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Brain-Derived Neurotrophic Factor (Bdnf) Signaling Mechanisms That Regulate Learning And Memory In Rats, Clementine Faye Harvey
Brain-Derived Neurotrophic Factor (Bdnf) Signaling Mechanisms That Regulate Learning And Memory In Rats, Clementine Faye Harvey
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Brain-derived neurotrophic factor (BDNF) is a widespread neurotrophin implicated in cellular processes underlying memory, socialization, and emotion; however, little is known about how genetic modification of BDNF interacts with BDNF modulators (e.g., hormones) to regulate BDNF-TrkB signaling. BDNF binds to the TrkB receptor and triggers signaling cascades underlying neuroplasticity, learning, and memory. Inhibitory phosphorylation of one downstream target of the BDNF cascade - GSK3β – is also linked to memory improvements. The Val66Met allele – a single nucleotide polymorphism (SNP) in the Bdnf gene - produces impairments in regulated BDNF release from the cell, as well as deficits in spatial …