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Full-Text Articles in Medicine and Health Sciences
Hybrid Adult Neuron Culture Systems For Use In Pharmacological Testing, Darin Keay Edwards
Hybrid Adult Neuron Culture Systems For Use In Pharmacological Testing, Darin Keay Edwards
Electronic Theses and Dissertations
Neuronal culture systems have many applications, such as basic research into neuronal structure, function, and connectivity as well as research into diseases, conditions, and injuries affecting the brain and its components. In vitro dissociated neuronal systems have typically been derived from embryonic brain tissue, most commonly from the hippocampus of E18 rats. This practice has been motivated by difficulties in supporting regeneration, functional recovery and long-term survival of adult neurons in vitro. The overall focus of this dissertation research was to develop a dissociated neuronal culture system from human and animal adult brain tissue, one more functionally and developmentally correlative …
Potential Role Of Some Nutraceuticals In The Regression Of Alzheimer’S Disease In An Experimental Animal Model, Hanaa Hamdy Ahmed, Wafaa Ghoneim Shousha, Rehab Mahmoud Hussien, Abdel Razik Hussein Farrag
Potential Role Of Some Nutraceuticals In The Regression Of Alzheimer’S Disease In An Experimental Animal Model, Hanaa Hamdy Ahmed, Wafaa Ghoneim Shousha, Rehab Mahmoud Hussien, Abdel Razik Hussein Farrag
Turkish Journal of Medical Sciences
The goal of this study was to evaluate the potential role of some nutraceuticals, coenzyme Q_{10}, vitamin B complex, and lecithin against aluminum-induced neurodegeneration characteristic of Alzheimer's disease. Materials and methods: Ninety-six male and female Sprague Dawley rats were divided into 2 main groups, namely female and male. Each group was divided into 6 subgroups. Group 1 served as control group. Group 2 was administered AlCl_3 for 4 months. Groups 3, 4, 5, and 6 were administered with AlCl_3 for 4 months then treated with Coenzyme Q_{10}, vitamin B complex, lecithin, or all in combination for 3 months, respectively. Brain …