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Full-Text Articles in Medicine and Health Sciences
Non-Invasive Mitochondrial Modulation With Near-Infrared Light Reduces Brain Injury After Stroke, Christos Dionisos Strubakos
Non-Invasive Mitochondrial Modulation With Near-Infrared Light Reduces Brain Injury After Stroke, Christos Dionisos Strubakos
Wayne State University Dissertations
Acute ischemic stroke is a debilitating disease that causes significant brain injury.
While rapid restoration of blood flow is critical to salvage the ischemic brain, reperfusion
of tissue can further drive brain damage by inducing generation of mitochondrial reactive
oxygen species (Chouchani et al., 2014a). Recent studies by our group found that noninvasive
mitochondrial modulation (NIMM) with near-infrared (NIR) light can limit the
production of reactive oxygen species following global brain ischemia (T. H. Sanderson
et al., 2018). NIR interacts with the rate limiting step of the mitochondrial electron
transport chain (ETC), cytochrome c oxidase (COX), and modulates mitochondrial
respiration. …
Change In Processing Speed And Its Associations With Cerebral White Matter Microstructure, Muzamil Arshad
Change In Processing Speed And Its Associations With Cerebral White Matter Microstructure, Muzamil Arshad
Wayne State University Dissertations
The decline of cognition with age is one of the most feared aspects of aging, while the slowing of responses, or reduced processing speed, is one of the most reliable aspects of aging. Slowing of processing has been hypothesized to affect other domains of cognition as well. Despite the well-known slowing-age relationship and central position processing speed plays in theories of cognitive aging the neurobiological mechanisms which underpin slowing is unclear. If we could identify the biology associated with processing speed we could then attempt to develop interventions to mitigate the effects of age on those variables. In turn we …
Predicting Vision Loss In Healthy Aging With Manganese-Enhanced Mri Of The Rat Eye, David Bissig
Predicting Vision Loss In Healthy Aging With Manganese-Enhanced Mri Of The Rat Eye, David Bissig
Wayne State University Dissertations
In healthy aging, visual function declines throughout adulthood. Age-related changes in neuronal ion homeostasis -- specifically, increased Ca2+ influx through L-type voltage gated calcium channels (L-VGCCs) -- are believed to contribute to certain functional declines, but this possibility has not yet been tested in the neural retina. In young, mid- and old adult Long-Evans rats, we compared visual function (optokinetic tracking), as well as retinal physiology and eye morphology (Mn2+-enhanced MRI (MEMRI), which uses neuronal Mn2+ uptake as a marker of Ca2+ influx). We documented significant age-related decreases in visual performance and increases in retinal ion influx. We confirmed that …