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Full-Text Articles in Medicine and Health Sciences
Investigation Of Spatio-Temporal Effects Of Fmri Visual Field Mapping Techniques On V1, John J. Janik
Investigation Of Spatio-Temporal Effects Of Fmri Visual Field Mapping Techniques On V1, John J. Janik
Dissertations (1934 -)
Blood oxygenation level dependent functional magnetic resonance imaging has been used extensively for mapping the representation of the visual field within the human brain. Visual field mapping using fMRI has been used clinically to assess patients with cortical pathology and to plan surgical treatment impacting the visual system. The accuracy of fMRI-based visual field mapping methods needs to be better understood for clinical use. This accuracy can be important for presurgical mapping of brain function near a tumor resection site since inaccurate rendition of the underlying neural function could lead to inappropriate resection of viable brain tissue. The most widely …
Human Cytosolic Sulfotransferase 2b1b: Structure, Function And Expression In Human Brain, Emily D. Salman
Human Cytosolic Sulfotransferase 2b1b: Structure, Function And Expression In Human Brain, Emily D. Salman
All ETDs from UAB
The human cytosolic sulfotransferases are a family of phase II drug-metabolizing enzymes that conjugate a sulfonate moiety from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to a hydroxyl moeity on a substrate. SULT2B1b catalyzes the sulfation of hydroxysteroids as well as many xenobiotics; and is expressed extra-hepatically. SULT2B1b is a unique SULT because it has amino (N)- and carboxy (C)-terminal peptide extensions, undergoes post-translational modification, and is localized in both the cytosol and nucleus. Analysis of SULT2B1b revealed that the N- and C-terminal extensions of SULT2B1b are predicted to be intrinsically unstructured peptides. Size exclusion chromatography has revealed that SULT2B1b is enzymatically active as …
Intracellular Distribution Of Glycogen Synthase Kinase-3beta In The Brain, Johanna C. Gandy
Intracellular Distribution Of Glycogen Synthase Kinase-3beta In The Brain, Johanna C. Gandy
All ETDs from UAB
The widely distributed serine/threonine kinase glycogen synthase kinase 3beta is well known for its multiple functions in the health brain tissue, which include cell fate, neuronal growth and remodeling, synaptic plasticity, and neuroinflammation. However much of GSK3beta focuses on its abnormal functions in neurological disorders like Alzheimer's Disease and psychiatric disorders. To maintain normal GSK3beta function in the brain, this constitutively active kinase must be strictly regulated. Many factors within the cell work together to influence GSK3beta activity. Two ways to regulate GSK3beta activity are through phosphorylation by upstream kinases or the formation of protein complexes that block substrate binding. …