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Full-Text Articles in Medicine and Health Sciences
Predator-Based Fear Conditioning: A Novel Approach To The Study Of The Neurobiology Of Memory, Joshua D. Halonen
Predator-Based Fear Conditioning: A Novel Approach To The Study Of The Neurobiology Of Memory, Joshua D. Halonen
USF Tampa Graduate Theses and Dissertations
This series of experiments developed novel paradigms involving the integration of conventional and ethologically relevant forms of reinforcement in the study of fear conditioning in rats. Experiment 1 compared the effects of foot shock, immobilization and predator exposure, alone and in combination, on the expression of conditioned fear memory and extinction. The combination of all 3 reinforcers produced a significantly stronger fear memory and greater resistance to extinction, compared to when each reinforcer was administered alone. Furthermore, whereas conditioning with foot shock, alone, resulted in rapid extinction of the fear memory, the combination of immobilization and cat exposure, or all …
Efficacy Of Increased Ube3a Protein Levels In The Brain In Rescuing The Phenotype Of An Angelman Syndrome Mouse, Jennifer L. Daily
Efficacy Of Increased Ube3a Protein Levels In The Brain In Rescuing The Phenotype Of An Angelman Syndrome Mouse, Jennifer L. Daily
USF Tampa Graduate Theses and Dissertations
Angelman syndrome (AS), a genetic disorder occurring in approximately one in every 15,000 births, is characterized by severe mental retardation, seizures, difficulty speaking and ataxia. The gene responsible for AS was discovered to be UBE3A and encodes an E6-AP ubiquitin ligase. A unique feature of this gene is that it undergoes maternal imprinting in a neuron-specific manner. In the majority of AS cases, there is a mutation or deletion in the maternally inherited UBE3A gene, although other cases are the result of uniparental disomy or mismethylation of the maternal gene. While most human disorders characterized by severe mental retardation involve …