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Full-Text Articles in Medicine and Health Sciences
A Requirement For Bone Morphogenetic Protein-7 During Development Of The Mammalian Kidney And Eye., Andrew T. Dudley, K. M. Lyons, E. J. Robertson
A Requirement For Bone Morphogenetic Protein-7 During Development Of The Mammalian Kidney And Eye., Andrew T. Dudley, K. M. Lyons, E. J. Robertson
Journal Articles: Genetics, Cell Biology & Anatomy
BMP-7/OP-1, a member of the transforming growth factor-beta (TGF-beta) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions responsible for establishing both organs appear largely unaffected. However, the absence of BMP-7 disrupts the subsequent cellular interactions required for their continued growth and development. Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential …
The Nascent-Polypeptide-Associated Complex: Having A "Nac" For Fidelity In Translocation., William Wickner
The Nascent-Polypeptide-Associated Complex: Having A "Nac" For Fidelity In Translocation., William Wickner
Dartmouth Scholarship
No abstract provided.
Role Of 4-1bb Ligand In Costimulation Of T Lymphocyte Growth And Its Upregulation On M12 B Lymphomas By Camp, M. A. Debenedette, N. R. Chu, K. E. Pollok, J. Hurtado, William F. Wade, Byoung S. Kwon, Tania H. Watts
Role Of 4-1bb Ligand In Costimulation Of T Lymphocyte Growth And Its Upregulation On M12 B Lymphomas By Camp, M. A. Debenedette, N. R. Chu, K. E. Pollok, J. Hurtado, William F. Wade, Byoung S. Kwon, Tania H. Watts
Dartmouth Scholarship
K46J B lymphomas express a T cell costimulatory activity that is not inhibited by CTLA-4Ig, anti-B7-1, anti-B7-2, anti-intercellular adhesion molecule 1 or antibodies to heat stable antigen. In this paper we report that this costimulatory activity is mediated at least in part by 4-1BB ligand, a member of the tumor necrosis factor (TNF) gene family that binds to 4-1BB, a T cell activation antigen with homology to the TNF/nerve growth factor receptor family. A fusion protein between 4-1BB and alkaline phosphatase (4-1BB-AP) blocks T cell activation by K46J lymphomas in both an antigen-specific system and with polyclonally (anti-CD3) activated T …