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Full-Text Articles in Medicine and Health Sciences
Cocaine Enhances Hiv-1 Infectivity In Monocyte Derived Dendritic Cells By Suppressing Microrna-155, Jessica Napuri, Sudheesh Pilakka-Kanthikeel, Andrea Raymond, Marisela Agudelo, Adriana Yndart-Arias, Madhavan Nair, Shailendra K. Saxena
Cocaine Enhances Hiv-1 Infectivity In Monocyte Derived Dendritic Cells By Suppressing Microrna-155, Jessica Napuri, Sudheesh Pilakka-Kanthikeel, Andrea Raymond, Marisela Agudelo, Adriana Yndart-Arias, Madhavan Nair, Shailendra K. Saxena
HWCOM Faculty Publications
Cocaine and other drugs of abuse increase HIV-induced immunopathogenesis; and neurobiological mechanisms of cocaine addiction implicate a key role for microRNAs (miRNAs), single-stranded non-coding RNAs that regulate gene expression and defend against viruses. In fact, HIV defends against miRNAs by actively suppressing the expression of polycistronic miRNA cluster miRNA-17/92, which encodes miRNAs including miR-20a. IFN-g production by natural killer cells is regulated by miR-155 and this miRNA is also critical to dendritic cell (DC) maturation. However, the impact of cocaine on miR-155 expression and subsequent HIV replication is unknown. We examined the impact of cocaine on two miRNAs, miR-20a and …
Targeted Brain Derived Neurotropic Factors (Bdnf) Delivery Across The Blood-Brain Barrier For Neuro-Protection Using Magnetic Nano Carriers: An In-Vitro Study, Sudheesh Pilakka-Kanthikeel, Venkata Subba Rao Atluri, Vidya Sagar, Shailendra K. Saxena, Madhavan Nair
Targeted Brain Derived Neurotropic Factors (Bdnf) Delivery Across The Blood-Brain Barrier For Neuro-Protection Using Magnetic Nano Carriers: An In-Vitro Study, Sudheesh Pilakka-Kanthikeel, Venkata Subba Rao Atluri, Vidya Sagar, Shailendra K. Saxena, Madhavan Nair
HWCOM Faculty Publications
Parenteral use of drugs; such as opiates exert immunomodulatory effects and serve as a cofactor in the progression of HIV-1 infection, thereby potentiating HIV related neurotoxicity ultimately leading to progression of NeuroAIDS. Morphine exposure is known to induce apoptosis, down regulate cAMP response element-binding (CREB) expression and decrease in dendritic branching and spine density in cultured cells. Use of neuroprotective agent; brain derived neurotropic factor (BDNF), which protects neurons against these effects, could be of therapeutic benefit in the treatment of opiate addiction. Previous studies have shown that BDNF was not transported through the blood brain barrier (BBB) in-vivo.; …
Human Synaptic Plasticity Gene Expression Profile And Dendritic Spine Density Changes In Hiv-Infected Human Cns Cells: Role In Hiv-Associated Neurocognitive Disorders (Hand), Venakata Subba Rao Alturi, Sudheesh P. Kanthikeel, Pichili V.B. Reddy, Adriana Yndart, Madhavan P.N. Nair
Human Synaptic Plasticity Gene Expression Profile And Dendritic Spine Density Changes In Hiv-Infected Human Cns Cells: Role In Hiv-Associated Neurocognitive Disorders (Hand), Venakata Subba Rao Alturi, Sudheesh P. Kanthikeel, Pichili V.B. Reddy, Adriana Yndart, Madhavan P.N. Nair
HWCOM Faculty Publications
HIV-associated neurocognitive disorders (HAND) is characterized by development of cognitive, behavioral and motor abnormalities, and occur in approximately 50% of HIV infected individuals. Our current understanding of HAND emanates mainly from HIV-1 subtype B (clade B), which is prevalent in USA and Western countries. However very little information is available on neuropathogenesis of HIV-1 subtype C (clade C) that exists in Sub-Saharan Africa and Asia. Therefore, studies to identify specific neuropathogenic mechanisms associated with HAND are worth pursuing to dissect the mechanisms underlying this modulation and to prevent HAND particularly in clade B infection. In this study, we have investigated …
Investigation Of The Frequency Of The Mutant Ccr5-Δ32 Allele Related To Hiv Resistance In Turkey, Gamze Karakaya, Fatma Azi̇ze Budak Yildiran, Şükran Çakir Arica
Investigation Of The Frequency Of The Mutant Ccr5-Δ32 Allele Related To Hiv Resistance In Turkey, Gamze Karakaya, Fatma Azi̇ze Budak Yildiran, Şükran Çakir Arica
Turkish Journal of Medical Sciences
To determine the frequency with which the CCR5-\Delta32 mutant allele caused resistance to HIV, which is main agent of AIDS in all geographic regions of Turkey. Materials and methods: Randomly selected human blood samples from 400 healthy individuals were collected. The polymerase chain reaction method was used to determine the CCR5-\Delta32 polymorphism and samples were screened using 2 primers. Results: The frequency of wild alleles was found to be 0.9738 and the frequency of mutant alleles was found to be 0.0262. The highest frequency of the CCR5-\Delta32 allele was found to be 0.0726 in the Central Anatolia region. The lowest …