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Full-Text Articles in Medicine and Health Sciences
Effect Of Metformin Exposure On Growth And Photosynthetic Performance In The Unicellular Freshwater Chlorophyte, Chlorella Vulgaris, Brittany M. Cummings, Joseph A. Needoba, Tawnya D. Peterson
Effect Of Metformin Exposure On Growth And Photosynthetic Performance In The Unicellular Freshwater Chlorophyte, Chlorella Vulgaris, Brittany M. Cummings, Joseph A. Needoba, Tawnya D. Peterson
OHSU-PSU School of Public Health Faculty Publications and Presentations
Many pharmaceuticals have negative effects on biota when released into the environment. For example, recent work has shown that the commonly prescribed antidiabetic drug, metformin (N,N-dimethylbiguanide), has endocrine disrupting effects on fish. However, effects of metformin on aquatic primary producers are poorly known. We exposed cultured isolates of a freshwater chlorophyte, Chlorella vulgaris, to a range of metformin concentrations (0– 767.9 mg L-1) to test the hypothesis that exposure negatively affects photosynthesis and growth. A cessation of growth, increase in non-photochemical quenching (NPQ, NPQmax), and reduced electron transport rate (ETR) were observed 24 h after exposure to a metformin concentration …
United States State-Level Variation In The Use Of Neuraxial Analgesia During Labor For Pregnant Women, Alexander Butwick, Jason Bentley, Cynthia Wong, Jonathan Snowden, Eric Sun, Nan Guo
United States State-Level Variation In The Use Of Neuraxial Analgesia During Labor For Pregnant Women, Alexander Butwick, Jason Bentley, Cynthia Wong, Jonathan Snowden, Eric Sun, Nan Guo
OHSU-PSU School of Public Health Faculty Publications and Presentations
Importance Neuraxial labor analgesia is recognized as the most effective method of providing pain relief during labor. Little is known about variation in the rates of neuraxial analgesia across US states. Identifying the presence and extent of variation may provide insights into practice variation and may indicate where access to neuraxial analgesia is inadequate. Objective To test the hypothesis that variation exists in neuraxial labor analgesia use among US states. Design, Setting, and Participants Retrospective, population …