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Examining Neuroanatomical Effects Of Prenatal Valproic Acid And Postnatal Testosterone In A Mouse Model Of Autism Spectrum Disorder, Bishakha Kumari, Elizabeth Ann Gordon, Cynthia Corbitt
Examining Neuroanatomical Effects Of Prenatal Valproic Acid And Postnatal Testosterone In A Mouse Model Of Autism Spectrum Disorder, Bishakha Kumari, Elizabeth Ann Gordon, Cynthia Corbitt
Undergraduate Arts and Research Showcase
Sex differences in Autism Spectrum Disorder (ASD) are well documented; males are diagnosed 4:1 over females. Testosterone (T) is one factor that differs by sex in humans and mice that could increase vulnerability to developing ASD in males. Valproic acid (VPA) is an anticonvulsant that has been found to increase the risk of autism in male offspring of pregnant women who take it to control seizures and is commonly used in mouse models of ASD. After prenatal VPA or vehicle on embryonic day 13, testosterone (T) or vehicle was administered to the mice on postnatal day 2 to investigate whether …