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The Role Of Fibrinogen D Domain Intermolecular Association Sites In The Polymerization Of Fibrin And Fibrinogen Tokyo Ii (Γ275 Arg→Cys), Michael W. Mosesson, Kevin R. Siebenlist, James P. Diorio, M. Matsuda, James F. Hainfeld, J. S. Wall

Biomedical Sciences Faculty Research and Publications

Intermolecular end-to-middle domain pairing between a thrombin-exposed 'A' polymerization site in the central 'E' domain of fibrin, and a constitutive complementary 'a' site in each outer 'D' domain ('D:E'), is necessary but not alone sufficient for normal fibrin assembly, as judged from previous studies of a congenital dysfibrinogen, Tokyo II (gamma 275 arg-->cys), which showed defective fibrin clot assembly and a normal D:E interaction (Matsuda, M., M. Baba, K. Morimoto, and C. Nakamikawa, 1983. J. Clin. Invest. 72:1034-1041). In addition to the 'a' polymerization site, two other constitutive intermolecular association sites on fibrinogen D domains have been defined: between …