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Full-Text Articles in Medicine and Health Sciences
Genetic Dissection Of Behavioral And Neurogenomic Responses To Acute Ethanol, Aaron Wolen
Genetic Dissection Of Behavioral And Neurogenomic Responses To Acute Ethanol, Aaron Wolen
Theses and Dissertations
Individual differences in initial sensitivity to ethanol are strongly related to the heritable risk of alcoholism in humans. To elucidate key molecular networks that modulate ethanol sensitivity we performed a systems genetics analysis of ethanol-responsive gene expression in brain regions of the mesocorticolimbic reward circuit (prefrontal cortex, nucleus accumbens and ventral midbrain) across the BXD RI panel, a highly diverse family of isogenic mouse strains before and after treatment with ethanol. Acute ethanol altered the expression of ~2,750 genes in one or more regions and 400 transcripts were jointly modulated in all three. Ethanol-responsive gene networks were extracted with a …
Titrating And Evaluating Multiple Drug Regimens Within Subjects, Margaret Shih
Titrating And Evaluating Multiple Drug Regimens Within Subjects, Margaret Shih
Theses and Dissertations
The dosing of combination therapies is commonly undertaken empirically by practicing physicians, and there is a lack of a coherent algorithm to approach the problem of combination dosing. Current methods of evaluating multiple drug combinations in clinical trials generally do not provide information regarding the location of more effective dosages when the combination is not found to differ from the standard, even though the absence of a difference does not necessarily mean the new combination is ineffective. Additionally, if a new combination is found to be more effective, often a large proportion of the subjects has not benefited from the …