'L-DC', were found to be functionally and phenotypically distinct from conventional (c)DC, plasmacytoid (p)DC and monocytes. These results suggested that spleen may represent a niche for development of L-DC from endogenous progenitors. Adult murine spleen has now been investigated for the presence of L-DC progenitors. Lineage-negative (Lin)-ckitlo and Lin-ckithi progenitor subsets were identified as candidate populations, and tested for ability …

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