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Full-Text Articles in Medicine and Health Sciences

Examining The Effects Of Exercise-Induced, Physical Stress Overtraining On Stress Biomarkers In Adolescent, C57bl/6 Mice, Curtis Scotty Davis Jan 2022

Examining The Effects Of Exercise-Induced, Physical Stress Overtraining On Stress Biomarkers In Adolescent, C57bl/6 Mice, Curtis Scotty Davis

Theses, Dissertations and Capstones

Exercise has long been established as a therapeutic modality to improve health and related physical fitness, sports performance, and injury/risk reduction in both adults and adolescents (Haff & Triplett, 2015; Kaminsky, 2010). Nonetheless, there is a lack of research investigating the negative effects of exercise overstress (i.e., overtraining syndrome) in these populations, particularly adolescents (Brenner & American Academy of Pediatrics Council on Sports Medicine and Fitness, 2007; Matos & Winsley, 2007). The objective of this study was to examine hormone biochemical markers, anthropometric markers, and behavioral traits, which are associated with overtraining syndrome, in adolescent C57BL/6 mice. A total of …


Current And Novel Neuroregenerative Therapies, Arrin Brooks Jan 2022

Current And Novel Neuroregenerative Therapies, Arrin Brooks

Theses, Dissertations and Capstones

Underlying the physical and cognitive deficits consequent of many neuropathologies is one common factor, the loss of neurons. While neurodegenerative diseases, stroke, and traumatic brain injury arise from a variety of etiologies, they all ultimately result in injury and/or death of neuronal cells and concomitant functional deficits. In the present work we primarily focus on current and potential treatments for localized lesions, particularly those in the striatum of Parkinson’s disease (PD) or the cortex as in stroke. First, we discuss a new surgical technique for deep brain stimulator (DBS) placement, as DBS is a mainstay treatment for movement disorders including …


A Systems Approach To Dissecting The Role Of The Mucosal Microbiome In Disease, Lexie Christine Blalock Jan 2022

A Systems Approach To Dissecting The Role Of The Mucosal Microbiome In Disease, Lexie Christine Blalock

Theses, Dissertations and Capstones

The microbial community harbored by the mammalian gastrointestinal tract, collectively called the gut microbiota, plays a critical role in host health, metabolism, and immunity. Quantifiable changes in the gut microbiota have been implicated in a myriad of pathologies, including autoimmune, metabolic, and neurodegenerative diseases. Because of the gut microbiota’s plasticity, manipulating this community for therapeutic benefit presents as a novel strategy to combat modern diseases. Yet, only a fraction of the total microbial diversity that exists within the gut has been successfully cultured in a laboratory, leaving the clinical implications and functional attributes of many gut microbes undetermined. To address …


A Retrospective Analysis Of Ebola Virus Disease In Liberia, Matthew Jeremiah Matson Jan 2022

A Retrospective Analysis Of Ebola Virus Disease In Liberia, Matthew Jeremiah Matson

Theses, Dissertations and Capstones

The outbreak of Ebola virus disease (EVD) centered in the West African countries of Guinea, Liberia, and Sierra Leone from 2013-2016 was the longest and largest such outbreak on record. At least 30,000 cases were reported, and the outbreak lasted nearly two-and-a-half years. Despite the progress made during and since that time, many questions remain unanswered. The studies here utilize a large set of nearly 750 whole blood samples from patients that were triaged and treated at the ELWA-3 Ebola treatment unit in Monrovia, Liberia in 2014 and 2015. Viral load, as approximated by qRT-PCR diagnostic assays in the field, …