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Full-Text Articles in Medicine and Health Sciences
Effects Of Thymoquinone And Memantine Alone And In Combination On Memory And Hippocampal Morphology In Rats With Streptozotocin-Induced Alzheimer's Disease, Şeyma Özsoy, Zi̇ya Çakir, Eli̇f Akçay, Fi̇kret Gevrek
Effects Of Thymoquinone And Memantine Alone And In Combination On Memory And Hippocampal Morphology In Rats With Streptozotocin-Induced Alzheimer's Disease, Şeyma Özsoy, Zi̇ya Çakir, Eli̇f Akçay, Fi̇kret Gevrek
Turkish Journal of Medical Sciences
Background/aim: Alzheimer's disease (AD) is a progressive neurodegenerative disease. Thymoquinone (TQ) has broad biological functions, including antiinflammatory, antioxidant, neuroprotective properties. Memantine (MEM) is indicated for the symptomatic treatment of moderate to severe AD. We aimed to evaluate the effect of TQ alone or in combination with MEM on memory and hippocampal morphology in an STZ-induced rat AD model. Materials and methods: Thirty male rats were included in this study. The AD model was created by giving ICV STZ. The rats were divided into 5 groups (n = 6 each). Group 1 (control group): The rats received only ICV-STZ 3 mg/kg …
The Effect Of Ghrelin On Antioxidant Status In The Rat’S Model Of Alzheimer's Disease Induced By Amyloid-Beta, Fatemeh Sarlaki, Zahra Shahsavari, Fatemeh Goshadrou, Faezeh Naseri, Mohammad Keimasi, Majid Sirati-Sabet Dr
The Effect Of Ghrelin On Antioxidant Status In The Rat’S Model Of Alzheimer's Disease Induced By Amyloid-Beta, Fatemeh Sarlaki, Zahra Shahsavari, Fatemeh Goshadrou, Faezeh Naseri, Mohammad Keimasi, Majid Sirati-Sabet Dr
BioMedicine
Alzheimer's disease (AD) is a neurodegenerative disorder associated with amyloid-beta (Aβ) plaque formation and oxidative stress in the brain. Ghrelin has been proven to exert antioxidant activity and neuroprotection in different neurological diseases. This study is going on to examine the effect of ghrelin on antioxidant status in the rat’s model of AD induced by Aβ. Cognitive impairment was induced by intra-hippocampal administration of Aβ (10 µg) in Wistar rats and ghrelin (80 μg/kg) was administrated intraperitoneal for ten consecutive days. Behavior was assessed with Morris water maze and passive avoidance tests. Malondialdehyde (MDA) level as a marker of lipid …
Ultrasonographic/Regional Muscle Measurements For Diagnosing Sarcopenia In Older Adults With And Without Dementia, Zekeri̇ya Ülger, Gözde Şengül Ayçi̇çek, Özgür Kara, Murat Kara
Ultrasonographic/Regional Muscle Measurements For Diagnosing Sarcopenia In Older Adults With And Without Dementia, Zekeri̇ya Ülger, Gözde Şengül Ayçi̇çek, Özgür Kara, Murat Kara
Turkish Journal of Medical Sciences
Background/aim: Sarcopenia and dementia are growing concerns among older adults that muscle and brain atrophy may cooccur. We aimed to compare the age-related loss of muscle mass by using ultrasound (US), and skeletal muscle mass index (SMI) by bioelectrical impedance analysis in older adults with and without dementia. Materials and methods: A total of 221 older adults aged ≥65 years were included in the study. The diagnosis of sarcopenia was established if low muscle mass according to either SMI or sonographic gastrocnemius (GC) muscle thickness was combined with low grip strength. The diagnosis of dementia was based on the National …
Microbial Influence On Alzheimer's Disease, Ashley N. Hamby
Microbial Influence On Alzheimer's Disease, Ashley N. Hamby
The Cardinal Edge
No abstract provided.
Effects Of Tacrolimus On C-Fos In Hippocampus And Memory Performances Instreptozotocin Model Of Alzheimer's Disease Of Rats, Ayşe Köylü, Berri̇n Zühal Altunkaynak, Burcu Deli̇baş
Effects Of Tacrolimus On C-Fos In Hippocampus And Memory Performances Instreptozotocin Model Of Alzheimer's Disease Of Rats, Ayşe Köylü, Berri̇n Zühal Altunkaynak, Burcu Deli̇baş
Turkish Journal of Medical Sciences
Background/aim: Calcineurin, an inhibitor of calcium dependent phosphatase is highly presented in a brain of an Alzheimer?s disease. Aging brain gets more sensitive to hyperactivation of calcineurin, and this event causes tau neurofibrillary plaque accumulation, which is one of the outcomes of this disease. The regions of hippocampus are much effected from the results of this process. Our hypothesis is that a calcineurin inhibitor, tacrolimus, could prevent the accumulation and the decrease of the neuronal cells. Therefore, this immunosuppressive drug could be a candidate for an early treatment of Alzheimer disease. Materials and methods: Fifteen male Wistar albino rats were …
Nutraceutical Potential For Alzheimer's Disease Treatment, Alex Gewecke
Nutraceutical Potential For Alzheimer's Disease Treatment, Alex Gewecke
Undergraduate Research Journal
Alzheimer’s disease (AD) is a progressive disorder involving buildup of excessive amounts of proteins such as beta amyloid in the brain that leads to memory loss, inability to perform daily functions, and an early death. By 2060, the number of cases is forecast to nearly triple current numbers. Age is the primary risk factor for AD and no new drugs have been approved since 2003. Nutraceuticals, a broad category of substances that can be utilized for both medicinal and nutritional purposes may be able to help, which is why they are being more widely researched. Overall, a number of attempts …
Effects Of The Online Computerized Cognitive Training Program Beynex On The Cognitive Tests Of Individuals With Subjective Cognitive Impairment And Alzheimer's Disease On Rivastigmine Therapy, Ni̇lgün Çinar, Türker Ahmet Hasan Şahi̇ner
Effects Of The Online Computerized Cognitive Training Program Beynex On The Cognitive Tests Of Individuals With Subjective Cognitive Impairment And Alzheimer's Disease On Rivastigmine Therapy, Ni̇lgün Çinar, Türker Ahmet Hasan Şahi̇ner
Turkish Journal of Medical Sciences
Background/aim: Clinical trials conducted on the efficacy of computerized cognitive training (CCT) programs have not led to any important breakthroughs. CCT is a safe and inexpensive approach, but its efficacy in patients on rivastigmine therapy has not been evaluated. This study aims to compare effects of CCT and examines rivastigmine to determine whether CCT has any further contributions to make. Materials and methods: Sixty individuals with subjective memory complaint (SCI) and 60 individuals with early stage Alzheimer's dementia (AD) were subjected to the Montreal Cognitive Assessment (MoCA), Cambridge Cognition (CANTAB tests: MOT, PRM, DMS, SWM, PAL, RTI), and Bayer-ADL. After …
Potential Role Of Some Nutraceuticals In The Regression Of Alzheimer’S Disease In An Experimental Animal Model, Hanaa Hamdy Ahmed, Wafaa Ghoneim Shousha, Rehab Mahmoud Hussien, Abdel Razik Hussein Farrag
Potential Role Of Some Nutraceuticals In The Regression Of Alzheimer’S Disease In An Experimental Animal Model, Hanaa Hamdy Ahmed, Wafaa Ghoneim Shousha, Rehab Mahmoud Hussien, Abdel Razik Hussein Farrag
Turkish Journal of Medical Sciences
The goal of this study was to evaluate the potential role of some nutraceuticals, coenzyme Q_{10}, vitamin B complex, and lecithin against aluminum-induced neurodegeneration characteristic of Alzheimer's disease. Materials and methods: Ninety-six male and female Sprague Dawley rats were divided into 2 main groups, namely female and male. Each group was divided into 6 subgroups. Group 1 served as control group. Group 2 was administered AlCl_3 for 4 months. Groups 3, 4, 5, and 6 were administered with AlCl_3 for 4 months then treated with Coenzyme Q_{10}, vitamin B complex, lecithin, or all in combination for 3 months, respectively. Brain …
Atypical Clinical Manifestation Of Dementia: A Progressive Visuospatial Deficit, Mehmet Güney Şenol, Hakan Tekeli̇, Erdem Toğrol, Mehmet Saraçoğlu
Atypical Clinical Manifestation Of Dementia: A Progressive Visuospatial Deficit, Mehmet Güney Şenol, Hakan Tekeli̇, Erdem Toğrol, Mehmet Saraçoğlu
Turkish Journal of Medical Sciences
Clinically and neuropathologically dementia is a very heterogeneous disease. Alzheimer's disease (Alzheimer disease, AD), the most common cause of dementia, is an acquired cognitive and behavioral impairment of sufficient severity that markedly interferes with social and occupational functioning. This disease may be manifested as progressive memory problems, visuospatial deterioration, aphasia and/or deficits of executive functions. The patient we report here is a 73-year-old female patient with loss of ability of finding directions and understanding the shapes of materials. Her complaints increased progressively during the last two years. Even if she had retired from tailoring, she had deterioration in the visuospatial …
Antioxidant Status, Lipid Peroxidation Products And Cystatin C As Potential Clinical Markers Of Alzheimer's Disease In Systemic Circulation, Ayşegül Akbay Yarpuzlu, Çi̇ğdem Aydemi̇r, Selda Demi̇rtaş, Engi̇n Turan Tuncer, Orhan Canpolat, Yasemi̇n Genç
Antioxidant Status, Lipid Peroxidation Products And Cystatin C As Potential Clinical Markers Of Alzheimer's Disease In Systemic Circulation, Ayşegül Akbay Yarpuzlu, Çi̇ğdem Aydemi̇r, Selda Demi̇rtaş, Engi̇n Turan Tuncer, Orhan Canpolat, Yasemi̇n Genç
Turkish Journal of Medical Sciences
Growing data suggest oxidative stress contributes to the pathogenesis of Alzheimer's disease (AD). The objective of this study was to assess the value of antioxidant potential (AOP), antioxidant status (AOS) and thiobarbituric acid reactive substances (TBARS) and the cysteine protease inhibitor Cystatin C that plays a role in the processing of amyloid _ as clinical markers of AD in peripheral circulation and to find out the agreement limits of AOP and AOS as clinical laboratory tests. To do this, 21 severely demented patients fitting the DSM-IV diagnostic criteria for Alzheimer's type dementia as well as through minimental state examination were …