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Longitudinal Extension Of Primary Afferents Is Regulated By Spingosine 1-Phosphate Receptors And Tyrosine Kinase Receptor B In The Embryonic Spinal Cord Via A Brain Derived Neurotrophic Factor Related Mechanism, Michelle Mcnamara
Graduate College Dissertations and Theses
Primary sensory afferent outgrowth within the developing longitudinal pathway of the spinal cord is important for intrasegmental and intersegmental communication that underlies coordination and development of reflexes and contributes to sensory perception. The endogenous mechanisms that regulate primary sensory afferent extension are the primary focus of this dissertation.
This dissertation tested the hypothesis that primary sensory afferent extension in the longitudinal pathway is regulated by sphingosine 1-phosphate type 1 receptor (S1P1R) and tyrosine kinase receptor B (TrkB) through a brain derived neurotrophic factor (BDNF) related mechanism. To test this hypothesis we used embryonic day five (E5) chicken embryos, as this …