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Catecholamines In The Bed Nucleus Of The Stria Terminalis Reciprocally Respond To Reward And Aversion, Robert A. Wheeler
Catecholamines In The Bed Nucleus Of The Stria Terminalis Reciprocally Respond To Reward And Aversion, Robert A. Wheeler
Biomedical Sciences Faculty Research and Publications
Background
Traditionally, norepinephrine has been associated with stress responses, whereas dopamine has been associated with reward. Both of these catecholamines are found within the bed nucleus of the stria terminalis (BNST), a brain relay nucleus in the extended amygdala between cortical/limbic centers, and the hypothalamic-pituitary-adrenal axis. Despite this colocalization, little is known about subsecond catecholamine signaling in subregions of the BNST in response to salient stimuli.
Methods
Changes in extracellular catecholamine concentration in subregions of the BNST in response to salient stimuli were measured within the rat BNST with fast-scan cyclic voltammetry at carbon-fiber microelectrodes.
Results
A discrete subregional distribution …