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Full-Text Articles in Medicine and Health Sciences
Methods For Increasing Leptin Levels Using Nicotinic Acid Compounds, Elaine L. Jacobson, Myron Jacobson, Hyuntae Kim
Methods For Increasing Leptin Levels Using Nicotinic Acid Compounds, Elaine L. Jacobson, Myron Jacobson, Hyuntae Kim
Graduate Center for Nutritional Sciences Faculty Patents
The invention relates to the use of nicotinic acid and nicotinic acid esters, such as nicotinic acid alkyl esters, to increase the amount of leptin in a subject. As a result, one can treat conditions, such as conditions characterized by wounds, by administering sufficient amounts of nicotinic acid or nicotinic acid ester to increase leptin levels to alleviating amounts. Various conditions and modes of treatment are disclosed.
Method For Identifying Regulators Of Protein-Advanced Glycation End Product (Protein-Age) Formation, Elaine L. Jacobson, Myron Jacobson, Georg T. Wondrak
Method For Identifying Regulators Of Protein-Advanced Glycation End Product (Protein-Age) Formation, Elaine L. Jacobson, Myron Jacobson, Georg T. Wondrak
Graduate Center for Nutritional Sciences Faculty Patents
The invention relates to methods for identifying compounds which affect cellular stress. In particular, the method relates to identifying compounds which inhibit protein advanced glycation end product formation, where the compounds are carbonyl scavengers which inhibit the formation. The assay involves combing the substance of interest with histone H1 and ADP-ribose, and then measuring fluorescence and protein cross linking. Various inhibitors of protein AGE glycation have been identified, using this assay.
Topical Formulations For The Transdermal Delivery Of Niacin And Methods Of Treating Hyperlipidemia, Elaine L. Jacobson, Myron Jacobson, Hyuntae Kim, Moonsun Kim, Jaber G. Qasem
Topical Formulations For The Transdermal Delivery Of Niacin And Methods Of Treating Hyperlipidemia, Elaine L. Jacobson, Myron Jacobson, Hyuntae Kim, Moonsun Kim, Jaber G. Qasem
Graduate Center for Nutritional Sciences Faculty Patents
Niacin and niacin prodrugs are topically administered as suitable formulations to device for impoving the lipid profiles of subjects, preferably humans.