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Full-Text Articles in Medicine and Health Sciences
Outcomes Of The Conservative Management Of The Patients With Endometrialintraepithelial Neoplasia/Endometrial Cancer: Wait Or Treat!, Esra İşçi̇ Bostanci, Yasi̇n Durmuş, Si̇nem Ayşe Duru Çöteli̇, Fulya Kayikçioğlu, Nuretti̇n Boran
Outcomes Of The Conservative Management Of The Patients With Endometrialintraepithelial Neoplasia/Endometrial Cancer: Wait Or Treat!, Esra İşçi̇ Bostanci, Yasi̇n Durmuş, Si̇nem Ayşe Duru Çöteli̇, Fulya Kayikçioğlu, Nuretti̇n Boran
Turkish Journal of Medical Sciences
Background/aim: The objective of the study was to evaluate the response, relapse, reproductive results and demographic features of the patients with endometrioid adenocancer (EAC) and endometrial intraepithelial neoplasia (EIN) who were treated with conservative treatment. This is the largest study when we consider the single center studies in this field. Materials and methods: In the current retrospective study, 38 patients (6 EAC, 31 EIN, 1 synchronous tumors of ovary and endometrium) were recruited. They were treated with progesterone products for their fertility desire and comorbidity. Reproductive results, response rates, and recurrence rates were calculated and survival analyses were performed. Results: …
Is Conut Score A Prognostic Index In Patients With Diffuse Large Cell Lymphoma?, Gülsüm Akgün Çağliyan, Si̇bel Hacioğlu, Başak Ünver Koluman, Kadi̇r İlkkiliç, Ruki̇ye Nar, Mehmet Nuri̇ Başer, Asli Bozdemi̇r, Hande Şenol, Ni̇lay Şen Türk, Veysel Erol, Onurcan Yildirim, Ömer Çağliyan, Ni̇l Güler
Is Conut Score A Prognostic Index In Patients With Diffuse Large Cell Lymphoma?, Gülsüm Akgün Çağliyan, Si̇bel Hacioğlu, Başak Ünver Koluman, Kadi̇r İlkkiliç, Ruki̇ye Nar, Mehmet Nuri̇ Başer, Asli Bozdemi̇r, Hande Şenol, Ni̇lay Şen Türk, Veysel Erol, Onurcan Yildirim, Ömer Çağliyan, Ni̇l Güler
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to evaluate the effect of Controlling Nutritional Status (CONUT) score on the prognosis in patients with diffuse large B-cell lymphoma (DLBCL). Materials and methods: The present study was a retrospective study. The CONUT score was calculated based on serum albumin, total cholesterol and lymphocyte levels. This study included a total of 266 patients, 131 (49.2%) were female and 135 (50.8%) were male. The median follow-up period was 51 months (range: 1-190). Results: The median age was 64 years. The cut off CONUT was 1.5. There was a significant difference between patients with high …
Extracorporeal Carbon Dioxide Removal (Ecco2r) In Copd And Ards Patients Withsevere Hypercapnic Respiratory Failure. A Retrospective Case-Control Study, Volkan İnal, Serdar Efe
Extracorporeal Carbon Dioxide Removal (Ecco2r) In Copd And Ards Patients Withsevere Hypercapnic Respiratory Failure. A Retrospective Case-Control Study, Volkan İnal, Serdar Efe
Turkish Journal of Medical Sciences
Background/aim: Treatment of severe hypercapnic respiratory failure (HRF) has some challenges in patients with chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS), especially when lung protective ventilation (LPV) strategies are required. Extracorporeal CO2 removal (ECCO2R) therapy is an emerging option to manage hypercapnia while allowing LPV in these cases. However, further data on ECCO2R use is still needed to make clear recommendations. Materials and methods: This study was conducted on patients admitted to intensive care unit (ICU) between January 1st, 2016 to December 31st, 2019. The medical records were retrospectively scanned in institutional software database. Patients who …
What Is The Predictive Value Of Preoperative Ca 125 Level On The Survival Rate Of Type 1endometrial Cancer?, Şafak Yilmaz Baran, Songül Alemdaroğlu, Gülşen Doğan Durdağ, Seda Yüksel Şi̇mşek, Fi̇li̇z Bolat, Fati̇h Köse, Hüsnü Çeli̇k
What Is The Predictive Value Of Preoperative Ca 125 Level On The Survival Rate Of Type 1endometrial Cancer?, Şafak Yilmaz Baran, Songül Alemdaroğlu, Gülşen Doğan Durdağ, Seda Yüksel Şi̇mşek, Fi̇li̇z Bolat, Fati̇h Köse, Hüsnü Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: To investigate the utility of preoperative serum cancer antigen 125 (CA 125) levels in type 1 endometrial carcinoma (EC) as a marker for determining poor prognostic factors and survival. Material and methods: All patients with endometrial cancer, who had been treated between 2012 and 2020, were retrospectively reviewed, and finally, 256 patients with type 1 endometrium carcinoma were included in the study. The relationship between the clinicopathological characteristics, CA 125 level, and survival rates were analyzed. The cut-off value for the preoperative serum CA 125 level was defined as 16 IU/L. Results: The median serum CA 125 levels were …
The Prognostic Value Of Serum Levels Of A Proliferation-Inducing Ligand (April) Intreatment-Naïve Patients With Chronic Lymphocytic Leukemia, Si̇nem Ni̇hal Esatoğlu, Di̇lek Keski̇n, Ahmet Emre Eşkazan, Tuğrul Elverdi̇, Ayşe Sali̇hoğlu, Muhli̇s Cem Ar, Şeni̇z Öngören, Zafer Başlar, Yildiz Aydin, Hafi̇ze Uzun, Teoman Soysal
The Prognostic Value Of Serum Levels Of A Proliferation-Inducing Ligand (April) Intreatment-Naïve Patients With Chronic Lymphocytic Leukemia, Si̇nem Ni̇hal Esatoğlu, Di̇lek Keski̇n, Ahmet Emre Eşkazan, Tuğrul Elverdi̇, Ayşe Sali̇hoğlu, Muhli̇s Cem Ar, Şeni̇z Öngören, Zafer Başlar, Yildiz Aydin, Hafi̇ze Uzun, Teoman Soysal
Turkish Journal of Medical Sciences
Background/aim: A proliferation-inducing ligand (APRIL) has been investigated as a prognostic marker in chronic lymphocytic leukemia (CLL) patients. However, there is no cut-off level for serum APRIL (sAPRIL) levels that predict time to treatment in CLL patients. Materials and methods: Between May and December 2012, 94 consecutive CLL patients and 25 healthy controls were assessed. sAPRIL levels were measured by ELISA. Demographic data and prognostic markers were obtained from the patients' files. Treatment-naïve patients were followed up for 6.5 years for any treatment need. Results: Patients were divided into 3 groups: Treatment-naïve (n = 47), chemotherapy receiving (n = 25), …
Risk Factors For Evisceration In Gynecological Oncology Surgeries, Fati̇h Kiliç, Günsu Ki̇myon Cömert, Mehmet Ünsal, İsmet Çi̇ğdem Kiliç, Caner Çakir, Di̇lek Yüksel, Mustafa Alper Karalök, Osman Türkmen, Ahmet Taner Turan
Risk Factors For Evisceration In Gynecological Oncology Surgeries, Fati̇h Kiliç, Günsu Ki̇myon Cömert, Mehmet Ünsal, İsmet Çi̇ğdem Kiliç, Caner Çakir, Di̇lek Yüksel, Mustafa Alper Karalök, Osman Türkmen, Ahmet Taner Turan
Turkish Journal of Medical Sciences
Background/aim: To investigate the risk factors for evisceration in a gynecological oncology population. The secondary aim was to evaluate the impact of evisceration on survival. Materials and methods: Inclusion criteria consisted of having had an elective surgery performed through a xiphoidopubic incision in our institution and having a gynecological malignancy based on pathology. A total of 198 patients were evaluated, 54 with evisceration and 144 without evisceration. Due to the widely varied prognosis of female genital cancers, the survival was analyzed on a homogenized group, including only 62 patients with primary advanced stage epithelial ovarian-tubal-peritoneal cancer. Results: The preoperative factors …
Efficacy And Safety Of Ruxolitinib In Patients With Myelofibrosis: A Retrospective Andmulticenter Experience In Turkey, Nur Soyer, Ridvan Ali̇, Mehmet Turgut, İbrahi̇m Celaletti̇n Haznedaroğlu, Asu Fergün Yilmaz, İsmet Aydoğdu, Ali̇ Pi̇r, Volkan Karakuş, Gökhan Özgür, Cem Ki̇s, Funda Ceran, Gül İlhan, Melda Özkan, Müzeyyen Aslaner, İdri̇s İnce
Efficacy And Safety Of Ruxolitinib In Patients With Myelofibrosis: A Retrospective Andmulticenter Experience In Turkey, Nur Soyer, Ridvan Ali̇, Mehmet Turgut, İbrahi̇m Celaletti̇n Haznedaroğlu, Asu Fergün Yilmaz, İsmet Aydoğdu, Ali̇ Pi̇r, Volkan Karakuş, Gökhan Özgür, Cem Ki̇s, Funda Ceran, Gül İlhan, Melda Özkan, Müzeyyen Aslaner, İdri̇s İnce
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to assess the efficacy and safety of ruxolitinib in patients with myelofibrosis. Materials and methods: From 15 centers, 176 patients (53.4% male, 46.6% female) were retrospectively evaluated. Results: The median age at ruxolitinib initiation was 62 (28-87) and 100 (56.8%) of all were diagnosed as PMF. Constitutional symptoms were observed in 84.7%. The median initiation dose of ruxolitinib was 30 mg (10-40). Dose change was made in 69 (39.2%) patients. Forty seven (35.6%) and 20 (15.2%) of 132 patients had hematological and nonhematological adverse events, respectively. The mean spleen sizes before and after …
Prognostic Value Of Oxygen Saturation And Heart Rate During A Six-Minute Walk Test Inpediatric Pulmonary Hypertension, Vi̇ldan Atasayan, Fatma Canbeyli̇, Fatma Sedef Tunaoğlu, Ayşe Deni̇z Oğuz, Bülent Çeli̇k, Serdar Kula
Prognostic Value Of Oxygen Saturation And Heart Rate During A Six-Minute Walk Test Inpediatric Pulmonary Hypertension, Vi̇ldan Atasayan, Fatma Canbeyli̇, Fatma Sedef Tunaoğlu, Ayşe Deni̇z Oğuz, Bülent Çeli̇k, Serdar Kula
Turkish Journal of Medical Sciences
Background/aim: To evaluate the pre and post-treatment heart rate and oxygen (O2 ) saturation values measured before, during and after 6MWT in children who received PAH-specific treatment and to determine the effect of these variables on prognosis. Materials and methods: This retrospective study included 29 patients who were diagnosed as PAH and treated. The transcutaneous O2 saturationand heart rate levels were recorded before the test: baseline (Sat0, HR0), at the end of the test: exercise (Sat1, HR1) and 5 min after the test: recovery (Sat2, HR2). The increase in heart rate was defined as HR1-HR0 and the decrease in saturation …