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Full-Text Articles in Medicine and Health Sciences
The Esophageal Propulsive Force: Esophageal Response To Acute Obstruction, Daniel H. Winship, F. Frank Zboralske
The Esophageal Propulsive Force: Esophageal Response To Acute Obstruction, Daniel H. Winship, F. Frank Zboralske
Biomedical Sciences Faculty Research and Publications
The response of the normal human esophagus to an obstructing intraluminal bolus was investigated and compared to the response evoked by transient intraluminal distention. A balloon, immobilized within the esophagus by external attachment to a force transducer, was inflated with from 3 to 25 ml of air for from 3 to 210 sec. Pressure phenomena occurring in the esophagus were simultaneously recorded from the body of the esophagus above and below the balloon.
Transient distention (5 sec or less) with small volumes (5 ml or less) often evoked a secondary peristaltic wave in the esophagus distal to the balloon, but …
Studies Of The Mechanism By Which Chronic Metabolic Acidosis Augments Urinary Calcium Excretion In Man, Jacob Lemann Jr., John R. Litzow, Edward J. Lennon
Studies Of The Mechanism By Which Chronic Metabolic Acidosis Augments Urinary Calcium Excretion In Man, Jacob Lemann Jr., John R. Litzow, Edward J. Lennon
Biomedical Sciences Faculty Research and Publications
We carried out clearance studies in nine healthy adults and four patients with hypoparathyroidism before and after inducing stable metabolic acidosis with either NH4Cl or acetazolamide. Clearances were repeated in seven normal subjects and three of the patients 3 days after stopping these agents.
During acidosis in the normal subjects, serum ultrafilterable calcium concentration rose significantly, but inulin clearance fell to a greater extent, so that the calculated filtered load of calcium fell significantly. Despite this, urinary calcium excretion rose. Urinary calcium excretion remained elevated in the recovery studies when the serum ultrafilterable calcium concentration and filtered load …
The Effect Of Treatment Of Acidosis On Calcium Balance In Patients With Chronic Azotemic Renal Disease, John R. Litzow, Jacob Lemann Jr., Edward J. Lennon
The Effect Of Treatment Of Acidosis On Calcium Balance In Patients With Chronic Azotemic Renal Disease, John R. Litzow, Jacob Lemann Jr., Edward J. Lennon
Biomedical Sciences Faculty Research and Publications
Small but statistically significant negative calcium balances were found in each of eight studies in seven patients with chronic azotemic renal disease when stable metabolic acidosis was present. Only small quantities of calcium were excreted in the urine, but fecal calcium excretion equaled or exceeded dietary intake. Complete and continuous correction of acidosis by NaHCO3 therapy reduced both urinary and fecal calcium excretion and produced a daily calcium balance indistinguishable from zero.
Apparent acid retention was found throughout the studies during acidosis, despite no further reduction of the serum bicarbonate concentration. The negative calcium balances that accompanied acid retention …