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Full-Text Articles in Medicine and Health Sciences
Alternations Of Nmda And Gabab Receptor Function In Development: A Potential Animal Model Of Schizophrenia, Monica Bolton
Alternations Of Nmda And Gabab Receptor Function In Development: A Potential Animal Model Of Schizophrenia, Monica Bolton
UNLV Theses, Dissertations, Professional Papers, and Capstones
Schizophrenia is a debilitating mental disorder that affects up to 3% of the world population. The behavioral symptoms are categorized into positive and negative symptoms, which appear during late adolescence/early adulthood. Unfortunately, the underlying cellular and molecular mechanisms of the disease are poorly understood. Several hypotheses exist to explain mechanisms contributing to these behavioral alterations. One model proposes that a reduced function of the NMDA glutamate receptor on specific GABAergic interneurons may be responsible for deficits in schizophrenia. Post-mortem investigations provide evidence of reductions in both glutamate and GABA-related proteins in patients with schizophrenia. Further, GABAergic interneurons that are activated …
An Investigation Of The Role Of Gabab Ligands On Cued And Contextual Fear Conditioning, Chelcie F. Heaney
An Investigation Of The Role Of Gabab Ligands On Cued And Contextual Fear Conditioning, Chelcie F. Heaney
UNLV Theses, Dissertations, Professional Papers, and Capstones
GABA is the primary inhibitory neurotransmitter in the brain and mediates several processes, including learning and memory. Activating or inhibiting GABA receptors allows for the examination of the effects of altered GABAergic signaling on these processes. The two main receptors, GABAA and GABAB, each have a different mechanism of action when activated, thus they may contribute differentially to learning and memory. The metabotropic GABAB receptor responds with the activation of several intracellular signaling cascades, which provide long-lasting inhibitory effects that primarily mediate network function. Conversely, the GABAA receptor is an ion channel that contributes more immediate inhibitory effects through the …