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Full-Text Articles in Medicine and Health Sciences
Contribution Of The Human Microbiome And Proteus Mirabilis To Onset And Progression Of Rheumatoid Arthritis: Potential For Targeted Therapy, Jessica Kerpez, Marc Kesselman, Michelle Demory Beckler
Contribution Of The Human Microbiome And Proteus Mirabilis To Onset And Progression Of Rheumatoid Arthritis: Potential For Targeted Therapy, Jessica Kerpez, Marc Kesselman, Michelle Demory Beckler
Internet Journal of Allied Health Sciences and Practice
The human microbiome has been shown to play a role in the regulation of human health, behavior, and disease. Data suggests that microorganisms that co-evolved within humans have an enhanced ability to prevent the development of a large spectrum of immune-related disorders but may also lead to the onset of conditions when homeostasis is disrupted. In many conditions, a link between dysbiosis (microbial imbalance or microbiome upset) has been identified and associated with immune conditions such as rheumatoid arthritis (RA). This review provides insight into how an individual’s unique microbiome, combined with a genetic predisposition and environmental factors may lead …
Dental And Temporomandibular Joint Alterations In Rheumatoid Arthritis Patients Andtheir Association With Salivary Oxidative Stress, Deni̇z Yaman, Duygu Göller Bulut, Gülbahar Ustaoğlu, Emre Avci, Murat Taşçi
Dental And Temporomandibular Joint Alterations In Rheumatoid Arthritis Patients Andtheir Association With Salivary Oxidative Stress, Deni̇z Yaman, Duygu Göller Bulut, Gülbahar Ustaoğlu, Emre Avci, Murat Taşçi
Turkish Journal of Medical Sciences
Background/aim: Rheumatoid arthritis (RA) is the most extensive inflammatory arthritis causing permanent deformities in the joint. Increasing evidence suggests that oxidative stress is a substantial factor in the pathogenesis of RA. This study aimed to examine the salivary oxidant-antioxidant status of RA and control groups and to compare these biomarkers by correlating them with disease activity, acute phase reactants, and clinical findings. Materials and methods: Age and sex-matched 60 participants including 30 patients with RA and 30 control (50 females, 10 males; mean age: 42.62 ± 10.89 years) were evaluated. RA disease activity and severity were evaluated by the disease …
The Inhibition Of Src Kinase Suppresses The Production Of Matrix Metalloproteinases Infrom Synovial Fibroblasts And Inhibits Mapk And Stats Pathways, Demet Yalçin Kehri̇bar, Meti̇n Özgen, Servet Yolbaş, Ahmet Yildirim, Neşe Başak Türkmen, Ebru Önalan, Osman Çi̇ftçi̇, İbrahi̇m Hani̇fi̇ Özercan, Süleyman Serdar Koca
The Inhibition Of Src Kinase Suppresses The Production Of Matrix Metalloproteinases Infrom Synovial Fibroblasts And Inhibits Mapk And Stats Pathways, Demet Yalçin Kehri̇bar, Meti̇n Özgen, Servet Yolbaş, Ahmet Yildirim, Neşe Başak Türkmen, Ebru Önalan, Osman Çi̇ftçi̇, İbrahi̇m Hani̇fi̇ Özercan, Süleyman Serdar Koca
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to investigate the antiarthritic potentials of the inhibition of Src kinase in vivo and in vitro settings. Materials and methods: Arthritis was induced by intradermal injection of chicken type II collagen combined with incomplete Freund's adjuvant (collagen induced arthritis [CIA] model) in Wistar albino rats. One day after the onset of arthritis, dasatinib, a potent Src kinase inhibitor, (5 mg/kg/day) was given via oral gavage. Tissue Src, Fyn, MAPK and STAT mRNA expressions were determined by real-time polymerase chain reaction. On the other hand, fibroblast like synoviocytes (FLSs) were harvested patients with rheumatoid …
Efficacy, Retention, And Safety Of Tofacitinib In Real-Life: Hur-Bio Monocentric Experience, Emre Bi̇lgi̇n, Furkan Ceylan, Emi̇ne Duran, Bayram Fari̇soğullari, Ertuğrul Çağri Bölek, Gözde Kübra Yardimci, Levent Kiliç, Ali̇ Akdoğan, Ömer Karadağ, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Umut Kalyoncu
Efficacy, Retention, And Safety Of Tofacitinib In Real-Life: Hur-Bio Monocentric Experience, Emre Bi̇lgi̇n, Furkan Ceylan, Emi̇ne Duran, Bayram Fari̇soğullari, Ertuğrul Çağri Bölek, Gözde Kübra Yardimci, Levent Kiliç, Ali̇ Akdoğan, Ömer Karadağ, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Umut Kalyoncu
Turkish Journal of Medical Sciences
Background/aim: To assess the real-life efficacy, retention rate, and safety data of tofacitinib in rheumatoid arthritis (RA) patients. Materials and methods: We analyzed all patients registered in the HURBİO database who received at least 1 dose of tofacitinib. Patients who received at least one dose were included in retention analysis; patients with at least 1 control visit were included in efficacy and safety analysis. Factors predicting good response at the last follow-up visit were analyzed by logistic regression analysis. Drug retention rates were calculated using the Kaplan-Meier method and predictors of drug retention were determined by Cox proportional hazard model. …
Preferences Of Inflammatory Arthritis Patients For Biological Disease-Modifyingantirheumatic Drugs In The First 100 Days Of The Covid-19 Pandemic, Umut Kalyoncu, Yavuz Pehli̇van, Servet Akar, Ti̇muçi̇n Kaşi̇foğlu, Gezmi̇ş Ki̇myon, Ömer Karadağ, Hüseyi̇n Edi̇z Dalkiliç, Ali̇ İhsan Ertenli̇, Levent Kiliç, Emi̇ne Duygu Ersözlü, Cemal Bes, Hakan Emmungi̇l, Ridvan Mercan, Eli̇f Edi̇boğlu, Ni̇lüfer Alpay Kanitez
Preferences Of Inflammatory Arthritis Patients For Biological Disease-Modifyingantirheumatic Drugs In The First 100 Days Of The Covid-19 Pandemic, Umut Kalyoncu, Yavuz Pehli̇van, Servet Akar, Ti̇muçi̇n Kaşi̇foğlu, Gezmi̇ş Ki̇myon, Ömer Karadağ, Hüseyi̇n Edi̇z Dalkiliç, Ali̇ İhsan Ertenli̇, Levent Kiliç, Emi̇ne Duygu Ersözlü, Cemal Bes, Hakan Emmungi̇l, Ridvan Mercan, Eli̇f Edi̇boğlu, Ni̇lüfer Alpay Kanitez
Turkish Journal of Medical Sciences
Background/aim: To evaluate treatment adherence and predictors of drug discontinuation among patients with inflammatory arthritis receiving bDMARDs within the first 100 days after the announcement of the COVID-19 pandemic. Materials and methods: A total of 1871 patients recorded in TReasure registry for whom advanced therapy was prescribed for rheumatoid arthritis (RA) or spondyloarthritis (SpA) within the 3 months (6-9 months for rituximab) before the declaration of COVID-19 pandemic were evaluated, and 1394 (74.5%) responded to the phone survey. Patients' data regarding demographic, clinical characteristics and disease activity before the pandemic were recorded. The patients were inquired about the diagnosis of …
Effects Of The Covid-19 Pandemic On Psychology And Disease Activity In Patients Withankylosing Spondylitis And Rheumatoid Arthritis, Şaki̇r Gica, Yasemi̇n Akkubak, Zaki̇re Kübra Aksoy, Adem Küçük, Erkan Cüre
Effects Of The Covid-19 Pandemic On Psychology And Disease Activity In Patients Withankylosing Spondylitis And Rheumatoid Arthritis, Şaki̇r Gica, Yasemi̇n Akkubak, Zaki̇re Kübra Aksoy, Adem Küçük, Erkan Cüre
Turkish Journal of Medical Sciences
Background/aim: The COVID-19 outbreak is known to increase stress levels of most patients with chronic diseases. Patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are highly susceptible to environmental stress. In the current study, we aimed to determine how the COVID-19 pandemic psychologically affected patients with chronic progressive diseases such as AS and RA and the effects of these psychological factors on disease activity. Materials and methods: Age and sex-matched patients with AS (n = 80), RA (n = 80), and healthy controls (n = 80) were included in the study. All participants were evaluated with the "Perceived COVID-19 …